Nanodrug Delivery Systems for the Treatment of Ovarian Cancer
Despite advances achieved in medicine, chemotherapeutics still has detrimental side effects with ovarian cancer (OC), accounting for numerous deaths among females. The provision of safe, early detection and active treatment of OC remains a challenge, in spite of improvements in new antineoplastic di...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-01-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/12/1/213 |
| _version_ | 1797762700968722432 |
|---|---|
| author | Jonathan M. Pantshwa Pierre P. D. Kondiah Yahya E. Choonara Thashree Marimuthu Viness Pillay |
| author_facet | Jonathan M. Pantshwa Pierre P. D. Kondiah Yahya E. Choonara Thashree Marimuthu Viness Pillay |
| author_sort | Jonathan M. Pantshwa |
| collection | DOAJ |
| description | Despite advances achieved in medicine, chemotherapeutics still has detrimental side effects with ovarian cancer (OC), accounting for numerous deaths among females. The provision of safe, early detection and active treatment of OC remains a challenge, in spite of improvements in new antineoplastic discovery. Nanosystems have shown remarkable progress with impact in diagnosis and chemotherapy of various cancers, due to their ideal size; improved drug encapsulation within its interior core; potential to minimize drug degradation; improve in vivo drug release kinetics; and prolong blood circulation times. However, nanodrug delivery systems have few limitations regarding its accuracy of tumour targeting and the ability to provide sustained drug release. Hence, a cogent and strategic approach has focused on nanosystem functionalization with antibody-based ligands to selectively enhance cellular uptake of antineoplastics. Antibody functionalized nanosystems are (advanced) synthetic candidates, with a broad range of efficiency in specific tumour targeting, whilst leaving normal cells unaffected. This article comprehensively reviews the present status of nanosystems, with particular emphasis on nanomicelles for molecular diagnosis and treatment of OC. In addition, biomarkers of nanosystems provide important prospects as chemotherapeutic strategies to upsurge the survival rate of patients with OC. |
| first_indexed | 2024-03-12T19:31:12Z |
| format | Article |
| id | doaj.art-109ecd48b9a94f119058e849efda315b |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T19:31:12Z |
| publishDate | 2020-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-109ecd48b9a94f119058e849efda315b2023-08-02T04:27:07ZengMDPI AGCancers2072-66942020-01-0112121310.3390/cancers12010213cancers12010213Nanodrug Delivery Systems for the Treatment of Ovarian CancerJonathan M. Pantshwa0Pierre P. D. Kondiah1Yahya E. Choonara2Thashree Marimuthu3Viness Pillay4Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown 2193, South AfricaWits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown 2193, South AfricaWits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown 2193, South AfricaWits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown 2193, South AfricaWits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown 2193, South AfricaDespite advances achieved in medicine, chemotherapeutics still has detrimental side effects with ovarian cancer (OC), accounting for numerous deaths among females. The provision of safe, early detection and active treatment of OC remains a challenge, in spite of improvements in new antineoplastic discovery. Nanosystems have shown remarkable progress with impact in diagnosis and chemotherapy of various cancers, due to their ideal size; improved drug encapsulation within its interior core; potential to minimize drug degradation; improve in vivo drug release kinetics; and prolong blood circulation times. However, nanodrug delivery systems have few limitations regarding its accuracy of tumour targeting and the ability to provide sustained drug release. Hence, a cogent and strategic approach has focused on nanosystem functionalization with antibody-based ligands to selectively enhance cellular uptake of antineoplastics. Antibody functionalized nanosystems are (advanced) synthetic candidates, with a broad range of efficiency in specific tumour targeting, whilst leaving normal cells unaffected. This article comprehensively reviews the present status of nanosystems, with particular emphasis on nanomicelles for molecular diagnosis and treatment of OC. In addition, biomarkers of nanosystems provide important prospects as chemotherapeutic strategies to upsurge the survival rate of patients with OC.https://www.mdpi.com/2072-6694/12/1/213nanosystemsdrug deliverynanomicellesovarian cancertumour targetingchemotherapeutics |
| spellingShingle | Jonathan M. Pantshwa Pierre P. D. Kondiah Yahya E. Choonara Thashree Marimuthu Viness Pillay Nanodrug Delivery Systems for the Treatment of Ovarian Cancer Cancers nanosystems drug delivery nanomicelles ovarian cancer tumour targeting chemotherapeutics |
| title | Nanodrug Delivery Systems for the Treatment of Ovarian Cancer |
| title_full | Nanodrug Delivery Systems for the Treatment of Ovarian Cancer |
| title_fullStr | Nanodrug Delivery Systems for the Treatment of Ovarian Cancer |
| title_full_unstemmed | Nanodrug Delivery Systems for the Treatment of Ovarian Cancer |
| title_short | Nanodrug Delivery Systems for the Treatment of Ovarian Cancer |
| title_sort | nanodrug delivery systems for the treatment of ovarian cancer |
| topic | nanosystems drug delivery nanomicelles ovarian cancer tumour targeting chemotherapeutics |
| url | https://www.mdpi.com/2072-6694/12/1/213 |
| work_keys_str_mv | AT jonathanmpantshwa nanodrugdeliverysystemsforthetreatmentofovariancancer AT pierrepdkondiah nanodrugdeliverysystemsforthetreatmentofovariancancer AT yahyaechoonara nanodrugdeliverysystemsforthetreatmentofovariancancer AT thashreemarimuthu nanodrugdeliverysystemsforthetreatmentofovariancancer AT vinesspillay nanodrugdeliverysystemsforthetreatmentofovariancancer |