23-Hydroxyursolic Acid Isolated from the Stem Bark of <i>Cussonia bancoensis</i> Induces Apoptosis through Fas/Caspase-8-Dependent Pathway in HL-60 Human Promyelocytic Leukemia Cells

23-Hydroxyursolic Acid Isolated from the Stem Bark of <i>Cussonia bancoensis</i> Induces Apoptosis through Fas/Caspase-8-Dependent Pathway in HL-60 Human Promyelocytic Leukemia Cells

The natural product 23-hydroxyursolic acid (23-HUA) is a derivative of ursolic acid, which is known to induce cancer cell apoptosis. However, apoptotic effects and mechanisms of 23-HUA have not been well characterized yet. Herein, we investigated the molecular mechanisms of 23-HUA-induced apoptosis...

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Bibliographic Details
Main Authors: Jong-Heon Won, Kyung-Sook Chung, Eun-Young Park, Jeong-Hun Lee, Jung-Hye Choi, Leon Azefack Tapondjou, Hee-Juhn Park, Masaaki Nomura, Ahmed H.E. Hassan, Kyung-Tae Lee
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Molecules
Subjects:
23-hydroxyursolic acid
apoptosis
caspase
Bcl-2
mitochondria
death-inducing signaling complex
Online Access:https://www.mdpi.com/1420-3049/23/12/3306

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