Emerging strategies in nanotechnology to treat respiratory tract infections: realizing current trends for future clinical perspectives
A boom in respiratory tract infection cases has inflicted a socio-economic burden on the healthcare system worldwide, especially in developing countries. Limited alternative therapeutic options have posed a major threat to human health. Nanotechnology has brought an immense breakthrough in the pharm...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2022-12-01
|
| Series: | Drug Delivery |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/10717544.2022.2089294 |
| _version_ | 1818002425746817024 |
|---|---|
| author | Minhua Chen Zhangxuan Shou Xue Jin Yingjun Chen |
| author_facet | Minhua Chen Zhangxuan Shou Xue Jin Yingjun Chen |
| author_sort | Minhua Chen |
| collection | DOAJ |
| description | A boom in respiratory tract infection cases has inflicted a socio-economic burden on the healthcare system worldwide, especially in developing countries. Limited alternative therapeutic options have posed a major threat to human health. Nanotechnology has brought an immense breakthrough in the pharmaceutical industry in a jiffy. The vast applications of nanotechnology ranging from early diagnosis to treatment strategies are employed for respiratory tract infections. The research avenues explored a multitude of nanosystems for effective drug delivery to the target site and combating the issues laid through multidrug resistance and protective niches of the bacteria. In this review a brief introduction to respiratory diseases and multifaceted barriers imposed by bacterial infections are enlightened. The manuscript reviewed different nanosystems, i.e. liposomes, solid lipid nanoparticles, polymeric nanoparticles, dendrimers, nanogels, and metallic (gold and silver) which enhanced bactericidal effects, prevented biofilm formation, improved mucus penetration, and site-specific delivery. Moreover, most of the nanotechnology-based recent research is in a preclinical and clinical experimental stage and safety assessment is still challenging. |
| first_indexed | 2024-04-14T03:45:45Z |
| format | Article |
| id | doaj.art-109105aaad2c4f6ba5407176d1feb1f1 |
| institution | Directory Open Access Journal |
| issn | 1071-7544 1521-0464 |
| language | English |
| last_indexed | 2024-04-14T03:45:45Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Drug Delivery |
| spelling | doaj.art-109105aaad2c4f6ba5407176d1feb1f12022-12-22T02:14:15ZengTaylor & Francis GroupDrug Delivery1071-75441521-04642022-12-012912442245810.1080/10717544.2022.2089294Emerging strategies in nanotechnology to treat respiratory tract infections: realizing current trends for future clinical perspectivesMinhua Chen0Zhangxuan Shou1Xue Jin2Yingjun Chen3Emergency & Intensive Care Unit Center, Department of Intensive Care Unit, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, ChinaDepartment of Pharmacy, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaCenter for Clinical Pharmacy, Cancer Center, Department of Pharmacy, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College), Hangzhou, ChinaDepartment of Infectious Diseases, People’s Hospital of Tiantai County, Taizhou, ChinaA boom in respiratory tract infection cases has inflicted a socio-economic burden on the healthcare system worldwide, especially in developing countries. Limited alternative therapeutic options have posed a major threat to human health. Nanotechnology has brought an immense breakthrough in the pharmaceutical industry in a jiffy. The vast applications of nanotechnology ranging from early diagnosis to treatment strategies are employed for respiratory tract infections. The research avenues explored a multitude of nanosystems for effective drug delivery to the target site and combating the issues laid through multidrug resistance and protective niches of the bacteria. In this review a brief introduction to respiratory diseases and multifaceted barriers imposed by bacterial infections are enlightened. The manuscript reviewed different nanosystems, i.e. liposomes, solid lipid nanoparticles, polymeric nanoparticles, dendrimers, nanogels, and metallic (gold and silver) which enhanced bactericidal effects, prevented biofilm formation, improved mucus penetration, and site-specific delivery. Moreover, most of the nanotechnology-based recent research is in a preclinical and clinical experimental stage and safety assessment is still challenging.https://www.tandfonline.com/doi/10.1080/10717544.2022.2089294Respiratory tract infectionsbacterial infectionssmart nanosystemsnanodiagnostics |
| spellingShingle | Minhua Chen Zhangxuan Shou Xue Jin Yingjun Chen Emerging strategies in nanotechnology to treat respiratory tract infections: realizing current trends for future clinical perspectives Drug Delivery Respiratory tract infections bacterial infections smart nanosystems nanodiagnostics |
| title | Emerging strategies in nanotechnology to treat respiratory tract infections: realizing current trends for future clinical perspectives |
| title_full | Emerging strategies in nanotechnology to treat respiratory tract infections: realizing current trends for future clinical perspectives |
| title_fullStr | Emerging strategies in nanotechnology to treat respiratory tract infections: realizing current trends for future clinical perspectives |
| title_full_unstemmed | Emerging strategies in nanotechnology to treat respiratory tract infections: realizing current trends for future clinical perspectives |
| title_short | Emerging strategies in nanotechnology to treat respiratory tract infections: realizing current trends for future clinical perspectives |
| title_sort | emerging strategies in nanotechnology to treat respiratory tract infections realizing current trends for future clinical perspectives |
| topic | Respiratory tract infections bacterial infections smart nanosystems nanodiagnostics |
| url | https://www.tandfonline.com/doi/10.1080/10717544.2022.2089294 |
| work_keys_str_mv | AT minhuachen emergingstrategiesinnanotechnologytotreatrespiratorytractinfectionsrealizingcurrenttrendsforfutureclinicalperspectives AT zhangxuanshou emergingstrategiesinnanotechnologytotreatrespiratorytractinfectionsrealizingcurrenttrendsforfutureclinicalperspectives AT xuejin emergingstrategiesinnanotechnologytotreatrespiratorytractinfectionsrealizingcurrenttrendsforfutureclinicalperspectives AT yingjunchen emergingstrategiesinnanotechnologytotreatrespiratorytractinfectionsrealizingcurrenttrendsforfutureclinicalperspectives |