Lung microbiota associations with clinical features of COPD in the SPIROMICS cohort
Abstract Chronic obstructive pulmonary disease (COPD) is heterogeneous in development, progression, and phenotypes. Little is known about the lung microbiome, sampled by bronchoscopy, in milder COPD and its relationships to clinical features that reflect disease heterogeneity (lung function, symptom...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-02-01
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| Series: | npj Biofilms and Microbiomes |
| Online Access: | https://doi.org/10.1038/s41522-021-00185-9 |
| _version_ | 1818841022120067072 |
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| author | Kristopher Opron Lesa A. Begley John R. Erb-Downward Christine Freeman Siddharth Madapoosi Neil E. Alexis Igor Barjaktarevic R. Graham Barr Eugene R. Bleecker Russell P. Bowler Stephanie A. Christenson Alejandro P. Comellas Christopher B. Cooper David J. Couper Claire M. Doerschuk Mark T. Dransfield MeiLan K. Han Nadia N. Hansel Annette T. Hastie Eric A. Hoffman Robert J. Kaner Jerry Krishnan Wanda K. O’Neal Victor E. Ortega Robert Paine Stephen P. Peters J. Michael Wells Prescott G. Woodruff Fernando J. Martinez Jeffrey L. Curtis Gary B. Huffnagle Yvonne J. Huang |
| author_facet | Kristopher Opron Lesa A. Begley John R. Erb-Downward Christine Freeman Siddharth Madapoosi Neil E. Alexis Igor Barjaktarevic R. Graham Barr Eugene R. Bleecker Russell P. Bowler Stephanie A. Christenson Alejandro P. Comellas Christopher B. Cooper David J. Couper Claire M. Doerschuk Mark T. Dransfield MeiLan K. Han Nadia N. Hansel Annette T. Hastie Eric A. Hoffman Robert J. Kaner Jerry Krishnan Wanda K. O’Neal Victor E. Ortega Robert Paine Stephen P. Peters J. Michael Wells Prescott G. Woodruff Fernando J. Martinez Jeffrey L. Curtis Gary B. Huffnagle Yvonne J. Huang |
| author_sort | Kristopher Opron |
| collection | DOAJ |
| description | Abstract Chronic obstructive pulmonary disease (COPD) is heterogeneous in development, progression, and phenotypes. Little is known about the lung microbiome, sampled by bronchoscopy, in milder COPD and its relationships to clinical features that reflect disease heterogeneity (lung function, symptom burden, and functional impairment). Using bronchoalveolar lavage fluid collected from 181 never-smokers and ever-smokers with or without COPD (GOLD 0-2) enrolled in the SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS), we find that lung bacterial composition associates with several clinical features, in particular bronchodilator responsiveness, peak expiratory flow rate, and forced expiratory flow rate between 25 and 75% of FVC (FEF25–75). Measures of symptom burden (COPD Assessment Test) and functional impairment (six-minute walk distance) also associate with disparate lung microbiota composition. Drivers of these relationships include members of the Streptococcus, Prevotella, Veillonella, Staphylococcus, and Pseudomonas genera. Thus, lung microbiota differences may contribute to airway dysfunction and airway disease in milder COPD. |
| first_indexed | 2024-12-19T04:19:28Z |
| format | Article |
| id | doaj.art-10a254afe79640d29b0d02561b498bb0 |
| institution | Directory Open Access Journal |
| issn | 2055-5008 |
| language | English |
| last_indexed | 2024-12-19T04:19:28Z |
| publishDate | 2021-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Biofilms and Microbiomes |
| spelling | doaj.art-10a254afe79640d29b0d02561b498bb02022-12-21T20:36:12ZengNature Portfolionpj Biofilms and Microbiomes2055-50082021-02-017111010.1038/s41522-021-00185-9Lung microbiota associations with clinical features of COPD in the SPIROMICS cohortKristopher Opron0Lesa A. Begley1John R. Erb-Downward2Christine Freeman3Siddharth Madapoosi4Neil E. Alexis5Igor Barjaktarevic6R. Graham Barr7Eugene R. Bleecker8Russell P. Bowler9Stephanie A. Christenson10Alejandro P. Comellas11Christopher B. Cooper12David J. Couper13Claire M. Doerschuk14Mark T. Dransfield15MeiLan K. Han16Nadia N. Hansel17Annette T. Hastie18Eric A. Hoffman19Robert J. Kaner20Jerry Krishnan21Wanda K. O’Neal22Victor