Bioavailability of Coenzyme Q<sub>10</sub>: An Overview of the Absorption Process and Subsequent Metabolism
A lack of understanding of the processes determining the absorption and subsequent metabolism of coenzyme Q<sub>10</sub> (CoQ<sub>10</sub>) has resulted in some manufacturers’ making incorrect claims regarding the bioavailability of their CoQ<sub>10</sub> suppleme...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/9/5/386 |
| _version_ | 1827717410655830016 |
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| author | David Mantle Alex Dybring |
| author_facet | David Mantle Alex Dybring |
| author_sort | David Mantle |
| collection | DOAJ |
| description | A lack of understanding of the processes determining the absorption and subsequent metabolism of coenzyme Q<sub>10</sub> (CoQ<sub>10</sub>) has resulted in some manufacturers’ making incorrect claims regarding the bioavailability of their CoQ<sub>10</sub> supplements, with potential consequences for the use of such products in clinical trials. The purpose of the present review article is, therefore, to describe the various stages of exogenous CoQ<sub>10</sub> metabolism, from its first ingestion, stomach transit, absorption from the small intestine into the lymphatic system, transport in blood, and access into cells. In particular, the importance of CoQ<sub>10</sub> crystal dispersion in the initial formulation is emphasised, the absence of which reduces bioavailability by 75%. In addition, evidence comparing the relative bioavailability and efficacy of ubiquinone and ubiquinol forms of CoQ<sub>10</sub> has been reviewed. |
| first_indexed | 2024-03-10T20:01:00Z |
| format | Article |
| id | doaj.art-1088456abb99421d910db648bbc9ba06 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T20:01:00Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-1088456abb99421d910db648bbc9ba062023-11-19T23:33:23ZengMDPI AGAntioxidants2076-39212020-05-019538610.3390/antiox9050386Bioavailability of Coenzyme Q<sub>10</sub>: An Overview of the Absorption Process and Subsequent MetabolismDavid Mantle0Alex Dybring1Pharma Nord (UK) Ltd., Telford Court, Morpeth, Northumberland NE61 2DB, UKPharma Nord (DK) ApS, Sadelmagervej 30-32, DK-7100 Vejle, DenmarkA lack of understanding of the processes determining the absorption and subsequent metabolism of coenzyme Q<sub>10</sub> (CoQ<sub>10</sub>) has resulted in some manufacturers’ making incorrect claims regarding the bioavailability of their CoQ<sub>10</sub> supplements, with potential consequences for the use of such products in clinical trials. The purpose of the present review article is, therefore, to describe the various stages of exogenous CoQ<sub>10</sub> metabolism, from its first ingestion, stomach transit, absorption from the small intestine into the lymphatic system, transport in blood, and access into cells. In particular, the importance of CoQ<sub>10</sub> crystal dispersion in the initial formulation is emphasised, the absence of which reduces bioavailability by 75%. In addition, evidence comparing the relative bioavailability and efficacy of ubiquinone and ubiquinol forms of CoQ<sub>10</sub> has been reviewed.https://www.mdpi.com/2076-3921/9/5/386coenzyme Q<sub>10</sub>bioavailabilityubiquinoneubiquinolabsorptiontransport |
| spellingShingle | David Mantle Alex Dybring Bioavailability of Coenzyme Q<sub>10</sub>: An Overview of the Absorption Process and Subsequent Metabolism Antioxidants coenzyme Q<sub>10</sub> bioavailability ubiquinone ubiquinol absorption transport |
| title | Bioavailability of Coenzyme Q<sub>10</sub>: An Overview of the Absorption Process and Subsequent Metabolism |
| title_full | Bioavailability of Coenzyme Q<sub>10</sub>: An Overview of the Absorption Process and Subsequent Metabolism |
| title_fullStr | Bioavailability of Coenzyme Q<sub>10</sub>: An Overview of the Absorption Process and Subsequent Metabolism |
| title_full_unstemmed | Bioavailability of Coenzyme Q<sub>10</sub>: An Overview of the Absorption Process and Subsequent Metabolism |
| title_short | Bioavailability of Coenzyme Q<sub>10</sub>: An Overview of the Absorption Process and Subsequent Metabolism |
| title_sort | bioavailability of coenzyme q sub 10 sub an overview of the absorption process and subsequent metabolism |
| topic | coenzyme Q<sub>10</sub> bioavailability ubiquinone ubiquinol absorption transport |
| url | https://www.mdpi.com/2076-3921/9/5/386 |
| work_keys_str_mv | AT davidmantle bioavailabilityofcoenzymeqsub10subanoverviewoftheabsorptionprocessandsubsequentmetabolism AT alexdybring bioavailabilityofcoenzymeqsub10subanoverviewoftheabsorptionprocessandsubsequentmetabolism |