Stress Across Generations: DNA Methylation as a Potential Mechanism Underlying Intergenerational Effects of Stress in Both Post-traumatic Stress Disorder and Pre-clinical Predator Stress Rodent Models
Although most humans will experience some type of traumatic event in their lifetime only a small set of individuals will go on to develop post-traumatic stress disorder (PTSD). Differences in sex, age, trauma type, and comorbidity, along with many other elements, contribute to the heterogenous manif...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2019-05-01
|
| Series: | Frontiers in Behavioral Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fnbeh.2019.00113/full |
| _version_ | 1818320023826989056 |
|---|---|
| author | Sriya Bhattacharya Audrey Fontaine Audrey Fontaine Phillip E. MacCallum James Drover Jacqueline Blundell |
| author_facet | Sriya Bhattacharya Audrey Fontaine Audrey Fontaine Phillip E. MacCallum James Drover Jacqueline Blundell |
| author_sort | Sriya Bhattacharya |
| collection | DOAJ |
| description | Although most humans will experience some type of traumatic event in their lifetime only a small set of individuals will go on to develop post-traumatic stress disorder (PTSD). Differences in sex, age, trauma type, and comorbidity, along with many other elements, contribute to the heterogenous manifestation of this disorder. Nonetheless, aberrant hypothalamus-pituitary-adrenal (HPA) axis activity, especially in terms of cortisol and glucocorticoid receptor (GR) alterations, has been postulated as a tenable factor in the etiology and pathophysiology of PTSD. Moreover, emerging data suggests that the harmful effects of traumatic stress to the HPA axis in PTSD can also propagate into future generations, making offspring more prone to psychopathologies. Predator stress models provide an ethical and ethologically relevant way to investigate tentative mechanisms that are thought to underlie this phenomenon. In this review article, we discuss findings from human and laboratory predator stress studies that suggest changes to DNA methylation germane to GRs may underlie the generational effects of trauma transmission. Understanding mechanisms that promote stress-induced psychopathology will represent a major advance in the field and may lead to novel treatments for such devastating, and often treatment-resistant trauma and stress-disorders. |
| first_indexed | 2024-12-13T10:18:25Z |
| format | Article |
| id | doaj.art-1091dfe0eac44d8b80abc45c7b5a626c |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-12-13T10:18:25Z |
| publishDate | 2019-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-1091dfe0eac44d8b80abc45c7b5a626c2022-12-21T23:51:14ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532019-05-011310.3389/fnbeh.2019.00113441328Stress Across Generations: DNA Methylation as a Potential Mechanism Underlying Intergenerational Effects of Stress in Both Post-traumatic Stress Disorder and Pre-clinical Predator Stress Rodent ModelsSriya Bhattacharya0Audrey Fontaine1Audrey Fontaine2Phillip E. MacCallum3James Drover4Jacqueline Blundell5Department of Psychology, Memorial University of Newfoundland, St. John’s, NL, CanadaDepartment of Psychology, Memorial University of Newfoundland, St. John’s, NL, Canada Institut des Systèmes Intelligents et de Robotique (ISIR), Université Pierre et Marie Curie, Sorbonne Universités, Paris, FranceDepartment of Psychology, Memorial University of Newfoundland, St. John’s, NL, CanadaDepartment of Psychology, Memorial University of Newfoundland, St. John’s, NL, CanadaDepartment of Psychology, Memorial University of Newfoundland, St. John’s, NL, CanadaAlthough most humans will experience some type of traumatic event in their lifetime only a small set of individuals will go on to develop post-traumatic stress disorder (PTSD). Differences in sex, age, trauma type, and comorbidity, along with many other elements, contribute to the heterogenous manifestation of this disorder. Nonetheless, aberrant hypothalamus-pituitary-adrenal (HPA) axis activity, especially in terms of cortisol and glucocorticoid receptor (GR) alterations, has