Effects of phosphatidylcholine and betaine supplements on women's serum choline
Background: Maternal phosphatidylcholine supplements have shown benefit in the development of the human fetal brain, as assessed both by newborn physiological measurements and by a related decrease in later childhood behavioral abnormalities. However, the relatively low choline component of phosphat...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-06-01
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| Series: | Journal of Nutrition & Intermediary Metabolism |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352385918300367 |
| _version_ | 1818989884915843072 |
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| author | M. Camille Hoffman Ann Olincy Angelo D'Alessandro Julie A. Reisz Kirk C. Hansen Sharon K. Hunter Robert Freedman Randal G. Ross |
| author_facet | M. Camille Hoffman Ann Olincy Angelo D'Alessandro Julie A. Reisz Kirk C. Hansen Sharon K. Hunter Robert Freedman Randal G. Ross |
| author_sort | M. Camille Hoffman |
| collection | DOAJ |
| description | Background: Maternal phosphatidylcholine supplements have shown benefit in the development of the human fetal brain, as assessed both by newborn physiological measurements and by a related decrease in later childhood behavioral abnormalities. However, the relatively low choline component of phosphatidylcholine mandates high doses that are difficult for pregnant women to consume. Objective: Betaine can substitute for some choline effects. The hypothesis was that betaine supplementation would significantly increase women's serum choline. Design: A three-arm crossover clinical trial was used to assess serum concentrations of choline after betaine supplements at two doses, in comparison with phosphatidylcholine supplementation. The effects of both a single dose and of one-week twice-daily doses were assessed in normal non-pregnant women. Results: Betaine supplements at two doses failed to increase serum choline concentrations after single administration or one-week twice-daily dosing. Phosphatidylcholine supplements raised choline concentrations after both single doses (mean change from baseline 8.34 ± 7.29 ng/ml, paired t = 3.24, df 7, p = 0.014, range 1–21 ng/ml, d’ = 1.15) and one-week twice-daily doses (mean change from baseline 4.58 ± 3.68 ng/ml standard deviation; paired t = 3.51, df 7, p < 0.001, range 2–13 ng/ml, d’ = 2.65). Betaine concentrations rose after both betaine and phosphatidylcholine supplementation. Conclusions: Betaine supplements did not substitute for phosphatidylcholine supplements, which raise serum choline concentrations both after a single dose and after repeated administration. However, serum betaine concentrations did rise after both betaine and phosphatidylcholine consumption and, therefore, betaine may be a stable indicator of choline intake. Keywords: Phosphatidylcholine, Choline, Betaine, Dimethylglycine, Pregnancy |
| first_indexed | 2024-12-20T19:45:35Z |
| format | Article |
| id | doaj.art-109357c9a3844c8e9f85ede1f8e29b20 |
| institution | Directory Open Access Journal |
| issn | 2352-3859 |
| language | English |
| last_indexed | 2024-12-20T19:45:35Z |
| publishDate | 2019-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Nutrition & Intermediary Metabolism |
| spelling | doaj.art-109357c9a3844c8e9f85ede1f8e29b202022-12-21T19:28:26ZengElsevierJournal of Nutrition & Intermediary Metabolism2352-38592019-06-0116Effects of phosphatidylcholine and betaine supplements on women's serum cholineM. Camille Hoffman0Ann Olincy1Angelo D'Alessandro2Julie A. Reisz3Kirk C. Hansen4Sharon K. Hunter5Robert Freedman6Randal G. Ross7Corresponding author. Department of Psychiatry Mail Stop F546, Anschutz Medical Campus, University of Colorado, Aurora CO, 80045, USA.; Department of Obstetrics and Gynecology (MCH), Psychiatry (MCH, AO, SKH, RF, RGR and Biochemistry Molecular Genetics (AD’A, JAR, KCH), University of Colorado School of Medicine, USADepartment of Obstetrics and Gynecology (MCH), Psychiatry (MCH, AO, SKH, RF, RGR and Biochemistry Molecular