Colon Rectal Liver Metastases: The Role of the Liver Transplantation in the Era of the Transplant Oncology and Precision Medicine
The development of liver metastases in colon rectal cancer has a strong impact on the overall survival (OS) of the patient, with a 5-year survival rate of 5% with palliative treatment. Surgical resection combined with pharmacological treatment can achieve a 5-year OS rate of 31–58%. However, in only...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-07-01
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| Series: | Frontiers in Surgery |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fsurg.2021.693387/full |
| _version_ | 1829133840095903744 |
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| author | Michele Finotti Alessandro Vitale Enrico Gringeri Francesco Enrico D'Amico Riccardo Boetto Alessandra Bertacco Sara Lonardi Francesca Bergamo Paolo Feltracco Umberto Cillo |
| author_facet | Michele Finotti Alessandro Vitale Enrico Gringeri Francesco Enrico D'Amico Riccardo Boetto Alessandra Bertacco Sara Lonardi Francesca Bergamo Paolo Feltracco Umberto Cillo |
| author_sort | Michele Finotti |
| collection | DOAJ |
| description | The development of liver metastases in colon rectal cancer has a strong impact on the overall survival (OS) of the patient, with a 5-year survival rate of 5% with palliative treatment. Surgical resection combined with pharmacological treatment can achieve a 5-year OS rate of 31–58%. However, in only 20% of patients with colon rectal liver metastases (CRLMs), liver resection is feasible. In highly selected patients, recent trials and studies proved that liver transplantation (LT) for non-resectable CRLM is a surgical option with an excellent long-term OS. The paper aims to review the indications and outcome of LT for CRLMs, with a special focus on immunosuppressive therapy and the management of local and extrahepatic recurrence after LT. |
| first_indexed | 2024-12-14T17:49:55Z |
| format | Article |
| id | doaj.art-108e6fc8867c44f3beb4b678c353e147 |
| institution | Directory Open Access Journal |
| issn | 2296-875X |
| language | English |
| last_indexed | 2024-12-14T17:49:55Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Surgery |
| spelling | doaj.art-108e6fc8867c44f3beb4b678c353e1472022-12-21T22:52:39ZengFrontiers Media S.A.Frontiers in Surgery2296-875X2021-07-01810.3389/fsurg.2021.693387693387Colon Rectal Liver Metastases: The Role of the Liver Transplantation in the Era of the Transplant Oncology and Precision MedicineMichele Finotti0Alessandro Vitale1Enrico Gringeri2Francesco Enrico D'Amico3Riccardo Boetto4Alessandra Bertacco5Sara Lonardi6Francesca Bergamo7Paolo Feltracco8Umberto Cillo9University of Padova, Transplantation and Hepatobiliary Surgery, Padua, ItalyUniversity of Padova, Transplantation and Hepatobiliary Surgery, Padua, ItalyUniversity of Padova, Transplantation and Hepatobiliary Surgery, Padua, ItalyUniversity of Padova, Transplantation and Hepatobiliary Surgery, Padua, ItalyUniversity of Padova, Transplantation and Hepatobiliary Surgery, Padua, ItalyUniversity of Padova, Transplantation and Hepatobiliary Surgery, Padua, ItalyUnit of Oncology 1, Department of Oncology, Veneto Institute of Oncology IOV - Istituto di Ricovero e Cura a Carattere Scientifico, Padua, ItalyUnit of Oncology 1, Department of Oncology, Veneto Institute of Oncology IOV - Istituto di Ricovero e Cura a Carattere Scientifico, Padua, ItalyAnesthesia and Intensive Care Unit, Azienda Ospedaliera di Padova, Padua, ItalyUniversity of Padova, Transplantation and Hepatobiliary Surgery, Padua, ItalyThe development of liver metastases in colon rectal cancer has a strong impact on the overall survival (OS) of the patient, with a 5-year survival rate of 5% with palliative treatment. Surgical resection combined with pharmacological treatment can achieve a 5-year OS rate of 31–58%. However, in only 20% of patients with colon rectal liver metastases (CRLMs), liver resection is feasible. In highly selected patients, recent trials and studies proved that liver transplantation (LT) for non-resectable CRLM is a surgical option with an excellent long-term OS. The paper aims to review the indications and outcome of LT for CRLMs, with a special focus on immunosuppressive therapy and the management of local and extrahepatic recurrence after LT.https://www.frontiersin.org/articles/10.3389/fsurg.2021.693387/fullliver resectiontransplant benefitprioritizationimmunosopressive therapyrecurrence |
| spellingShingle | Michele Finotti Alessandro Vitale Enrico Gringeri Francesco Enrico D'Amico Riccardo Boetto Alessandra Bertacco Sara Lonardi Francesca Bergamo Paolo Feltracco Umberto Cillo Colon Rectal Liver Metastases: The Role of the Liver Transplantation in the Era of the Transplant Oncology and Precision Medicine Frontiers in Surgery liver resection transplant benefit prioritization immunosopressive therapy recurrence |
| title | Colon Rectal Liver Metastases: The Role of the Liver Transplantation in the Era of the Transplant Oncology and Precision Medicine |
| title_full | Colon Rectal Liver Metastases: The Role of the Liver Transplantation in the Era of the Transplant Oncology and Precision Medicine |
| title_fullStr | Colon Rectal Liver Metastases: The Role of the Liver Transplantation in the Era of the Transplant Oncology and Precision Medicine |
| title_full_unstemmed | Colon Rectal Liver Metastases: The Role of the Liver Transplantation in the Era of the Transplant Oncology and Precision Medicine |
| title_short | Colon Rectal Liver Metastases: The Role of the Liver Transplantation in the Era of the Transplant Oncology and Precision Medicine |
| title_sort | colon rectal liver metastases the role of the liver transplantation in the era of the transplant oncology and precision medicine |
| topic | liver resection transplant benefit prioritization immunosopressive therapy recurrence |
| url | https://www.frontiersin.org/articles/10.3389/fsurg.2021.693387/full |
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