A Randomized Control Trial to Compare Hemodynamic Parameters of Patients Undergoing Percutaneous Nephrolithotomy Under Combined Spinal-Epidural and General Anesthesia in a Tertiary Hospital
Ksheerabdhi Sankar, Kuppusamy Anand, Swetha Ramani, Balasubramaniam Gayathri Department of Anesthesiology, SRM Medical College Hospital and Research Centre, Potheri, 603203, IndiaCorrespondence: Kuppusamy Anand, Department of Anesthesiology, SRM Medical College Hospital and Research Centre, Room No....
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Dove Medical Press
2023-05-01
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| Series: | Local and Regional Anesthesia |
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| Online Access: | https://www.dovepress.com/a-randomized-control-trial-to-compare-hemodynamic-parameters-of-patien-peer-reviewed-fulltext-article-LRA |
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| author | Sankar K Anand K Ramani S Gayathri B |
| author_facet | Sankar K Anand K Ramani S Gayathri B |
| author_sort | Sankar K |
| collection | DOAJ |
| description | Ksheerabdhi Sankar, Kuppusamy Anand, Swetha Ramani, Balasubramaniam Gayathri Department of Anesthesiology, SRM Medical College Hospital and Research Centre, Potheri, 603203, IndiaCorrespondence: Kuppusamy Anand, Department of Anesthesiology, SRM Medical College Hospital and Research Centre, Room No. 206, B Block, Second Floor, Potheri, 603203, India, Tel +91-98652 82288, Email anandk@srmist.edu.inBackground and Aim: Percutaneous nephrolithotomy (PCNL) under epidural anesthesia has been reported to have few advantages over general anesthesia, like lower postoperative pain and less need for analgesics. There are limited studies on PCNL being performed under neuraxial anesthesia in supine position. Hence the present study was conceived to compare hemodynamic parameters in patients undergoing percutaneous nephrolithotomy (PCNL) in the supine position under combined spinal-epidural with general anesthesia (GA).Material and Methods: A prospective, randomized control trial was conducted among 90 patients who were posted to undergo elective percutaneous nephrolithotomy in the the supine position, after obtaining Institutional Ethical Committee (IEC) approval and CTRI (Clinical Trial Registry - India) registration. Patients were randomly allotted to undergo surgery either under general anesthesia (group GA) or combined spinal epidural anesthesia (group CSE) by computer-generated random number method. Hemodynamic parameters, postoperative analgesic requirement and incidence of blood transfusion were recorded and analyzed.Results: There was no significant difference between the two groups with respect to gender, ASA grade, surgery duration, calculus size and pulse rate. There was a statistically significant reduction in mean arterial pressure from 5 to 50 minutes of surgery and less incidence of blood transfusion in patients in the CSE group. Patients who underwent PCNL in the supine position under CSE required lesser analgesics postoperatively compared to those under general anesthesia.Conclusion: Combined spinal epidural analgesia can be used as an alternative to general anesthesia for patients undergoing PCNL in the supine position in view of less MAP and reduced postoperative analgesic and blood transfusion requirement.Keywords: pulse rate, mean arterial pressure, percutaneous nephrolithotomy, ureteroscopy, supine position |
| first_indexed | 2024-03-13T10:29:35Z |
| format | Article |
| id | doaj.art-10879cb9c58b4e599760fca41dbf2272 |
| institution | Directory Open Access Journal |
| issn | 1178-7112 |
| language | English |
| last_indexed | 2024-03-13T10:29:35Z |
| publishDate | 2023-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Local and Regional Anesthesia |
