Perspective: Mitochondria-ER Contacts in Metabolic Cellular Stress Assessed by Microscopy
The interplay of mitochondria with the endoplasmic reticulum and their connections, called mitochondria-ER contacts (MERCs) or mitochondria-associated ER membranes (MAMs), are crucial hubs in cellular stress. These sites are essential for the passage of calcium ions, reactive oxygen species delivery...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-12-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/8/1/5 |
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| author | Alessandra Stacchiotti Gaia Favero Antonio Lavazza Raquel Garcia-Gomez Maria Monsalve Rita Rezzani |
| author_facet | Alessandra Stacchiotti Gaia Favero Antonio Lavazza Raquel Garcia-Gomez Maria Monsalve Rita Rezzani |
| author_sort | Alessandra Stacchiotti |
| collection | DOAJ |
| description | The interplay of mitochondria with the endoplasmic reticulum and their connections, called mitochondria-ER contacts (MERCs) or mitochondria-associated ER membranes (MAMs), are crucial hubs in cellular stress. These sites are essential for the passage of calcium ions, reactive oxygen species delivery, the sorting of lipids in whole-body metabolism. In this perspective article, we focus on microscopic evidences of the pivotal role of MERCs/MAMs and their changes in metabolic diseases, like obesity, diabetes, and neurodegeneration. |
| first_indexed | 2024-03-12T08:04:32Z |
| format | Article |
| id | doaj.art-1099690111914f19add29a5b5020ea3d |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T08:04:32Z |
| publishDate | 2018-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-1099690111914f19add29a5b5020ea3d2023-09-02T19:37:04ZengMDPI AGCells2073-44092018-12-0181510.3390/cells8010005cells8010005Perspective: Mitochondria-ER Contacts in Metabolic Cellular Stress Assessed by MicroscopyAlessandra Stacchiotti0Gaia Favero1Antonio Lavazza2Raquel Garcia-Gomez3Maria Monsalve4Rita Rezzani5Anatomy and Physiopathology Division, Department of Clinical and Experimental Sciences, University of Brescia, Viale Europa 11, 25123 Brescia, ItalyAnatomy and Physiopathology Division, Department of Clinical and Experimental Sciences, University of Brescia, Viale Europa 11, 25123 Brescia, ItalyIstituto Zooprofilattico Sperimentale della Lombardia ed Emilia Romagna-IZSLER, 25124 Brescia, ItalyInstituto de Investigaciones Biomedicas “Alberto Sols” (CSIC-UAM), 28029 Madrid, SpainInstituto de Investigaciones Biomedicas “Alberto Sols” (CSIC-UAM), 28029 Madrid, SpainAnatomy and Physiopathology Division, Department of Clinical and Experimental Sciences, University of Brescia, Viale Europa 11, 25123 Brescia, ItalyThe interplay of mitochondria with the endoplasmic reticulum and their connections, called mitochondria-ER contacts (MERCs) or mitochondria-associated ER membranes (MAMs), are crucial hubs in cellular stress. These sites are essential for the passage of calcium ions, reactive oxygen species delivery, the sorting of lipids in whole-body metabolism. In this perspective article, we focus on microscopic evidences of the pivotal role of MERCs/MAMs and their changes in metabolic diseases, like obesity, diabetes, and neurodegeneration.https://www.mdpi.com/2073-4409/8/1/5mitochondriaendoplasmic reticulumMERCsMAMsobesityneurodegenerative diseasesmicroscopy |
| spellingShingle | Alessandra Stacchiotti Gaia Favero Antonio Lavazza Raquel Garcia-Gomez Maria Monsalve Rita Rezzani Perspective: Mitochondria-ER Contacts in Metabolic Cellular Stress Assessed by Microscopy Cells mitochondria endoplasmic reticulum MERCs MAMs obesity neurodegenerative diseases microscopy |
| title | Perspective: Mitochondria-ER Contacts in Metabolic Cellular Stress Assessed by Microscopy |
| title_full | Perspective: Mitochondria-ER Contacts in Metabolic Cellular Stress Assessed by Microscopy |
| title_fullStr | Perspective: Mitochondria-ER Contacts in Metabolic Cellular Stress Assessed by Microscopy |
| title_full_unstemmed | Perspective: Mitochondria-ER Contacts in Metabolic Cellular Stress Assessed by Microscopy |
| title_short | Perspective: Mitochondria-ER Contacts in Metabolic Cellular Stress Assessed by Microscopy |
| title_sort | perspective mitochondria er contacts in metabolic cellular stress assessed by microscopy |
| topic | mitochondria endoplasmic reticulum MERCs MAMs obesity neurodegenerative diseases microscopy |
| url | https://www.mdpi.com/2073-4409/8/1/5 |
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