Restorative Dental Resin Functionalized with Calcium Methacrylate with a Hydroxyapatite Remineralization Capacity
The ability of dental materials to induce the mineralization of enamel like hydroxyapatite (HA) is of great importance. In this article, a novel kind of dental restorative material characterized by a mineralization ability was fabricated by photopolymerization. Calcium methacrylate (CMA) was introdu...
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MDPI AG
2023-09-01
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| author | Xin Zhang Yuxuan Zhang Ying Li Xiaoming Wang Xueqin Zhang |
| author_facet | Xin Zhang Yuxuan Zhang Ying Li Xiaoming Wang Xueqin Zhang |
| author_sort | Xin Zhang |
| collection | DOAJ |
| description | The ability of dental materials to induce the mineralization of enamel like hydroxyapatite (HA) is of great importance. In this article, a novel kind of dental restorative material characterized by a mineralization ability was fabricated by photopolymerization. Calcium methacrylate (CMA) was introduced into the classical bisphenol A-glycidyl methacrylate (Bis-GMA) and triethylene glycol dimethacrylate (TEGDMA) dental resin formulation. This functional dental resin (BTCM) was calcium-rich and can be prepared simply by one-step photopolymerization. The influence of CMA on the photopolymerization kinetics, the dental resin’s mechanical properties, and its capacity to induce dynamic in situ HA mineralization were examined. Real-time FTIR, compression modulus, scanning electron microscopy, X-ray spectroscopy, MTT assay, and cell attachment test were carried out. The obtained data were analyzed for statistical significance using analysis of variance (ANOVA). Double bond conversion could be completed in less than 300 s, while the compression modulus of BTCM decreased with the increase in CMA content (30 wt%, 40 wt%, and 50 wt%). After being soaked in Ca(NO<sub>3</sub>)<sub>2</sub> and Na<sub>2</sub>HPO<sub>4</sub> solutions alternatively, dense HA crystals were found on the surface of the dental resin which contained CMA. The amount of HA increased with the increase in CMA content. The MTT results indicated that BTCM possesses good biocompatibility, while the cell adhesion and proliferation investigation demonstrated that L929 cells can adhere and proliferate well on the surface of BTM. Thus, our approach provides a straightforward, cost-effective, and environmentally friendly solution that has the potential for immediate clinical use. |
| first_indexed | 2024-03-10T21:40:25Z |
| format | Article |
| id | doaj.art-10a471c88b7044b6a82b2b9825bc4617 |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-10T21:40:25Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
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| series | Materials |
| spelling | doaj.art-10a471c88b7044b6a82b2b9825bc46172023-11-19T14:40:42ZengMDPI AGMaterials1996-19442023-09-011619649710.3390/ma16196497Restorative Dental Resin Functionalized with Calcium Methacrylate with a Hydroxyapatite Remineralization CapacityXin Zhang0Yuxuan Zhang1Ying Li2Xiaoming Wang3Xueqin Zhang4College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing 100048, ChinaFuYang Sineva Materials Technology Co., Ltd., Beijing 100176, ChinaCollege of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing 100048, ChinaShuozhou Comprehensive Inspection and Testing Center, Shuozhou 036000, ChinaCollege of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing 100048, ChinaThe ability of dental materials to induce the mineralization of enamel like hydroxyapatite (HA) is of great importance. In this article, a novel kind of dental restorative material characterized by a mineralization ability was fabricated by photopolymerization. Calcium methacrylate (CMA) was introduced into the classical bisphenol A-glycidyl methacrylate (Bis-GMA) and triethylene glycol dimethacrylate (TEGDMA) dental resin formulation. This functional dental resin (BTCM) was calcium-rich and can be prepared simply by one-step photopolymerization. The influence of CMA on the photopolymerization kinetics, the dental resin’s mechanical properties, and its capacity to induce dynamic in situ HA mineralization were examined. Real-time FTIR, compression modulus, scanning electron microscopy, X-ray spectroscopy, MTT assay, and cell attachment test were carried out. The obtained data were analyzed for statistical significance using analysis of variance (ANOVA). Double bond conversion could be completed in less than 300 s, while the compression modulus of BTCM decreased with the increase in CMA content (30 wt%, 40 wt%, and 50 wt%). After being soaked in Ca(NO<sub>3</sub>)<sub>2</sub> and Na<sub>2</sub>HPO<sub>4</sub> solutions alternatively, dense HA crystals were found on the surface of the dental resin which contained CMA. The amount of HA increased with the increase in CMA content. The MTT results indicated that BTCM possesses good biocompatibility, while the cell adhesion and proliferation investigation demonstrated that L929 cells can adhere and proliferate well on the surface of BTM. Thus, our approach provides a straightforward, cost-effective, and environmentally friendly solution that has the potential for immediate clinical use.https://www.mdpi.com/1996-1944/16/19/6497dentistrydental materialsdental resinphotopolymerizationhydroxyapatitecalcium methacrylate |
| spellingShingle | Xin Zhang Yuxuan Zhang Ying Li Xiaoming Wang Xueqin Zhang Restorative Dental Resin Functionalized with Calcium Methacrylate with a Hydroxyapatite Remineralization Capacity Materials dentistry dental materials dental resin photopolymerization hydroxyapatite calcium methacrylate |
| title | Restorative Dental Resin Functionalized with Calcium Methacrylate with a Hydroxyapatite Remineralization Capacity |
| title_full | Restorative Dental Resin Functionalized with Calcium Methacrylate with a Hydroxyapatite Remineralization Capacity |
| title_fullStr | Restorative Dental Resin Functionalized with Calcium Methacrylate with a Hydroxyapatite Remineralization Capacity |
| title_full_unstemmed | Restorative Dental Resin Functionalized with Calcium Methacrylate with a Hydroxyapatite Remineralization Capacity |
| title_short | Restorative Dental Resin Functionalized with Calcium Methacrylate with a Hydroxyapatite Remineralization Capacity |
| title_sort | restorative dental resin functionalized with calcium methacrylate with a hydroxyapatite remineralization capacity |
| topic | dentistry dental materials dental resin photopolymerization hydroxyapatite calcium methacrylate |
| url | https://www.mdpi.com/1996-1944/16/19/6497 |
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