A Pilot Study to Explore a Correlation between Inflammatory Markers and the Wound Healing Rate in Diabetic Patients
<i>Background and objectives</i>: We examined whether there is a significant correlation between inflammatory markers and the wound healing rate (WHR) in diabetic patients. <i>Materials and Methods</i>: A total of 60 patients were divided into two groups depending on the comp...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-03-01
|
| Series: | Medicina |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1648-9144/58/3/390 |
| _version_ | 1797445245509566464 |
|---|---|
| author | Yukwan Song Yongkyu Jo Jeongeun Sohn Robert Kim |
| author_facet | Yukwan Song Yongkyu Jo Jeongeun Sohn Robert Kim |
| author_sort | Yukwan Song |
| collection | DOAJ |
| description | <i>Background and objectives</i>: We examined whether there is a significant correlation between inflammatory markers and the wound healing rate (WHR) in diabetic patients. <i>Materials and Methods</i>: A total of 60 patients were divided into two groups depending on the completion of wound healing (WH) at 5 weeks: the early WH group (period of WH < 5 weeks; <i>n</i> = 27) and the late WH group (period of WH > 5 weeks; <i>n</i> = 33). The baseline characteristics and wound measurements were compared between the two groups. To identify the correlation between inflammatory markers (e.g., white blood cell counts (WBCs), serum C-reactive protein (CRP) levels and erythrocyte sedimentation rate (ESR)) and WHR, we performed a Pearson correlation analysis. <i>Results</i>: The WHR was 8.06 ± 4.02 mm<sup>2</sup>/day in the early WH group and 2.71 ± 0.88 mm<sup>2</sup>/day in the late group. This difference reached statistical significance (<i>p</i> < 0.001). Moreover, WBC counts were significantly higher and serum levels of CRP and ESR were significantly lower in the early WH group than in the late group (<i>p</i> = 0.027, 0.036 and 0.043, respectively). <i>Conclusions</i>: Our results indicate that WBC as well as serum CRP and ESR levels have a significant correlation with WHR in diabetic patients. |
| first_indexed | 2024-03-09T13:23:59Z |
| format | Article |
| id | doaj.art-1085e07237e34adc8286a7388f2cbfc8 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-09T13:23:59Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-1085e07237e34adc8286a7388f2cbfc82023-11-30T21:26:18ZengMDPI AGMedicina1010-660X1648-91442022-03-0158339010.3390/medicina58030390A Pilot Study to Explore a Correlation between Inflammatory Markers and the Wound Healing Rate in Diabetic PatientsYukwan Song0Yongkyu Jo1Jeongeun Sohn2Robert Kim3Department of Plastic and Reconstructive Surgery, Soonsoo Hospital, Hwaseong-si 18617, Gyeonggi, KoreaDepartment of Anesthesiology and Pain Medicine, Cheju Halla General Hospital, Jeju 63127, KoreaDepartment of Anesthesiology and Pain Medicine, Cheju Halla General Hospital, Jeju 63127, KoreaDepartment of Medical and Pharmaceutical Affairs, Doctor CONSULT, Seoul 06296, Korea<i>Background and objectives</i>: We examined whether there is a significant correlation between inflammatory markers and the wound healing rate (WHR) in diabetic patients. <i>Materials and Methods</i>: A total of 60 patients were divided into two groups depending on the completion of wound healing (WH) at 5 weeks: the early WH group (period of WH < 5 weeks; <i>n</i> = 27) and the late WH group (period of WH > 5 weeks; <i>n</i> = 33). The baseline characteristics and wound measurements were compared between the two groups. To identify the correlation between inflammatory markers (e.g., white blood cell counts (WBCs), serum C-reactive protein (CRP) levels and erythrocyte sedimentation rate (ESR)) and WHR, we performed a Pearson correlation analysis. <i>Results</i>: The WHR was 8.06 ± 4.02 mm<sup>2</sup>/day in the early WH group and 2.71 ± 0.88 mm<sup>2</sup>/day in the late group. This difference reached statistical significance (<i>p</i> < 0.001). Moreover, WBC counts were significantly higher and serum levels of CRP and ESR were significantly lower in the early WH group than in the late group (<i>p</i> = 0.027, 0.036 and 0.043, respectively). <i>Conclusions</i>: Our results indicate that WBC as well as serum CRP and ESR levels have a significant correlation with WHR in diabetic patients.https://www.mdpi.com/1648-9144/58/3/390wounds and injurieswound healingdiabetes mellitusinflammation |
| spellingShingle | Yukwan Song Yongkyu Jo Jeongeun Sohn Robert Kim A Pilot Study to Explore a Correlation between Inflammatory Markers and the Wound Healing Rate in Diabetic Patients Medicina wounds and injuries wound healing diabetes mellitus inflammation |
| title | A Pilot Study to Explore a Correlation between Inflammatory Markers and the Wound Healing Rate in Diabetic Patients |
| title_full | A Pilot Study to Explore a Correlation between Inflammatory Markers and the Wound Healing Rate in Diabetic Patients |
| title_fullStr | A Pilot Study to Explore a Correlation between Inflammatory Markers and the Wound Healing Rate in Diabetic Patients |
| title_full_unstemmed | A Pilot Study to Explore a Correlation between Inflammatory Markers and the Wound Healing Rate in Diabetic Patients |
| title_short | A Pilot Study to Explore a Correlation between Inflammatory Markers and the Wound Healing Rate in Diabetic Patients |
| title_sort | pilot study to explore a correlation between inflammatory markers and the wound healing rate in diabetic patients |
| topic | wounds and injuries wound healing diabetes mellitus inflammation |
| url | https://www.mdpi.com/1648-9144/58/3/390 |
| work_keys_str_mv | AT yukwansong apilotstudytoexploreacorrelationbetweeninflammatorymarkersandthewoundhealingrateindiabeticpatients AT yongkyujo apilotstudytoexploreacorrelationbetweeninflammatorymarkersandthewoundhealingrateindiabeticpatients AT jeongeunsohn apilotstudytoexploreacorrelationbetweeninflammatorymarkersandthewoundhealingrateindiabeticpatients AT robertkim apilotstudytoexploreacorrelationbetweeninflammatorymarkersandthewoundhealingrateindiabeticpatients AT yukwansong pilotstudytoexploreacorrelationbetweeninflammatorymarkersandthewoundhealingrateindiabeticpatients AT yongkyujo pilotstudytoexploreacorrelationbetweeninflammatorymarkersandthewoundhealingrateindiabeticpatients AT jeongeunsohn pilotstudytoexploreacorrelationbetweeninflammatorymarkersandthewoundhealingrateindiabeticpatients AT robertkim pilotstudytoexploreacorrelationbetweeninflammatorymarkersandthewoundhealingrateindiabeticpatients |