Intestine-selective reduction of Gcg expression reveals the importance of the distal gut for GLP-1 secretion

Intestine-selective reduction of Gcg expression reveals the importance of the distal gut for GLP-1 secretion

Objective: Glucagon-like peptide-1 is a nutrient-sensitive hormone secreted from enteroendocrine L cells within the small and large bowel. Although GLP-1 levels rise rapidly in response to food ingestion, the greatest density of L cells is localized to the distal small bowel and colon. Here, we asse...

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Bibliographic Details
Main Authors: Brandon L. Panaro, Bernardo Yusta, Dianne Matthews, Jacqueline A. Koehler, Youngmi Song, Darleen A. Sandoval, Daniel J. Drucker
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Molecular Metabolism
Subjects:
Peptides
Intestine
Pancreas
Diabetes
Obesity
Metformin
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877820300648

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