The active site of the SGNH hydrolase-like fold proteins: Nucleophile–oxyanion (Nuc-Oxy) and Acid–Base zones

The active site of the SGNH hydrolase-like fold proteins: Nucleophile–oxyanion (Nuc-Oxy) and Acid–Base zones

SGNH hydrolase-like fold proteins are serine proteases with the default Asp-His-Ser catalytic triad. Here, we show that these proteins share two unique conserved structural organizations around the active site: (1) the Nuc-Oxy Zone around the catalytic nucleophile and the oxyanion hole, and (2) the...

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Bibliographic Details
Main Authors: Konstantin Denessiouk, Alexander I. Denesyuk, Sergei E. Permyakov, Eugene A. Permyakov, Mark S. Johnson, Vladimir N. Uversky
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Current Research in Structural Biology
Subjects:
SGNH-Hydrolases
Catalytic triad
Oxyanion hole
Nuc–Oxy and Acid–Base zones
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Online Access:http://www.sciencedirect.com/science/article/pii/S2665928X23000296

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