Six Highly Conserved Targets of RNAi Revealed in HIV-1-Infected Patients from Russia Are Also Present in Many HIV-1 Strains Worldwide

Six Highly Conserved Targets of RNAi Revealed in HIV-1-Infected Patients from Russia Are Also Present in Many HIV-1 Strains Worldwide

RNAi has been suggested for use in gene therapy of HIV/AIDS, but the main problem is that HIV-1 is highly variable and could escape attack from the small interfering RNAs (siRNAs) due to even single nucleotide substitutions in the potential targets. To exhaustively check the variability in selected...

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Bibliographic Details
Main Authors: Olga V. Kretova, Daria M. Fedoseeva, Maria A. Gorbacheva, Natalya M. Gashnikova, Maria P. Gashnikova, Nataliya V. Melnikova, Vladimir R. Chechetkin, Yuri V. Kravatsky, Nickolai A. Tchurikov
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Molecular Therapy: Nucleic Acids
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253117302202

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