Recombinant Chromosomes Resulting From Parental Pericentric Inversions—Two New Cases and a Review of the Literature

Recombinant Chromosomes Resulting From Parental Pericentric Inversions—Two New Cases and a Review of the Literature

A balanced pericentric inversion is normally without any clinical consequences for its carrier. However, there is a well-known risk of such inversions to lead to unbalanced offspring. Inversion-loop formation is the mechanism which may lead to duplication or deletion of the entire or parts of the in...

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Bibliographic Details
Main Authors: Thomas Liehr, Anja Weise, Kristin Mrasek, Monika Ziegler, Niklas Padutsch, Kathleen Wilhelm, Ahmed Al-Rikabi
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Genetics
Subjects:
balanced pericentric inversion
recombinant chromosomes
dosage sensitive genes
duplication
deletion
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.01165/full

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