Association of red cell distribution width with pulmonary arterial hypertension in patients with mixed connective tissue disease
Abstract Background Pulmonary arterial hypertension (PAH) is a severe complication of mixed connective tissue disease (MCTD) and contributes to increased morbidity and mortality. Still, the demographic characteristics and risk factors of PAH in MCTD remain poorly understood. This study explored risk...
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | BMC Pulmonary Medicine |
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| Online Access: | https://doi.org/10.1186/s12890-023-02597-z |
| _version_ | 1827724893567844352 |
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| author | Yansheng Jin Guanjun Guo Chun Wang Bo Jiang |
| author_facet | Yansheng Jin Guanjun Guo Chun Wang Bo Jiang |
| author_sort | Yansheng Jin |
| collection | DOAJ |
| description | Abstract Background Pulmonary arterial hypertension (PAH) is a severe complication of mixed connective tissue disease (MCTD) and contributes to increased morbidity and mortality. Still, the demographic characteristics and risk factors of PAH in MCTD remain poorly understood. This study explored risk factors for PAH development in MCTD. Methods Data from patients with MCTD and PAH hospitalized from May 2009 to December 2022 in a single center were collected and compared with patients with MCTD without PAH. The variables were analyzed by logistic regression to identify the factors associated with PAH in patients with MCTD. The receiver-operating characteristic (ROC) curve was used to assess the diagnostic value of the identified factors. Results Finally, 119 patients with MCTD were included; 46 had PAH. The mean age at PAH onset and diagnosis was 38.9 ± 13.4 and 39.9 ± 13.7 years, respectively. The median pulmonary arterial systolic pressure (PASP) was 67.0 mmHg. The median brain natriuretic peptide (BNP) level was 180.0 pg/ml at PAH diagnosis. Red cell distribution width (RDW) (OR: 2.128; 95% confidence interval: 1.497–3.026; P < 0.001) was associated with PAH in patients with MCTD. There was a positive correlation between RDW and PASP (r = 0.716, P < 0.001). At a cutoff of 15.2%, RDW had the best sensitivity (80.4%) and specificity (82.2%) for PAH. Conclusion RDW may serve as a sensitive index to predict PAH in patients with MCTD. |
| first_indexed | 2024-03-10T22:21:53Z |
| format | Article |
| id | doaj.art-10958d08c90f4a51a2462a8340186b59 |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-03-10T22:21:53Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-10958d08c90f4a51a2462a8340186b592023-11-19T12:14:58ZengBMCBMC Pulmonary Medicine1471-24662023-08-0123111010.1186/s12890-023-02597-zAssociation of red cell distribution width with pulmonary arterial hypertension in patients with mixed connective tissue diseaseYansheng Jin0Guanjun Guo1Chun Wang2Bo Jiang3Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolDepartment of Cardiology, Cardiac Function Room, The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolDepartment of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolDepartment of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolAbstract Background Pulmonary arterial hypertension (PAH) is a severe complication of mixed connective tissue disease (MCTD) and contributes to increased morbidity and mortality. Still, the demographic characteristics and risk factors of PAH in MCTD remain poorly understood. This study explored risk factors for PAH development in MCTD. Methods Data from patients with MCTD and PAH hospitalized from May 2009 to December 2022 in a single center were collected and compared with patients with MCTD without PAH. The variables were analyzed by logistic regression to identify the factors associated with PAH in patients with MCTD. The receiver-operating characteristic (ROC) curve was used to assess the diagnostic value of the identified factors. Results Finally, 119 patients with MCTD were included; 46 had PAH. The mean age at PAH onset and diagnosis was 38.9 ± 13.4 and 39.9 ± 13.7 years, respectively. The median pulmonary arterial systolic pressure (PASP) was 67.0 mmHg. The median brain natriuretic peptide (BNP) level was 180.0 pg/ml at PAH diagnosis. Red cell distribution width (RDW) (OR: 2.128; 95% confidence interval: 1.497–3.026; P < 0.001) was associated with PAH in patients with MCTD. There was a positive correlation between RDW and PASP (r = 0.716, P < 0.001). At a cutoff of 15.2%, RDW had the best sensitivity (80.4%) and specificity (82.2%) for PAH. Conclusion RDW may serve as a sensitive index to predict PAH in patients with MCTD.https://doi.org/10.1186/s12890-023-02597-zRed cell distribution widthPulmonary arterial hypertensionMixed connective tissue disease |
| spellingShingle | Yansheng Jin Guanjun Guo Chun Wang Bo Jiang Association of red cell distribution width with pulmonary arterial hypertension in patients with mixed connective tissue disease BMC Pulmonary Medicine Red cell distribution width Pulmonary arterial hypertension Mixed connective tissue disease |
| title | Association of red cell distribution width with pulmonary arterial hypertension in patients with mixed connective tissue disease |
| title_full | Association of red cell distribution width with pulmonary arterial hypertension in patients with mixed connective tissue disease |
| title_fullStr | Association of red cell distribution width with pulmonary arterial hypertension in patients with mixed connective tissue disease |
| title_full_unstemmed | Association of red cell distribution width with pulmonary arterial hypertension in patients with mixed connective tissue disease |
| title_short | Association of red cell distribution width with pulmonary arterial hypertension in patients with mixed connective tissue disease |
| title_sort | association of red cell distribution width with pulmonary arterial hypertension in patients with mixed connective tissue disease |
| topic | Red cell distribution width Pulmonary arterial hypertension Mixed connective tissue disease |
| url | https://doi.org/10.1186/s12890-023-02597-z |
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