| spelling | doaj.art-10879cb9c58b4e599760fca41dbf22722023-05-18T18:42:34ZengDove Medical PressLocal and Regional Anesthesia1178-71122023-05-01Volume 16414983818A Randomized Control Trial to Compare Hemodynamic Parameters of Patients Undergoing Percutaneous Nephrolithotomy Under Combined Spinal-Epidural and General Anesthesia in a Tertiary HospitalSankar KAnand KRamani SGayathri BKsheerabdhi Sankar, Kuppusamy Anand, Swetha Ramani, Balasubramaniam Gayathri Department of Anesthesiology, SRM Medical College Hospital and Research Centre, Potheri, 603203, IndiaCorrespondence: Kuppusamy Anand, Department of Anesthesiology, SRM Medical College Hospital and Research Centre, Room No. 206, B Block, Second Floor, Potheri, 603203, India, Tel +91-98652 82288, Email anandk@srmist.edu.inBackground and Aim: Percutaneous nephrolithotomy (PCNL) under epidural anesthesia has been reported to have few advantages over general anesthesia, like lower postoperative pain and less need for analgesics. There are limited studies on PCNL being performed under neuraxial anesthesia in supine position. Hence the present study was conceived to compare hemodynamic parameters in patients undergoing percutaneous nephrolithotomy (PCNL) in the supine position under combined spinal-epidural with general anesthesia (GA).Material and Methods: A prospective, randomized control trial was conducted among 90 patients who were posted to undergo elective percutaneous nephrolithotomy in the the supine position, after obtaining Institutional Ethical Committee (IEC) approval and CTRI (Clinical Trial Registry - India) registration. Patients were randomly allotted to undergo surgery either under general anesthesia (group GA) or combined spinal epidural anesthesia (group CSE) by computer-generated random number method. Hemodynamic parameters, postoperative analgesic requirement and incidence of blood transfusion were recorded and analyzed.Results: There was no significant difference between the two groups with respect to gender, ASA grade, surgery duration, calculus size and pulse rate. There was a statistically significant reduction in mean arterial pressure from 5 to 50 minutes of surgery and less incidence of blood transfusion in patients in the CSE group. Patients who underwent PCNL in the supine position under CSE required lesser analgesics postoperatively compared to those under general anesthesia.Conclusion: Combined spinal epidural analgesia can be used as an alternative to general anesthesia for patients undergoing PCNL in the supine position in view of less MAP and reduced postoperative analgesic and blood transfusion requirement.Keywords: pulse rate, mean arterial pressure, percutaneous nephrolithotomy, ureteroscopy, supine positionhttps://www.dovepress.com/a-randomized-control-trial-to-compare-hemodynamic-parameters-of-patien-peer-reviewed-fulltext-article-LRApulse ratemean arterial pressurepercutaneous nephrolithotomyureteroscopysupine position |
| spellingShingle | Sankar K Anand K Ramani S Gayathri B A Randomized Control Trial to Compare Hemodynamic Parameters of Patients Undergoing Percutaneous Nephrolithotomy Under Combined Spinal-Epidural and General Anesthesia in a Tertiary Hospital Local and Regional Anesthesia pulse rate mean arterial pressure percutaneous nephrolithotomy ureteroscopy supine position |
| title | A Randomized Control Trial to Compare Hemodynamic Parameters of Patients Undergoing Percutaneous Nephrolithotomy Under Combined Spinal-Epidural and General Anesthesia in a Tertiary Hospital |
| title_full | A Randomized Control Trial to Compare Hemodynamic Parameters of Patients Undergoing Percutaneous Nephrolithotomy Under Combined Spinal-Epidural and General Anesthesia in a Tertiary Hospital |
| title_fullStr | A Randomized Control Trial to Compare Hemodynamic Parameters of Patients Undergoing Percutaneous Nephrolithotomy Under Combined Spinal-Epidural and General Anesthesia in a Tertiary Hospital |
| title_full_unstemmed | A Randomized Control Trial to Compare Hemodynamic Parameters of Patients Undergoing Percutaneous Nephrolithotomy Under Combined Spinal-Epidural and General Anesthesia in a Tertiary Hospital |
| title_short | A Randomized Control Trial to Compare Hemodynamic Parameters of Patients Undergoing Percutaneous Nephrolithotomy Under Combined Spinal-Epidural and General Anesthesia in a Tertiary Hospital |
| title_sort | randomized control trial to compare hemodynamic parameters of patients undergoing percutaneous nephrolithotomy under combined spinal epidural and general anesthesia in a tertiary hospital |
| topic | pulse rate mean arterial pressure percutaneous nephrolithotomy ureteroscopy supine position |
| url | https://www.dovepress.com/a-randomized-control-trial-to-compare-hemodynamic-parameters-of-patien-peer-reviewed-fulltext-article-LRA |
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