Eicosapentaenoic acid (EPA)-induced inhibitory effects on porcine coronary and cerebral arteries involve inhibition of prostanoid TP receptors

Eicosapentaenoic acid (EPA)-induced inhibitory effects on porcine coronary and cerebral arteries involve inhibition of prostanoid TP receptors

Abstract This study was performed to elucidate whether eicosapentaenoic acid (EPA) suppresses spasm-prone blood vessel contractions induced by a thromboxane mimetic (U46619) and prostaglandin F2α (PGF2α) and determine whether the primary target of EPA is the prostanoid TP receptor. Accordingly, we a...

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Main Authors: Kento Yoshioka, Keisuke Obara, Shunya Oikawa, Kohei Uemura, Akina Yamaguchi, Kazuki Fujisawa, Hitomi Hanazawa, Miki Fujiwara, Taison Endoh, Taichi Suzuki, Montserrat De Dios Regadera, Daichi Ito, Noboru Saitoh, Yutaka Nakagome, Toma Yamashita, Mayu Kiguchi, Yuka Saito, Yuri Nakao, Hinako Miyaji, Guanghan Ou, Keyue Xu, Yoshio Tanaka
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-16917-6

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