Wilms or non-Wilms tumors? Imaging features of renal tumors in pediatrics
Introduction: Identifying the imaging features of renal tumors in pediatric population allows reaching more accurate diagnoses and implementing more appropriate treatments. Objective: To describe the imaging findings of renal tumors in children and to assess the association between imaging findings...
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| Format: | Article |
| Language: | English |
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Universidad Nacional de Colombia
2021-04-01
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| Series: | Revista de la Facultad de Medicina |
| Subjects: | |
| Online Access: | https://revistas.unal.edu.co/index.php/revfacmed/article/view/88323 |
| _version_ | 1827945305852608512 |
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| author | Mónica Rocío Royero-Arias Luis Carlos Salazar-Díaz Luz Ángela Moreno-Gómez |
| author_facet | Mónica Rocío Royero-Arias Luis Carlos Salazar-Díaz Luz Ángela Moreno-Gómez |
| author_sort | Mónica Rocío Royero-Arias |
| collection | DOAJ |
| description | Introduction: Identifying the imaging features of renal tumors in pediatric population allows reaching more accurate diagnoses and implementing more appropriate treatments.
Objective: To describe the imaging findings of renal tumors in children and to assess the association between imaging findings and histological diagnosis of Wilms tumors versus Non-Wilms tumors, and between imaging features and intraoperative rupture of Wilms tumors, as well as the level of agreement between radiological and histological diagnosis (Wilms vs. Non-Wilms tumor).
Materials and methods: Cross-sectional study conducted in 47 children with a pathological diagnosis of kidney tumor and treated between 2012 and 2018 in a pediatric hospital in Bogotá D.C., Colombia. The patients’ medical records, as well as their ultrasound, tomography and magnetic resonance studies were reviewed. Two univariate logistic regression analyses were performed to assess the association between imaging findings and histopathological diagnosis and between imaging features and intraoperative rupture of Wilms tumors, calculating the respective Odds Ratio (OR) with a 95% confidence interval. In addition, the level of agreement between radiological and histological diagnosis was determined using the Cohen’s kappa coefficient.
Results: A significant association was found between histological diagnosis of Wilms tumor and the presence of necrosis, tumor enhancement, pseudocapsule, rupture signs, tumor volume and tumor size (OR: 21.6, 15.17, 14.57, 8.21, 7.93, and 4.37, respectively; p<0.05). An association between having Wilms tumors and a lower frequency of metastases was also found (OR: 0.19; p<0.05). The kappa coefficient between radiological diagnosis of Wilms/non-Wilms tumors and histological diagnosis was 0.78 (CI95%: 0.59-0.96; p<0.05). Additionally, Wilms tumors volume was significantly associated with the occurrence of rupture (OR: 3.08; p<0.05).
Conclusions: There are imaging findings such as necrosis, tumor enhancement and tumor volume that can help predict the histological diagnosis of Wilms tumors, as well as perioperative rupture. In addition, a moderate to very good concordance between radiological diagnosis of Wilms/non-Wilms tumors and histological findings was found.
