Heterozygous diploid and interspecies SCRaMbLEing

Heterozygous diploid and interspecies SCRaMbLEing

SCRaMbLE has been used to rearrange synthetic chromosomes that have been introduced into host yeast. Here the authors produce semi-synthetic heterozygous diploid strains for rapid selection of phenotypes and map the rearrangements underlying selected phenotypes such as thermoresistance and caffeine...

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Bibliographic Details
Main Authors: Michael J. Shen, Yi Wu, Kun Yang, Yunxiang Li, Hui Xu, Haoran Zhang, Bing-Zhi Li, Xia Li, Wen-Hai Xiao, Xiao Zhou, Leslie A. Mitchell, Joel S. Bader, Yingjin Yuan, Jef D. Boeke
Format: Article
Language:English
Published: Nature Portfolio 2018-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-04157-0

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