Simultaneous evaluation of metabolomic and inflammatory biomarkers in children with different body mass index (BMI) and waist-to-height ratio (WHtR).
Metabolic disturbances and systemic pro-inflammatory changes have been reported in children with obesity. However, it is unclear the time-sequence of metabolic or inflammatory modifications during children obesity evolution. Our study aimed to quantify simultaneously metabolomic and inflammatory bio...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2020-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0237917 |
| _version_ | 1818917078457909248 |
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| author | Erika Chavira-Suárez Cecilia Rosel-Pech Ernestina Polo-Oteyza Mónica Ancira-Moreno Isabel Ibarra-González Marcela Vela-Amieva Noemi Meraz-Cruz Carlos Aguilar-Salinas Felipe Vadillo-Ortega |
| author_facet | Erika Chavira-Suárez Cecilia Rosel-Pech Ernestina Polo-Oteyza Mónica Ancira-Moreno Isabel Ibarra-González Marcela Vela-Amieva Noemi Meraz-Cruz Carlos Aguilar-Salinas Felipe Vadillo-Ortega |
| author_sort | Erika Chavira-Suárez |
| collection | DOAJ |
| description | Metabolic disturbances and systemic pro-inflammatory changes have been reported in children with obesity. However, it is unclear the time-sequence of metabolic or inflammatory modifications during children obesity evolution. Our study aimed to quantify simultaneously metabolomic and inflammatory biomarkers in serum from children with different levels of adiposity. For this purpose, a cross-sectional study was used to perform targeted metabolomics and inflammatory cytokines measurements. Serum samples from children between six to ten years old were analyzed using either body mass index (BMI) or waist-to-height ratio (WHtR) classifications. One hundred and sixty-eight school-aged children were included. BMI classification in children with overweight or obesity showed altered concentrations of glucose and amino acids (glycine and tyrosine). Children classified by WHtR exhibited imbalances in amino acids (glycine, valine, and tyrosine) and lipids (triacyl glycerides and low-density lipoprotein) compared to control group. No differences in systemic inflammation biomarkers or in the prevalence of other results were found in these children. Abnormal arterial blood pressure was found in 32% of children with increased adiposity. In conclusion, obesity in school-aged children is characterized by significant metabolic modifications that are not accompanied by major disturbances in circulating concentrations of inflammatory biomarkers. |
| first_indexed | 2024-12-20T00:28:21Z |
| format | Article |
| id | doaj.art-10a7128834f44d279de99ff69e5cdcb8 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T00:28:21Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-10a7128834f44d279de99ff69e5cdcb82022-12-21T20:00:00ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-01158e023791710.1371/journal.pone.0237917Simultaneous evaluation of metabolomic and inflammatory biomarkers in children with different body mass index (BMI) and waist-to-height ratio (WHtR).Erika Chavira-SuárezCecilia Rosel-PechErnestina Polo-OteyzaMónica Ancira-MorenoIsabel Ibarra-GonzálezMarcela Vela-AmievaNoemi Meraz-CruzCarlos Aguilar-SalinasFelipe Vadillo-OrtegaMetabolic disturbances and systemic pro-inflammatory changes have been reported in children with obesity. However, it is unclear the time-sequence of metabolic or inflammatory modifications during children obesity evolution. Our study aimed to quantify simultaneously metabolomic and inflammatory biomarkers in serum from children with different levels of adiposity. For this purpose, a cross-sectional study was used to perform targeted metabolomics and inflammatory cytokines measurements. Serum samples from children between six to ten years old were analyzed using either body mass index (BMI) or waist-to-height ratio (WHtR) classifications. One hundred and sixty-eight school-aged children were included. BMI classification in children with overweight or obesity showed altered concentrations of glucose and amino acids (glycine and tyrosine). Children classified by WHtR exhibited imbalances in amino acids (glycine, valine, and tyrosine) and lipids (triacyl glycerides and low-density lipoprotein) compared to control group. No differences in systemic inflammation biomarkers or in the prevalence of other results were found in these children. Abnormal arterial blood pressure was found in 32% of children with increased adiposity. In conclusion, obesity in school-aged children is characterized by significant metabolic modifications that are not accompanied by major disturbances in circulating concentrations of inflammatory biomarkers.https://doi.org/10.1371/journal.pone.0237917 |
| spellingShingle | Erika Chavira-Suárez Cecilia Rosel-Pech Ernestina Polo-Oteyza Mónica Ancira-Moreno Isabel Ibarra-González Marcela Vela-Amieva Noemi Meraz-Cruz Carlos Aguilar-Salinas Felipe Vadillo-Ortega Simultaneous evaluation of metabolomic and inflammatory biomarkers in children with different body mass index (BMI) and waist-to-height ratio (WHtR). PLoS ONE |
| title | Simultaneous evaluation of metabolomic and inflammatory biomarkers in children with different body mass index (BMI) and waist-to-height ratio (WHtR). |
| title_full | Simultaneous evaluation of metabolomic and inflammatory biomarkers in children with different body mass index (BMI) and waist-to-height ratio (WHtR). |
| title_fullStr | Simultaneous evaluation of metabolomic and inflammatory biomarkers in children with different body mass index (BMI) and waist-to-height ratio (WHtR). |
| title_full_unstemmed | Simultaneous evaluation of metabolomic and inflammatory biomarkers in children with different body mass index (BMI) and waist-to-height ratio (WHtR). |
| title_short | Simultaneous evaluation of metabolomic and inflammatory biomarkers in children with different body mass index (BMI) and waist-to-height ratio (WHtR). |
| title_sort | simultaneous evaluation of metabolomic and inflammatory biomarkers in children with different body mass index bmi and waist to height ratio whtr |
| url | https://doi.org/10.1371/journal.pone.0237917 |
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