Management of Brain Metastases from Human Epidermal Growth Factor Receptor 2 Positive (HER2+) Breast Cancer
In the past 5 years, the treatment options available to patients with HER2+ breast cancer brain metastasis (BCBM) have expanded. The longer survival of patients with HER2+ BCBM renders understanding the toxicities of local therapies even more important to consider. After reviewing the available lite...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/20/5136 |
| _version_ | 1797474483841269760 |
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| author | Tresa M. McGranahan Alipi V. Bonm Jennifer M. Specht Vyshak Venur Simon S. Lo |
| author_facet | Tresa M. McGranahan Alipi V. Bonm Jennifer M. Specht Vyshak Venur Simon S. Lo |
| author_sort | Tresa M. McGranahan |
| collection | DOAJ |
| description | In the past 5 years, the treatment options available to patients with HER2+ breast cancer brain metastasis (BCBM) have expanded. The longer survival of patients with HER2+ BCBM renders understanding the toxicities of local therapies even more important to consider. After reviewing the available literature for HER2 targeted systemic therapies as well as local therapies, we present a simplified algorithm for when to prioritize systemic therapies over local therapies in patients with HER2+ BCBM. |
| first_indexed | 2024-03-09T20:30:46Z |
| format | Article |
| id | doaj.art-109768f46d154531af88352af5bc507e |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T20:30:46Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-109768f46d154531af88352af5bc507e2023-11-23T23:22:35ZengMDPI AGCancers2072-66942022-10-011420513610.3390/cancers14205136Management of Brain Metastases from Human Epidermal Growth Factor Receptor 2 Positive (HER2+) Breast CancerTresa M. McGranahan0Alipi V. Bonm1Jennifer M. Specht2Vyshak Venur3Simon S. Lo4Department of Neurology, Alvord Brain Tumor Center, University of Washington School of Medicine, Seattle, WA 98195, USAVirginia Mason Franciscan Health, Seattle, WA 98101, USADivision of Medical Oncology, Fred Hutchinson Cancer Center/University of Washington, Seattle, WA 98109, USADepartment of Neurology, Alvord Brain Tumor Center, University of Washington School of Medicine, Seattle, WA 98195, USADepartment of Radiation Oncology, University of Washington School of Medicine, Seattle, WA 98195, USAIn the past 5 years, the treatment options available to patients with HER2+ breast cancer brain metastasis (BCBM) have expanded. The longer survival of patients with HER2+ BCBM renders understanding the toxicities of local therapies even more important to consider. After reviewing the available literature for HER2 targeted systemic therapies as well as local therapies, we present a simplified algorithm for when to prioritize systemic therapies over local therapies in patients with HER2+ BCBM.https://www.mdpi.com/2072-6694/14/20/5136breast cancerbrain metastasisHuman Epidermal growth factor Receptor 2 |
| spellingShingle | Tresa M. McGranahan Alipi V. Bonm Jennifer M. Specht Vyshak Venur Simon S. Lo Management of Brain Metastases from Human Epidermal Growth Factor Receptor 2 Positive (HER2+) Breast Cancer Cancers breast cancer brain metastasis Human Epidermal growth factor Receptor 2 |
| title | Management of Brain Metastases from Human Epidermal Growth Factor Receptor 2 Positive (HER2+) Breast Cancer |
| title_full | Management of Brain Metastases from Human Epidermal Growth Factor Receptor 2 Positive (HER2+) Breast Cancer |
| title_fullStr | Management of Brain Metastases from Human Epidermal Growth Factor Receptor 2 Positive (HER2+) Breast Cancer |
| title_full_unstemmed | Management of Brain Metastases from Human Epidermal Growth Factor Receptor 2 Positive (HER2+) Breast Cancer |
| title_short | Management of Brain Metastases from Human Epidermal Growth Factor Receptor 2 Positive (HER2+) Breast Cancer |
| title_sort | management of brain metastases from human epidermal growth factor receptor 2 positive her2 breast cancer |
| topic | breast cancer brain metastasis Human Epidermal growth factor Receptor 2 |
| url | https://www.mdpi.com/2072-6694/14/20/5136 |
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