Validation of the European Cross-Cultural Neuropsychological Test Battery (CNTB) for the assessment of mild cognitive impairment due to Alzheimer's disease and Parkinson's disease
BackgroundThe Cross-Cultural Neuropsychological Test Battery (CNTB) is a novel test battery specifically designed to reduce the impact of multiculturality in cognitive assessment.ObjectiveWe aimed to validate the CNTB in Spaniards in patients with Alzheimer's disease (AD), including patients at...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1134111/full |
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| author | Alfonso Delgado-Álvarez Alfonso Delgado-Álvarez Thomas Rune Nielsen Cristina Delgado-Alonso María Valles-Salgado Juan I. López-Carbonero Rocío García-Ramos María José Gil-Moreno María Díez-Cirarda Jorge Matías-Guiu Jordi A. Matias-Guiu |
| author_facet | Alfonso Delgado-Álvarez Alfonso Delgado-Álvarez Thomas Rune Nielsen Cristina Delgado-Alonso María Valles-Salgado Juan I. López-Carbonero Rocío García-Ramos María José Gil-Moreno María Díez-Cirarda Jorge Matías-Guiu Jordi A. Matias-Guiu |
| author_sort | Alfonso Delgado-Álvarez |
| collection | DOAJ |
| description | BackgroundThe Cross-Cultural Neuropsychological Test Battery (CNTB) is a novel test battery specifically designed to reduce the impact of multiculturality in cognitive assessment.ObjectiveWe aimed to validate the CNTB in Spaniards in patients with Alzheimer's disease (AD), including patients at mild cognitive impairment (MCI) and mild dementia stages, and Parkinson's disease with MCI (PD-MCI).MethodsThirty patients with AD-MCI, 30 with AD-dementia (AD-D), and 30 with PD-MCI were recruited. Each clinical group was compared against a healthy control group (HC) with no differences in sex, age, or years of education. Intergroup comparisons, ROC analysis, and cut-off scores were calculated.ResultsAD-MCI scored lower than HC in those subtests associated with episodic memory and verbal fluency. AD-D also showed lower scores in executive functions and visuospatial tests. Effect sizes for all the subtests were large. PD-MCI showed lower performance than HC in memory and executive functions, particularly on error scores, with large effect sizes. Comparing AD-MCI and PD-MCI, AD-MCI had lower memory scores, while PD-MCI showed the worst performance in executive functions. CNTB showed appropriate convergent validity with standardized neuropsychological tests measuring the same cognitive domains. We obtained similar cut-off scores to previous studies performed in other populations.ConclusionsThe CNTB showed appropriate diagnostic properties in AD and PD, including those stages with mild cognitive impairment. This supports the utility of the CNTB for the early detection of cognitive impairment in AD and PD. |
| first_indexed | 2024-04-09T14:17:00Z |
| format | Article |
| id | doaj.art-109da89a7bbb48618babcde8b801ddfa |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-09T14:17:00Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-109da89a7bbb48618babcde8b801ddfa2023-05-05T05:53:34ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652023-05-011510.3389/fnagi.2023.11341111134111Validation of the European Cross-Cultural Neuropsychological Test Battery (CNTB) for the assessment of mild cognitive impairment due to Alzheimer's disease and Parkinson's diseaseAlfonso Delgado-Álvarez0Alfonso Delgado-Álvarez1Thomas Rune Nielsen2Cristina Delgado-Alonso3María Valles-Salgado4Juan I. López-Carbonero5Rocío García-Ramos6María José Gil-Moreno7María Díez-Cirarda8Jorge Matías-Guiu9Jordi A. Matias-Guiu10Department of Neurology, Hospital Clinico San Carlos, San Carlos Institute for Health Research (IdISSC), Universidad Complutense, Madrid, SpainFaculty of Psychology, Universidad Autónoma de Madrid, Madrid, SpainDepartment of Neurology, Danish Dementia Research Centre, University of Copenhagen-Rigshospitalet, Copenhagen, DenmarkDepartment of Neurology, Hospital Clinico San Carlos, San Carlos Institute for Health Research (IdISSC), Universidad Complutense, Madrid, SpainDepartment of Neurology, Hospital Clinico San Carlos, San Carlos Institute for Health Research (IdISSC), Universidad Complutense, Madrid, SpainDepartment of Neurology, Hospital Clinico San Carlos, San Carlos Institute for Health Research (IdISSC), Universidad Complutense, Madrid, SpainDepartment of Neurology, Hospital Clinico San Carlos, San Carlos Institute for Health Research (IdISSC), Universidad Complutense, Madrid, SpainDepartment of Neurology, Hospital Clinico San Carlos, San Carlos Institute for Health Research (IdISSC), Universidad Complutense, Madrid, SpainDepartment of Neurology, Hospital Clinico San Carlos, San Carlos Institute for Health Research (IdISSC), Universidad Complutense, Madrid, SpainDepartment of Neurology, Hospital Clinico San Carlos, San Carlos Institute for Health Research (IdISSC), Universidad Complutense, Madrid, SpainDepartment of Neurology, Hospital Clinico San Carlos, San Carlos Institute for Health Research (IdISSC), Universidad Complutense, Madrid, SpainBackgroundThe Cross-Cultural Neuropsychological Test Battery (CNTB) is a novel test battery specifically designed to reduce the impact of multiculturality in cognitive assessment.ObjectiveWe aimed to validate the CNTB in Spaniards in patients with Alzheimer's disease (AD), including patients at mild cognitive impairment (MCI) and mild dementia stages, and Parkinson's disease with MCI (PD-MCI).MethodsThirty patients with AD-MCI, 30 with AD-dementia (AD-D), and 30 with PD-MCI were recruited. Each clinical group was compared against a healthy control group (HC) with no differences in sex, age, or years of education. Intergroup comparisons, ROC analysis, and cut-off scores were calculated.ResultsAD-MCI scored lower than HC in those subtests associated with episodic memory and verbal fluency. AD-D also showed lower scores in executive functions and visuospatial tests. Effect sizes for all the subtests were large. PD-MCI showed lower performance than HC in memory and executive functions, particularly on error scores, with large effect sizes. Comparing AD-MCI and PD-MCI, AD-MCI had lower memory scores, while PD-MCI showed the worst performance in executive functions. CNTB showed appropriate convergent validity with standardized neuropsychological tests measuring the same cognitive domains. We obtained similar cut-off scores to previous studies performed in other populations.ConclusionsThe CNTB showed appropriate diagnostic properties in AD and PD, including those stages with mild cognitive impairment. This supports the utility of the CNTB for the early detection of cognitive impairment in AD and PD.https://www.frontiersin.org/articles/10.3389/fnagi.2023.1134111/fullAlzheimer's diseasecognitive assessmentcross-cultural neuropsychologymild cognitive impairmentParkinson's disease |
| spellingShingle | Alfonso Delgado-Álvarez Alfonso Delgado-Álvarez Thomas Rune Nielsen Cristina Delgado-Alonso María Valles-Salgado Juan I. López-Carbonero Rocío García-Ramos María José Gil-Moreno María Díez-Cirarda Jorge Matías-Guiu Jordi A. Matias-Guiu Validation of the European Cross-Cultural Neuropsychological Test Battery (CNTB) for the assessment of mild cognitive impairment due to Alzheimer's disease and Parkinson's disease Frontiers in Aging Neuroscience Alzheimer's disease cognitive assessment cross-cultural neuropsychology mild cognitive impairment Parkinson's disease |
| title | Validation of the European Cross-Cultural Neuropsychological Test Battery (CNTB) for the assessment of mild cognitive impairment due to Alzheimer's disease and Parkinson's disease |
| title_full | Validation of the European Cross-Cultural Neuropsychological Test Battery (CNTB) for the assessment of mild cognitive impairment due to Alzheimer's disease and Parkinson's disease |
| title_fullStr | Validation of the European Cross-Cultural Neuropsychological Test Battery (CNTB) for the assessment of mild cognitive impairment due to Alzheimer's disease and Parkinson's disease |
| title_full_unstemmed | Validation of the European Cross-Cultural Neuropsychological Test Battery (CNTB) for the assessment of mild cognitive impairment due to Alzheimer's disease and Parkinson's disease |
| title_short | Validation of the European Cross-Cultural Neuropsychological Test Battery (CNTB) for the assessment of mild cognitive impairment due to Alzheimer's disease and Parkinson's disease |
| title_sort | validation of the european cross cultural neuropsychological test battery cntb for the assessment of mild cognitive impairment due to alzheimer s disease and parkinson s disease |
| topic | Alzheimer's disease cognitive assessment cross-cultural neuropsychology mild cognitive impairment Parkinson's disease |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1134111/full |
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