T-cell exhaustion and stemness in antitumor immunity: Characteristics, mechanisms, and implications
T cells play a crucial role in the regulation of immune response and are integral to the efficacy of cancer immunotherapy. Because immunotherapy has emerged as a promising treatment for cancer, increasing attention has been focused on the differentiation and function of T cells in immune response. I...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1104771/full |
| _version_ | 1797902933791080448 |
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| author | Xiaoxia Chi Shahang Luo Peng Ye Wei-Lun Hwang Wei-Lun Hwang Jong-Ho Cha Xiuwen Yan Wen-Hao Yang |
| author_facet | Xiaoxia Chi Shahang Luo Peng Ye Wei-Lun Hwang Wei-Lun Hwang Jong-Ho Cha Xiuwen Yan Wen-Hao Yang |
| author_sort | Xiaoxia Chi |
| collection | DOAJ |
| description | T cells play a crucial role in the regulation of immune response and are integral to the efficacy of cancer immunotherapy. Because immunotherapy has emerged as a promising treatment for cancer, increasing attention has been focused on the differentiation and function of T cells in immune response. In this review, we describe the research progress on T-cell exhaustion and stemness in the field of cancer immunotherapy and summarize advances in potential strategies to intervene and treat chronic infection and cancer by reversing T-cell exhaustion and maintaining and increasing T-cell stemness. Moreover, we discuss therapeutic strategies to overcome T-cell immunodeficiency in the tumor microenvironment and promote continuous breakthroughs in the anticancer activity of T cells. |
| first_indexed | 2024-04-10T09:25:02Z |
| format | Article |
| id | doaj.art-10a0eebc62d144d19788c7d900392e4d |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-10T09:25:02Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-10a0eebc62d144d19788c7d900392e4d2023-02-20T06:20:43ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-02-011410.3389/fimmu.2023.11047711104771T-cell exhaustion and stemness in antitumor immunity: Characteristics, mechanisms, and implicationsXiaoxia Chi0Shahang Luo1Peng Ye2Wei-Lun Hwang3Wei-Lun Hwang4Jong-Ho Cha5Xiuwen Yan6Wen-Hao Yang7Affiliated Cancer Hospital & Institute and Key Laboratory for Cell Homeostasis and Cancer Research of Guangdong Higher Education Institutes, Guangzhou Medical University, Guangzhou, Guangdong, ChinaAffiliated Cancer Hospital & Institute and Key Laboratory for Cell Homeostasis and Cancer Research of Guangdong Higher Education Institutes, Guangzhou Medical University, Guangzhou, Guangdong, ChinaDepartment of Infectious Diseases, Guangzhou Panyu Central Hospital, Guangzhou, Guangdong, ChinaDepartment of Biotechnology and Laboratory Science in Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanCancer Progression Research Center, National Yang Ming Chiao Tung University, Taipei, TaiwanDepartment of Biomedical Science, College of Medicine, and Program in Biomedical Sciences and Engineering, Inha University, Incheon, Republic of KoreaAffiliated Cancer Hospital & Institute and Key Laboratory for Cell Homeostasis and Cancer Research of Guangdong Higher Education Institutes, Guangzhou Medical University, Guangzhou, Guangdong, ChinaGraduate Institute of Biomedical Sciences, China Medical University, Taichung, TaiwanT cells play a crucial role in the regulation of immune response and are integral to the efficacy of cancer immunotherapy. Because immunotherapy has emerged as a promising treatment for cancer, increasing attention has been focused on the differentiation and function of T cells in immune response. In this review, we describe the research progress on T-cell exhaustion and stemness in the field of cancer immunotherapy and summarize advances in potential strategies to intervene and treat chronic infection and cancer by reversing T-cell exhaustion and maintaining and increasing T-cell stemness. Moreover, we discuss therapeutic strategies to overcome T-cell immunodeficiency in the tumor microenvironment and promote continuous breakthroughs in the anticancer activity of T cells.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1104771/fullexhaustionstemnessTSCMchronic antigenic stimulationcancer immunotherapy |
| spellingShingle | Xiaoxia Chi Shahang Luo Peng Ye Wei-Lun Hwang Wei-Lun Hwang Jong-Ho Cha Xiuwen Yan Wen-Hao Yang T-cell exhaustion and stemness in antitumor immunity: Characteristics, mechanisms, and implications Frontiers in Immunology exhaustion stemness TSCM chronic antigenic stimulation cancer immunotherapy |
| title | T-cell exhaustion and stemness in antitumor immunity: Characteristics, mechanisms, and implications |
| title_full | T-cell exhaustion and stemness in antitumor immunity: Characteristics, mechanisms, and implications |
| title_fullStr | T-cell exhaustion and stemness in antitumor immunity: Characteristics, mechanisms, and implications |
| title_full_unstemmed | T-cell exhaustion and stemness in antitumor immunity: Characteristics, mechanisms, and implications |
| title_short | T-cell exhaustion and stemness in antitumor immunity: Characteristics, mechanisms, and implications |
| title_sort | t cell exhaustion and stemness in antitumor immunity characteristics mechanisms and implications |
| topic | exhaustion stemness TSCM chronic antigenic stimulation cancer immunotherapy |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1104771/full |
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