Enhanced sensitivity to ethanol-induced inhibition of LTP in CA1 pyramidal neurons of socially isolated C57BL/6J mice: role of neurosteroids

Enhanced sensitivity to ethanol-induced inhibition of LTP in CA1 pyramidal neurons of socially isolated C57BL/6J mice: role of neurosteroids

Ethanol (EtOH)–induced impairment of long-term potentiation (LTP) in the rat hippocampus is prevented by the 5α-reductase inhibitor finasteride, suggesting that this effect of EtOH is dependent on the increased local release of neurosteroids such as 3α,5α-THP that promote GABA–mediated transmission....

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Bibliographic Details
Main Authors: Giuseppe eTalani, Giovanni eBiggio, Enrico eSanna
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-10-01
Series:Frontiers in Endocrinology
Subjects:
Ethanol
Hippocampus
Social Isolation
LTP
stress
Neuronal excitability
Online Access:http://journal.frontiersin.org/Journal/10.3389/fendo.2011.00056/full

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