E. Ortega23Robert Paine24Stephen P. Peters25J. Michael Wells26Prescott G. Woodruff27Fernando J. Martinez28Jeffrey L. Curtis29Gary B. Huffnagle30Yvonne J. Huang31Division of Pulmonary/Critical Care Medicine, University of MichiganDivision of Pulmonary/Critical Care Medicine, University of MichiganDivision of Pulmonary/Critical Care Medicine, University of MichiganDivision of Pulmonary/Critical Care Medicine, University of MichiganDivision of Pulmonary/Critical Care Medicine, University of MichiganUniversity of North Carolina at Chapel HillUniversity of California at Los AngelesColumbia UniversityUniversity of Arizona College of MedicineNational Jewish HealthUniversity of California at San FranciscoUniversity of IowaUniversity of California at Los AngelesUniversity of North Carolina at Chapel HillUniversity of North Carolina at Chapel HillUniversity of Alabama at BirminghamDivision of Pulmonary/Critical Care Medicine, University of MichiganJohn Hopkins UniversityWake Forest School of MedicineUniversity of IowaWeill Cornell Medical CollegeUniversity of IllinoisUniversity of North Carolina at Chapel HillWake Forest School of MedicineUniversity of UtahWake Forest School of MedicineUniversity of Alabama at BirminghamUniversity of California at San FranciscoWeill Cornell Medical CollegeDivision of Pulmonary/Critical Care Medicine, University of MichiganDivision of Pulmonary/Critical Care Medicine, University of MichiganDivision of Pulmonary/Critical Care Medicine, University of MichiganAbstract Chronic obstructive pulmonary disease (COPD) is heterogeneous in development, progression, and phenotypes. Little is known about the lung microbiome, sampled by bronchoscopy, in milder COPD and its relationships to clinical features that reflect disease heterogeneity (lung function, symptom burden, and functional impairment). Using bronchoalveolar lavage fluid collected from 181 never-smokers and ever-smokers with or without COPD (GOLD 0-2) enrolled in the SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS), we find that lung bacterial composition associates with several clinical features, in particular bronchodilator responsiveness, peak expiratory flow rate, and forced expiratory flow rate between 25 and 75% of FVC (FEF25–75). Measures of symptom burden (COPD Assessment Test) and functional impairment (six-minute walk distance) also associate with disparate lung microbiota composition. Drivers of these relationships include members of the Streptococcus, Prevotella, Veillonella, Staphylococcus, and Pseudomonas genera. Thus, lung microbiota differences may contribute to airway dysfunction and airway disease in milder COPD.https://doi.org/10.1038/s41522-021-00185-9 |
| spellingShingle | Kristopher Opron Lesa A. Begley John R. Erb-Downward Christine Freeman Siddharth Madapoosi Neil E. Alexis Igor Barjaktarevic R. Graham Barr Eugene R. Bleecker Russell P. Bowler Stephanie A. Christenson Alejandro P. Comellas Christopher B. Cooper David J. Couper Claire M. Doerschuk Mark T. Dransfield MeiLan K. Han Nadia N. Hansel Annette T. Hastie Eric A. Hoffman Robert J. Kaner Jerry Krishnan Wanda K. O’Neal Victor E. Ortega Robert Paine Stephen P. Peters J. Michael Wells Prescott G. Woodruff Fernando J. Martinez Jeffrey L. Curtis Gary B. Huffnagle Yvonne J. Huang Lung microbiota associations with clinical features of COPD in the SPIROMICS cohort npj Biofilms and Microbiomes |
| title | Lung microbiota associations with clinical features of COPD in the SPIROMICS cohort |
| title_full | Lung microbiota associations with clinical features of COPD in the SPIROMICS cohort |
| title_fullStr | Lung microbiota associations with clinical features of COPD in the SPIROMICS cohort |
| title_full_unstemmed | Lung microbiota associations with clinical features of COPD in the SPIROMICS cohort |
| title_short | Lung microbiota associations with clinical features of COPD in the SPIROMICS cohort |
| title_sort | lung microbiota associations with clinical features of copd in the spiromics cohort |
| url | https://doi.org/10.1038/s41522-021-00185-9 |
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