Perspective: Mitochondria-ER Contacts in Metabolic Cellular Stress Assessed by Microscopy

Perspective: Mitochondria-ER Contacts in Metabolic Cellular Stress Assessed by Microscopy

The interplay of mitochondria with the endoplasmic reticulum and their connections, called mitochondria-ER contacts (MERCs) or mitochondria-associated ER membranes (MAMs), are crucial hubs in cellular stress. These sites are essential for the passage of calcium ions, reactive oxygen species delivery...

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Bibliographic Details
Main Authors: Alessandra Stacchiotti, Gaia Favero, Antonio Lavazza, Raquel Garcia-Gomez, Maria Monsalve, Rita Rezzani
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Cells
Subjects:
mitochondria
endoplasmic reticulum
MERCs
MAMs
obesity
neurodegenerative diseases
microscopy
Online Access:https://www.mdpi.com/2073-4409/8/1/5
Description
Summary:The interplay of mitochondria with the endoplasmic reticulum and their connections, called mitochondria-ER contacts (MERCs) or mitochondria-associated ER membranes (MAMs), are crucial hubs in cellular stress. These sites are essential for the passage of calcium ions, reactive oxygen species delivery, the sorting of lipids in whole-body metabolism. In this perspective article, we focus on microscopic evidences of the pivotal role of MERCs/MAMs and their changes in metabolic diseases, like obesity, diabetes, and neurodegeneration.
ISSN:2073-4409

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