Causal association between metabolic syndrome and cholelithiasis: a Mendelian randomization study
BackgroundMetabolic syndrome (MetS) has been associated with digestive system diseases, and recent observational studies have suggested an association between MetS and cholelithiasis. However, the causal relationship between them remains unclear. This study aimed to assess the causal effect of MetS...
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| Format: | Article |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1180903/full |
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| author | Qi Zhu Yawei Xing Yunfeng Fu Xiaqin Chen Langyi Guan Foqiang Liao Xiaodong Zhou |
| author_facet | Qi Zhu Yawei Xing Yunfeng Fu Xiaqin Chen Langyi Guan Foqiang Liao Xiaodong Zhou |
| author_sort | Qi Zhu |
| collection | DOAJ |
| description | BackgroundMetabolic syndrome (MetS) has been associated with digestive system diseases, and recent observational studies have suggested an association between MetS and cholelithiasis. However, the causal relationship between them remains unclear. This study aimed to assess the causal effect of MetS on cholelithiasis using Mendelian randomization (MR) analysis.MethodsSingle nucleotide polymorphisms (SNPs) of MetS and its components were extracted from the public genetic variation summary database. The inverse variance weighting method (IVW), weighted median method, and MR-Egger regression were used to evaluate the causal relationship. A sensitivity analysis was performed to ensure the stability of the results.ResultsIVW showed that MetS increased the risk of cholelithiasis (OR = 1.28, 95% CI = 1.13–1.46, P = 9.70E−05), and the weighted median method had the same result (OR = 1.49, 95% CI = 1.22–1.83, P = 5.68E−05). In exploring the causal relationship between MetS components and cholelithiasis, waist circumference (WC) was significantly associated with cholelithiasis. IVW analysis (OR = 1.48, 95% CI = 1.34–1.65, P = 1.15E−13), MR-Egger regression (OR = 1.62, 95% CI = 1.15–2.28, P = 0.007), and weighted median (OR = 1.73, 95% CI = 1.47–2.04, P = 1.62E−11) all found the same results.ConclusionOur study indicated that MetS increases the incidence of cholelithiasis, especially in MetS patients with abdominal obesity. Control and treatment of MetS can effectively reduce the risk of gallstone formation. |
| first_indexed | 2024-03-13T06:35:40Z |
| format | Article |
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| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-13T06:35:40Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj.art-108aeaafb7f24465b40f3ca46673af7e2023-06-09T04:47:15ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-06-011410.3389/fendo.2023.11809031180903Causal association between metabolic syndrome and cholelithiasis: a Mendelian randomization studyQi ZhuYawei XingYunfeng FuXiaqin ChenLangyi GuanFoqiang LiaoXiaodong ZhouBackgroundMetabolic syndrome (MetS) has been associated with digestive system diseases, and recent observational studies have suggested an association between MetS and cholelithiasis. However, the causal relationship between them remains unclear. This study aimed to assess the causal effect of MetS on cholelithiasis using Mendelian randomization (MR) analysis.MethodsSingle nucleotide polymorphisms (SNPs) of MetS and its components were extracted from the public genetic variation summary database. The inverse variance weighting method (IVW), weighted median method, and MR-Egger regression were used to evaluate the causal relationship. A sensitivity analysis was performed to ensure the stability of the results.ResultsIVW showed that MetS increased the risk of cholelithiasis (OR = 1.28, 95% CI = 1.13–1.46, P = 9.70E−05), and the weighted median method had the same result (OR = 1.49, 95% CI = 1.22–1.83, P = 5.68E−05). In exploring the causal relationship between MetS components and cholelithiasis, waist circumference (WC) was significantly associated with cholelithiasis. IVW analysis (OR = 1.48, 95% CI = 1.34–1.65, P = 1.15E−13), MR-Egger regression (OR = 1.62, 95% CI = 1.15–2.28, P = 0.007), and weighted median (OR = 1.73, 95% CI = 1.47–2.04, P = 1.62E−11) all found the same results.ConclusionOur study indicated that MetS increases the incidence of cholelithiasis, especially in MetS patients with abdominal obesity. Control and treatment of MetS can effectively reduce the risk of gallstone formation.https://www.frontiersin.org/articles/10.3389/fendo.2023.1180903/fullcholelithiasisobesitymetabolic syndromeabdominal obesityMendelian randomization |
| spellingShingle | Qi Zhu Yawei Xing Yunfeng Fu Xiaqin Chen Langyi Guan Foqiang Liao Xiaodong Zhou Causal association between metabolic syndrome and cholelithiasis: a Mendelian randomization study Frontiers in Endocrinology cholelithiasis obesity metabolic syndrome abdominal obesity Mendelian randomization |
| title | Causal association between metabolic syndrome and cholelithiasis: a Mendelian randomization study |
| title_full | Causal association between metabolic syndrome and cholelithiasis: a Mendelian randomization study |
| title_fullStr | Causal association between metabolic syndrome and cholelithiasis: a Mendelian randomization study |
| title_full_unstemmed | Causal association between metabolic syndrome and cholelithiasis: a Mendelian randomization study |
| title_short | Causal association between metabolic syndrome and cholelithiasis: a Mendelian randomization study |
| title_sort | causal association between metabolic syndrome and cholelithiasis a mendelian randomization study |
| topic | cholelithiasis obesity metabolic syndrome abdominal obesity Mendelian randomization |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1180903/full |
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