been postulated as a tenable factor in the etiology and pathophysiology of PTSD. Moreover, emerging data suggests that the harmful effects of traumatic stress to the HPA axis in PTSD can also propagate into future generations, making offspring more prone to psychopathologies. Predator stress models provide an ethical and ethologically relevant way to investigate tentative mechanisms that are thought to underlie this phenomenon. In this review article, we discuss findings from human and laboratory predator stress studies that suggest changes to DNA methylation germane to GRs may underlie the generational effects of trauma transmission. Understanding mechanisms that promote stress-induced psychopathology will represent a major advance in the field and may lead to novel treatments for such devastating, and often treatment-resistant trauma and stress-disorders.https://www.frontiersin.org/article/10.3389/fnbeh.2019.00113/fullPTSDpredator stressintergenerationalDNA methylationglucocorticoid receptorsFKBP5 |
| spellingShingle | Sriya Bhattacharya Audrey Fontaine Audrey Fontaine Phillip E. MacCallum James Drover Jacqueline Blundell Stress Across Generations: DNA Methylation as a Potential Mechanism Underlying Intergenerational Effects of Stress in Both Post-traumatic Stress Disorder and Pre-clinical Predator Stress Rodent Models Frontiers in Behavioral Neuroscience PTSD predator stress intergenerational DNA methylation glucocorticoid receptors FKBP5 |
| title | Stress Across Generations: DNA Methylation as a Potential Mechanism Underlying Intergenerational Effects of Stress in Both Post-traumatic Stress Disorder and Pre-clinical Predator Stress Rodent Models |
| title_full | Stress Across Generations: DNA Methylation as a Potential Mechanism Underlying Intergenerational Effects of Stress in Both Post-traumatic Stress Disorder and Pre-clinical Predator Stress Rodent Models |
| title_fullStr | Stress Across Generations: DNA Methylation as a Potential Mechanism Underlying Intergenerational Effects of Stress in Both Post-traumatic Stress Disorder and Pre-clinical Predator Stress Rodent Models |
| title_full_unstemmed | Stress Across Generations: DNA Methylation as a Potential Mechanism Underlying Intergenerational Effects of Stress in Both Post-traumatic Stress Disorder and Pre-clinical Predator Stress Rodent Models |
| title_short | Stress Across Generations: DNA Methylation as a Potential Mechanism Underlying Intergenerational Effects of Stress in Both Post-traumatic Stress Disorder and Pre-clinical Predator Stress Rodent Models |
| title_sort | stress across generations dna methylation as a potential mechanism underlying intergenerational effects of stress in both post traumatic stress disorder and pre clinical predator stress rodent models |
| topic | PTSD predator stress intergenerational DNA methylation glucocorticoid receptors FKBP5 |
| url | https://www.frontiersin.org/article/10.3389/fnbeh.2019.00113/full |
| work_keys_str_mv | AT sriyabhattacharya stressacrossgenerationsdnamethylationasapotentialmechanismunderlyingintergenerationaleffectsofstressinbothposttraumaticstressdisorderandpreclinicalpredatorstressrodentmodels AT audreyfontaine stressacrossgenerationsdnamethylationasapotentialmechanismunderlyingintergenerationaleffectsofstressinbothposttraumaticstressdisorderandpreclinicalpredatorstressrodentmodels AT audreyfontaine stressacrossgenerationsdnamethylationasapotentialmechanismunderlyingintergenerationaleffectsofstressinbothposttraumaticstressdisorderandpreclinicalpredatorstressrodentmodels AT phillipemaccallum stressacrossgenerationsdnamethylationasapotentialmechanismunderlyingintergenerationaleffectsofstressinbothposttraumaticstressdisorderandpreclinicalpredatorstressrodentmodels AT jamesdrover stressacrossgenerationsdnamethylationasapotentialmechanismunderlyingintergenerationaleffectsofstressinbothposttraumaticstressdisorderandpreclinicalpredatorstressrodentmodels AT jacquelineblundell stressacrossgenerationsdnamethylationasapotentialmechanismunderlyingintergenerationaleffectsofstressinbothposttraumaticstressdisorderandpreclinicalpredatorstressrodentmodels |