A Setmelanotide-like Effect at MC4R Is Achieved by MC4R Dimer Separation

A Setmelanotide-like Effect at MC4R Is Achieved by MC4R Dimer Separation

Melanocortin 4 receptor (MC4R) is part of the leptin-melanocortin pathway and plays an essential role in mediating energy homeostasis. Mutations in the <i>MC4R</i> are the most frequent monogenic cause for obesity. Due to increasing numbers of people with excess body weight, the MC4R has...

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Bibliographic Details
Main Authors: Nanina Reininghaus, Sarah Paisdzior, Friederike Höpfner, Sabine Jyrch, Cigdem Cetindag, Patrick Scheerer, Peter Kühnen, Heike Biebermann
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Biomolecules
Subjects:
melanocortin 4 receptor
MC4R
obesity
homodimer
G<sub>q/11</sub>
signaling
Online Access:https://www.mdpi.com/2218-273X/12/8/1119

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