Hyperbaric Oxygen (HBO) Reduce Expression of Hypoxia Inducible Factor-1 Alpha (HIF-1 alpha) and Endometriotic Tissue Size in Mice Model of Endometriosis
Hypoxia in endometriosis will increase the expression of Hypoxia Inducible Factor-1alpha (HIF1alpha) and its expression could be decreased by Hyperbaric Oxygen (HBO). This study aimed to analyze the effect of HBO 2.4 ATA for 3x30 minutes per day for 10 days on the expression of HIF-1 alpha and endom...
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| Format: | Article |
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EDP Sciences
2020-01-01
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| Series: | E3S Web of Conferences |
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| Online Access: | https://www.e3s-conferences.org/articles/e3sconf/pdf/2020/11/e3sconf_icvaes2020_01003.pdf |
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| author | Syahrizal Dedy Mustika Cut Renaldi Teuku Suryokusumo Mohammad G. Hendarto Hendy |
| author_facet | Syahrizal Dedy Mustika Cut Renaldi Teuku Suryokusumo Mohammad G. Hendarto Hendy |
| author_sort | Syahrizal Dedy |
| collection | DOAJ |
| description | Hypoxia in endometriosis will increase the expression of Hypoxia Inducible Factor-1alpha (HIF1alpha) and its expression could be decreased by Hyperbaric Oxygen (HBO). This study aimed to analyze the effect of HBO 2.4 ATA for 3x30 minutes per day for 10 days on the expression of HIF-1 alpha and endometriotic tissue size on mice model of endometriosis. This study was an experimental laboratory study with a separate pretest-posttest control group design. The mice were divided into three groups, the first was a pretest control group (which describes the condition after endometrium transplantation), the second was the endometriotic group that received hyperbaric oxygen, and the third was the endometriotic group that did not receive hyperbaric oxygen therapy. The endometriosis implant size in the peritoneal tissue was assessed and the immunohistochemistry examination was conducted to determine the expression of HIF-1 alpha. The endometriosis tissue size was reduced in the HBO group compared to the control and nonHBO group. The lowest expression of HIF-1 alpha was significantly found in HBO over the other group. The decrease of HIF1 alpha expression mediates the reduction of size endometriotic tissue due to the therapy of HBO. |
| first_indexed | 2024-12-16T16:38:48Z |
| format | Article |
| id | doaj.art-10a16968564a4de0af696ad23ab512ce |
| institution | Directory Open Access Journal |
| issn | 2267-1242 |
| language | English |
| last_indexed | 2024-12-16T16:38:48Z |
| publishDate | 2020-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | E3S Web of Conferences |
| spelling | doaj.art-10a16968564a4de0af696ad23ab512ce2022-12-21T22:24:22ZengEDP SciencesE3S Web of Conferences2267-12422020-01-011510100310.1051/e3sconf/202015101003e3sconf_icvaes2020_01003Hyperbaric Oxygen (HBO) Reduce Expression of Hypoxia Inducible Factor-1 Alpha (HIF-1 alpha) and Endometriotic Tissue Size in Mice Model of EndometriosisSyahrizal Dedy0Mustika Cut1Renaldi Teuku2Suryokusumo Mohammad G.3Hendarto Hendy4Department of Biochemistry, Medical Faculty, Universitas Syiah KualaDepartment of Public Health, Medical Faculty, Universitas Syiah KualaDepartment of Public Health, Medical Faculty, Universitas Syiah KualaMedical Hyperbaric Study Program, Faculty of Medicine, Universitas AirlanggaDepartment of Obstetrics and Gynaecology, Faculty of Medicine, Universitas AirlanggaHypoxia in endometriosis will increase the expression of Hypoxia Inducible Factor-1alpha (HIF1alpha) and its expression could be decreased by Hyperbaric Oxygen (HBO). This study aimed to analyze the effect of HBO 2.4 ATA for 3x30 minutes per day for 10 days on the expression of HIF-1 alpha and endometriotic tissue size on mice model of endometriosis. This study was an experimental laboratory study with a separate pretest-posttest control group design. The mice were divided into three groups, the first was a pretest control group (which describes the condition after endometrium transplantation), the second was the endometriotic group that received hyperbaric oxygen, and the third was the endometriotic group that did not receive hyperbaric oxygen therapy. The endometriosis implant size in the peritoneal tissue was assessed and the immunohistochemistry examination was conducted to determine the expression of HIF-1 alpha. The endometriosis tissue size was reduced in the HBO group compared to the control and nonHBO group. The lowest expression of HIF-1 alpha was significantly found in HBO over the other group. The decrease of HIF1 alpha expression mediates the reduction of size endometriotic tissue due to the therapy of HBO.https://www.e3s-conferences.org/articles/e3sconf/pdf/2020/11/e3sconf_icvaes2020_01003.pdfhypoxiaendometriosishyperbaric oxygen (hbo)hypoxia-inducible factor-1 alpha (hif-1α) |
| spellingShingle | Syahrizal Dedy Mustika Cut Renaldi Teuku Suryokusumo Mohammad G. Hendarto Hendy Hyperbaric Oxygen (HBO) Reduce Expression of Hypoxia Inducible Factor-1 Alpha (HIF-1 alpha) and Endometriotic Tissue Size in Mice Model of Endometriosis E3S Web of Conferences hypoxia endometriosis hyperbaric oxygen (hbo) hypoxia-inducible factor-1 alpha (hif-1α) |
| title | Hyperbaric Oxygen (HBO) Reduce Expression of Hypoxia Inducible Factor-1 Alpha (HIF-1 alpha) and Endometriotic Tissue Size in Mice Model of Endometriosis |
| title_full | Hyperbaric Oxygen (HBO) Reduce Expression of Hypoxia Inducible Factor-1 Alpha (HIF-1 alpha) and Endometriotic Tissue Size in Mice Model of Endometriosis |
| title_fullStr | Hyperbaric Oxygen (HBO) Reduce Expression of Hypoxia Inducible Factor-1 Alpha (HIF-1 alpha) and Endometriotic Tissue Size in Mice Model of Endometriosis |
| title_full_unstemmed | Hyperbaric Oxygen (HBO) Reduce Expression of Hypoxia Inducible Factor-1 Alpha (HIF-1 alpha) and Endometriotic Tissue Size in Mice Model of Endometriosis |
| title_short | Hyperbaric Oxygen (HBO) Reduce Expression of Hypoxia Inducible Factor-1 Alpha (HIF-1 alpha) and Endometriotic Tissue Size in Mice Model of Endometriosis |
| title_sort | hyperbaric oxygen hbo reduce expression of hypoxia inducible factor 1 alpha hif 1 alpha and endometriotic tissue size in mice model of endometriosis |
| topic | hypoxia endometriosis hyperbaric oxygen (hbo) hypoxia-inducible factor-1 alpha (hif-1α) |
| url | https://www.e3s-conferences.org/articles/e3sconf/pdf/2020/11/e3sconf_icvaes2020_01003.pdf |
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