Discriminating early-stage diabetic retinopathy with subjective and objective perimetry
IntroductionTo prevent progression of early-stage diabetic retinopathy, we need functional tests that can distinguish multiple levels of neural damage before classical vasculopathy. To that end, we compared multifocal pupillographic objective perimetry (mfPOP), and two types of subjective automated...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-01-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1333826/full |
| _version_ | 1827387570385846272 |
|---|---|
| author | Faran Sabeti Faran Sabeti Joshua P. van Kleef Rakesh M. Iyer Corinne F. Carle Christopher J. Nolan Christopher J. Nolan Rong Hui Chia Ted Maddess |
| author_facet | Faran Sabeti Faran Sabeti Joshua P. van Kleef Rakesh M. Iyer Corinne F. Carle Christopher J. Nolan Christopher J. Nolan Rong Hui Chia Ted Maddess |
| author_sort | Faran Sabeti |
| collection | DOAJ |
| description | IntroductionTo prevent progression of early-stage diabetic retinopathy, we need functional tests that can distinguish multiple levels of neural damage before classical vasculopathy. To that end, we compared multifocal pupillographic objective perimetry (mfPOP), and two types of subjective automated perimetry (SAP), in persons with type 2 diabetes (PwT2D) with either no retinopathy (noDR) or mild to-moderate non-proliferative retinopathy (mmDR).MethodsBoth eyes were assessed by two mfPOP test methods that present stimuli within either the central ±15° (OFA15) or ±30° (OFA30), each producing per-region sensitivities and response delays. The SAP tests were 24-2 Short Wavelength Automated Perimetry and 24-2 Matrix perimetry.ResultsFive of eight mfPOP global indices were significantly different between noDR and mmDR eyes, but none of the equivalent measures differed for SAP. Per-region mfPOP identified significant hypersensitivity and longer delays in the peripheral visual field, verifying earlier findings. Diagnostic power for discrimination of noDR vs. mmDR, and normal controls vs. PwT2D, was much higher for mfPOP than SAP. The mfPOP per-region delays provided the best discrimination. The presence of localized rather than global changes in delay ruled out iris neuropathy as a major factor.DiscussionmfPOP response delays may provide new surrogate endpoints for studies of interventions for early-stage diabetic eye damage. |
| first_indexed | 2024-03-08T16:05:08Z |
| format | Article |
| id | doaj.art-109c80a9c8d84000a5cd5211b0194a9c |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-08T16:05:08Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-109c80a9c8d84000a5cd5211b0194a9c2024-01-08T06:20:00ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-01-011410.3389/fendo.2023.13338261333826Discriminating early-stage diabetic retinopathy with subjective and objective perimetryFaran Sabeti0Faran Sabeti1Joshua P. van Kleef2Rakesh M. Iyer3Corinne F. Carle4Christopher J. Nolan5Christopher J. Nolan6Rong Hui Chia7Ted Maddess8Eccles Institute for Neuroscience, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, AustraliaDiscipline of Optometry, Faculty of Health, University of Canberra, Canberra, ACT, AustraliaEccles Institute for Neuroscience, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, AustraliaDepartment of Endocrinology, The Canberra Hospital, Garran, ACT, AustraliaEccles Institute for Neuroscience, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, AustraliaDepartment of Endocrinology, The Canberra Hospital, Garran, ACT, AustraliaSchool of Medicine and Psychology, The Australian National University, Canberra, ACT, AustraliaSchool of Medicine, University of Western Australia, Crawley, WA, AustraliaEccles Institute for Neuroscience, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, AustraliaIntroductionTo prevent progression of early-stage diabetic retinopathy, we need functional tests that can distinguish multiple levels of neural damage before classical vasculopathy. To that end, we compared multifocal pupillographic objective perimetry (mfPOP), and two types of subjective automated perimetry (SAP), in persons with type 2 diabetes (PwT2D) with either no retinopathy (noDR) or mild to-moderate non-proliferative retinopathy (mmDR).MethodsBoth eyes were assessed by two mfPOP test methods that present stimuli within either the central ±15° (OFA15) or ±30° (OFA30), each producing per-region sensitivities and response delays. The SAP tests were 24-2 Short Wavelength Automated Perimetry and 24-2 Matrix perimetry.ResultsFive of eight mfPOP global indices were significantly different between noDR and mmDR eyes, but none of the equivalent measures differed for SAP. Per-region mfPOP identified significant hypersensitivity and longer delays in the peripheral visual field, verifying earlier findings. Diagnostic power for discrimination of noDR vs. mmDR, and normal controls vs. PwT2D, was much higher for mfPOP than SAP. The mfPOP per-region delays provided the best discrimination. The presence of localized rather than global changes in delay ruled out iris neuropathy as a major factor.DiscussionmfPOP response delays may provide new surrogate endpoints for studies of interventions for early-stage diabetic eye damage.https://www.frontiersin.org/articles/10.3389/fendo.2023.1333826/fullmultifocaltype 2 diabetesdiabetic retinopathyobjective perimetrysubjective perimetrymultifocal methods |
| spellingShingle | Faran Sabeti Faran Sabeti Joshua P. van Kleef Rakesh M. Iyer Corinne F. Carle Christopher J. Nolan Christopher J. Nolan Rong Hui Chia Ted Maddess Discriminating early-stage diabetic retinopathy with subjective and objective perimetry Frontiers in Endocrinology multifocal type 2 diabetes diabetic retinopathy objective perimetry subjective perimetry multifocal methods |
| title | Discriminating early-stage diabetic retinopathy with subjective and objective perimetry |
| title_full | Discriminating early-stage diabetic retinopathy with subjective and objective perimetry |
| title_fullStr | Discriminating early-stage diabetic retinopathy with subjective and objective perimetry |
| title_full_unstemmed | Discriminating early-stage diabetic retinopathy with subjective and objective perimetry |
| title_short | Discriminating early-stage diabetic retinopathy with subjective and objective perimetry |
| title_sort | discriminating early stage diabetic retinopathy with subjective and objective perimetry |
| topic | multifocal type 2 diabetes diabetic retinopathy objective perimetry subjective perimetry multifocal methods |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1333826/full |
| work_keys_str_mv | AT faransabeti discriminatingearlystagediabeticretinopathywithsubjectiveandobjectiveperimetry AT faransabeti discriminatingearlystagediabeticretinopathywithsubjectiveandobjectiveperimetry AT joshuapvankleef discriminatingearlystagediabeticretinopathywithsubjectiveandobjectiveperimetry AT rakeshmiyer discriminatingearlystagediabeticretinopathywithsubjectiveandobjectiveperimetry AT corinnefcarle discriminatingearlystagediabeticretinopathywithsubjectiveandobjectiveperimetry AT christopherjnolan discriminatingearlystagediabeticretinopathywithsubjectiveandobjectiveperimetry AT christopherjnolan discriminatingearlystagediabeticretinopathywithsubjectiveandobjectiveperimetry AT ronghuichia discriminatingearlystagediabeticretinopathywithsubjectiveandobjectiveperimetry AT tedmaddess discriminatingearlystagediabeticretinopathywithsubjectiveandobjectiveperimetry |