Localized IgG4-related disease manifested on the tongue: a case report
Immunoglobulin G4-related disease (IgG4-RD) is an immune-mediated fibroinflammatory condition that can affect multiple organs. IgG4-RD may show a variety of initial symptoms. In the oral mucosa, lesions present as inflammatory fibrosis with a large number of IgG4-positive plasma cells. Evaluating tr...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Upsala Medical Society
2021-05-01
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| Series: | Upsala Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://ujms.net/index.php/ujms/article/view/6118/13543 |
| _version_ | 1797698941129588736 |
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| author | Helya Hashemi Andreas Thor Erik Hellbacher Marie Carlson Miklós Gulyás Lena Blomstrand |
| author_facet | Helya Hashemi Andreas Thor Erik Hellbacher Marie Carlson Miklós Gulyás Lena Blomstrand |
| author_sort | Helya Hashemi |
| collection | DOAJ |
| description | Immunoglobulin G4-related disease (IgG4-RD) is an immune-mediated fibroinflammatory condition that can affect multiple organs. IgG4-RD may show a variety of initial symptoms. In the oral mucosa, lesions present as inflammatory fibrosis with a large number of IgG4-positive plasma cells. Evaluating treatment is a well-known problem in IgG4-RD due to the absence of an established assessment system. There are difficulties in defining the severity of the disease, which is why treatment is primarily based on its clinical manifestations.We present a case report of localized IgG4-RD with ulcerative and proliferative manifestations on the tongue, which clinically mimicked oral squamous cell carcinoma. A tumor-like lesion on the tongue can indicate something else other than the malignant or reactive changes commonly found in the oral mucosa. Multiple differential diagnoses of these atypical oral lesions, including localized IgG4-RD, should be considered. |
| first_indexed | 2024-03-12T04:01:16Z |
| format | Article |
| id | doaj.art-10a0fb3e1199429f8b0d70286ad8f8c4 |
| institution | Directory Open Access Journal |
| issn | 0300-9734 2000-1967 |
| language | English |
| last_indexed | 2024-03-12T04:01:16Z |
| publishDate | 2021-05-01 |
| publisher | Upsala Medical Society |
| record_format | Article |
| series | Upsala Journal of Medical Sciences |
| spelling | doaj.art-10a0fb3e1199429f8b0d70286ad8f8c42023-09-03T11:32:58ZengUpsala Medical SocietyUpsala Journal of Medical Sciences0300-97342000-19672021-05-0112611010.48101/ujms.v126.61186118Localized IgG4-related disease manifested on the tongue: a case reportHelya Hashemi0Andreas Thor1Erik Hellbacher2Marie Carlson3Miklós Gulyás4Lena Blomstrand5Department of Surgical Sciences, Plastic & Oral and Maxillofacial Surgery, Uppsala University, Uppsala, SwedenDepartment of Surgical Sciences, Plastic & Oral and Maxillofacial Surgery, Uppsala University, Uppsala, SwedenDepartment of Medical Sciences, Section of Rheumatology, Uppsala University, Uppsala, SwedenDepartment of Medical Sciences, Gastroenterology Research Group, Uppsala University, Uppsala, SwedenDivision of Pathology, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, SwedenDepartment of Surgical Sciences, Plastic & Oral and Maxillofacial Surgery, Uppsala University, Uppsala, SwedenImmunoglobulin G4-related disease (IgG4-RD) is an immune-mediated fibroinflammatory condition that can affect multiple organs. IgG4-RD may show a variety of initial symptoms. In the oral mucosa, lesions present as inflammatory fibrosis with a large number of IgG4-positive plasma cells. Evaluating treatment is a well-known problem in IgG4-RD due to the absence of an established assessment system. There are difficulties in defining the severity of the disease, which is why treatment is primarily based on its clinical manifestations.We present a case report of localized IgG4-RD with ulcerative and proliferative manifestations on the tongue, which clinically mimicked oral squamous cell carcinoma. A tumor-like lesion on the tongue can indicate something else other than the malignant or reactive changes commonly found in the oral mucosa. Multiple differential diagnoses of these atypical oral lesions, including localized IgG4-RD, should be considered.https://ujms.net/index.php/ujms/article/view/6118/13543igg4-related diseaselocalizedoral lesiontonguedifferential diagnosishistopathologymonoclonal antibodyrituximab |
| spellingShingle | Helya Hashemi Andreas Thor Erik Hellbacher Marie Carlson Miklós Gulyás Lena Blomstrand Localized IgG4-related disease manifested on the tongue: a case report Upsala Journal of Medical Sciences igg4-related disease localized oral lesion tongue differential diagnosis histopathology monoclonal antibody rituximab |
| title | Localized IgG4-related disease manifested on the tongue: a case report |
| title_full | Localized IgG4-related disease manifested on the tongue: a case report |
| title_fullStr | Localized IgG4-related disease manifested on the tongue: a case report |
| title_full_unstemmed | Localized IgG4-related disease manifested on the tongue: a case report |
| title_short | Localized IgG4-related disease manifested on the tongue: a case report |
| title_sort | localized igg4 related disease manifested on the tongue a case report |
| topic | igg4-related disease localized oral lesion tongue differential diagnosis histopathology monoclonal antibody rituximab |
| url | https://ujms.net/index.php/ujms/article/view/6118/13543 |
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