The Activation of Protamine 1 Using Epigenome Editing Decreases the Proliferation of Tumorigenic Cells

The Activation of Protamine 1 Using Epigenome Editing Decreases the Proliferation of Tumorigenic Cells

DNA methyltransferases (DNMT) and histone deacetylases (HDAC) inhibitors are used as cancer epigenome drugs. However, these epigenetic drugs lack targeting specificity and could risk inducing genome instability and the expression of oncogenes. Therefore, there is a need to develop new therapeutic st...

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Bibliographic Details
Main Authors: Hadjer Namous, Camila Urbano Braz, Yiding Wang, Hasan Khatib
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Genome Editing
Subjects:
epigenome editing
PRM1
activation
proliferation
tumorigenesis
cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fgeed.2022.844904/full

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https://www.frontiersin.org/articles/10.3389/fgeed.2022.844904/full

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