Genetics (AD’A, JAR, KCH), University of Colorado School of Medicine, USADepartment of Obstetrics and Gynecology (MCH), Psychiatry (MCH, AO, SKH, RF, RGR and Biochemistry Molecular Genetics (AD’A, JAR, KCH), University of Colorado School of Medicine, USADepartment of Obstetrics and Gynecology (MCH), Psychiatry (MCH, AO, SKH, RF, RGR and Biochemistry Molecular Genetics (AD’A, JAR, KCH), University of Colorado School of Medicine, USADepartment of Obstetrics and Gynecology (MCH), Psychiatry (MCH, AO, SKH, RF, RGR and Biochemistry Molecular Genetics (AD’A, JAR, KCH), University of Colorado School of Medicine, USADepartment of Obstetrics and Gynecology (MCH), Psychiatry (MCH, AO, SKH, RF, RGR and Biochemistry Molecular Genetics (AD’A, JAR, KCH), University of Colorado School of Medicine, USADepartment of Obstetrics and Gynecology (MCH), Psychiatry (MCH, AO, SKH, RF, RGR and Biochemistry Molecular Genetics (AD’A, JAR, KCH), University of Colorado School of Medicine, USADepartment of Obstetrics and Gynecology (MCH), Psychiatry (MCH, AO, SKH, RF, RGR and Biochemistry Molecular Genetics (AD’A, JAR, KCH), University of Colorado School of Medicine, USABackground: Maternal phosphatidylcholine supplements have shown benefit in the development of the human fetal brain, as assessed both by newborn physiological measurements and by a related decrease in later childhood behavioral abnormalities. However, the relatively low choline component of phosphatidylcholine mandates high doses that are difficult for pregnant women to consume. Objective: Betaine can substitute for some choline effects. The hypothesis was that betaine supplementation would significantly increase women's serum choline. Design: A three-arm crossover clinical trial was used to assess serum concentrations of choline after betaine supplements at two doses, in comparison with phosphatidylcholine supplementation. The effects of both a single dose and of one-week twice-daily doses were assessed in normal non-pregnant women. Results: Betaine supplements at two doses failed to increase serum choline concentrations after single administration or one-week twice-daily dosing. Phosphatidylcholine supplements raised choline concentrations after both single doses (mean change from baseline 8.34 ± 7.29 ng/ml, paired t = 3.24, df 7, p = 0.014, range 1–21 ng/ml, d’ = 1.15) and one-week twice-daily doses (mean change from baseline 4.58 ± 3.68 ng/ml standard deviation; paired t = 3.51, df 7, p < 0.001, range 2–13 ng/ml, d’ = 2.65). Betaine concentrations rose after both betaine and phosphatidylcholine supplementation. Conclusions: Betaine supplements did not substitute for phosphatidylcholine supplements, which raise serum choline concentrations both after a single dose and after repeated administration. However, serum betaine concentrations did rise after both betaine and phosphatidylcholine consumption and, therefore, betaine may be a stable indicator of choline intake. Keywords: Phosphatidylcholine, Choline, Betaine, Dimethylglycine, Pregnancyhttp://www.sciencedirect.com/science/article/pii/S2352385918300367 |
| spellingShingle | M. Camille Hoffman Ann Olincy Angelo D'Alessandro Julie A. Reisz Kirk C. Hansen Sharon K. Hunter Robert Freedman Randal G. Ross Effects of phosphatidylcholine and betaine supplements on women's serum choline Journal of Nutrition & Intermediary Metabolism |
| title | Effects of phosphatidylcholine and betaine supplements on women's serum choline |
| title_full | Effects of phosphatidylcholine and betaine supplements on women's serum choline |
| title_fullStr | Effects of phosphatidylcholine and betaine supplements on women's serum choline |
| title_full_unstemmed | Effects of phosphatidylcholine and betaine supplements on women's serum choline |
| title_short | Effects of phosphatidylcholine and betaine supplements on women's serum choline |
| title_sort | effects of phosphatidylcholine and betaine supplements on women s serum choline |
| url | http://www.sciencedirect.com/science/article/pii/S2352385918300367 |
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