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| first_indexed | 2024-03-13T10:42:47Z |
| format | Article |
| id | doaj.art-1097a31ee8414589a03b2e1b16f391d5 |
| institution | Directory Open Access Journal |
| issn | 0120-0011 2357-3848 |
| language | English |
| last_indexed | 2024-03-13T10:42:47Z |
| publishDate | 2021-04-01 |
| publisher | Universidad Nacional de Colombia |
| record_format | Article |
| series | Revista de la Facultad de Medicina |
| spelling | doaj.art-1097a31ee8414589a03b2e1b16f391d52023-05-17T22:03:21ZengUniversidad Nacional de ColombiaRevista de la Facultad de Medicina0120-00112357-38482021-04-0170110.15446/revfacmed.v70n1.88323Wilms or non-Wilms tumors? Imaging features of renal tumors in pediatricsMónica Rocío Royero-Arias0Luis Carlos Salazar-Díaz1Luz Ángela Moreno-Gómez2Universidad Nacional de Colombia - Bogotá Campus - Faculty of Medicine - Department of Diagnostic Imaging - Bogotá D.C. - Colombia.Universidad Nacional de Colombia - Bogotá Campus - Faculty of Medicine - Department of Diagnostic Imaging - Bogotá D.C. - Colombia.Universidad Nacional de Colombia - Bogotá Campus - Faculty of Medicine - Department of Diagnostic Imaging - Bogotá D.C. - Colombia. | Fundación Hospital Pediátrico La Misericordia - Bogotá - D.C. - Colombia.Introduction: Identifying the imaging features of renal tumors in pediatric population allows reaching more accurate diagnoses and implementing more appropriate treatments. Objective: To describe the imaging findings of renal tumors in children and to assess the association between imaging findings and histological diagnosis of Wilms tumors versus Non-Wilms tumors, and between imaging features and intraoperative rupture of Wilms tumors, as well as the level of agreement between radiological and histological diagnosis (Wilms vs. Non-Wilms tumor). Materials and methods: Cross-sectional study conducted in 47 children with a pathological diagnosis of kidney tumor and treated between 2012 and 2018 in a pediatric hospital in Bogotá D.C., Colombia. The patients’ medical records, as well as their ultrasound, tomography and magnetic resonance studies were reviewed. Two univariate logistic regression analyses were performed to assess the association between imaging findings and histopathological diagnosis and between imaging features and intraoperative rupture of Wilms tumors, calculating the respective Odds Ratio (OR) with a 95% confidence interval. In addition, the level of agreement between radiological and histological diagnosis was determined using the Cohen’s kappa coefficient. Results: A significant association was found between histological diagnosis of Wilms tumor and the presence of necrosis, tumor enhancement, pseudocapsule, rupture signs, tumor volume and tumor size (OR: 21.6, 15.17, 14.57, 8.21, 7.93, and 4.37, respectively; p<0.05). An association between having Wilms tumors and a lower frequency of metastases was also found (OR: 0.19; p<0.05). The kappa coefficient between radiological diagnosis of Wilms/non-Wilms tumors and histological diagnosis was 0.78 (CI95%: 0.59-0.96; p<0.05). Additionally, Wilms tumors volume was significantly associated with the occurrence of rupture (OR: 3.08; p<0.05). Conclusions: There are imaging findings such as necrosis, tumor enhancement and tumor volume that can help predict the histological diagnosis of Wilms tumors, as well as perioperative rupture. In addition, a moderate to very good concordance between radiological diagnosis of Wilms/non-Wilms tumors and histological findings was found. https://revistas.unal.edu.co/index.php/revfacmed/article/view/88323Renal NeoplasmsWilms TumorDiagnostic ImagingPediatrics |
| spellingShingle | Mónica Rocío Royero-Arias Luis Carlos Salazar-Díaz Luz Ángela Moreno-Gómez Wilms or non-Wilms tumors? Imaging features of renal tumors in pediatrics Revista de la Facultad de Medicina Renal Neoplasms Wilms Tumor Diagnostic Imaging Pediatrics |
| title | Wilms or non-Wilms tumors? Imaging features of renal tumors in pediatrics |
| title_full | Wilms or non-Wilms tumors? Imaging features of renal tumors in pediatrics |
| title_fullStr | Wilms or non-Wilms tumors? Imaging features of renal tumors in pediatrics |
| title_full_unstemmed | Wilms or non-Wilms tumors? Imaging features of renal tumors in pediatrics |
| title_short | Wilms or non-Wilms tumors? Imaging features of renal tumors in pediatrics |
| title_sort | wilms or non wilms tumors imaging features of renal tumors in pediatrics |
| topic | Renal Neoplasms Wilms Tumor Diagnostic Imaging Pediatrics |
| url | https://revistas.unal.edu.co/index.php/revfacmed/article/view/88323 |
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