Hypoxia and low-glucose environments co-induced HGDILnc1 promote glycolysis and angiogenesis
Abstract Small bowel vascular malformation disease (SBVM) commonly causes obscure gastrointestinal bleeding (OGIB). However, the pathogenetic mechanism and the role of lncRNAs in SBVM remain largely unknown. Here, we found that hypoxia and low-glucose environments co-augment angiogenesis and existed...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2024-03-01
|
| Series: | Cell Death Discovery |
| Online Access: | https://doi.org/10.1038/s41420-024-01903-w |
| _version_ | 1827316227741057024 |
|---|---|
| author | Qing-Wei Zhang Xiao-Lu Lin Zi-Hao Dai Ran Zhao Yi-Chao Hou Qian Liang Yan Zhang Zhi-Zheng Ge |
| author_facet | Qing-Wei Zhang Xiao-Lu Lin Zi-Hao Dai Ran Zhao Yi-Chao Hou Qian Liang Yan Zhang Zhi-Zheng Ge |
| author_sort | Qing-Wei Zhang |
| collection | DOAJ |
| description | Abstract Small bowel vascular malformation disease (SBVM) commonly causes obscure gastrointestinal bleeding (OGIB). However, the pathogenetic mechanism and the role of lncRNAs in SBVM remain largely unknown. Here, we found that hypoxia and low-glucose environments co-augment angiogenesis and existed in SBVM. Mechanistically, hypoxia and low-glucose environments supported angiogenesis via activation of hypoxia and glucose deprivation-induced lncRNA (HGDILnc1) transcription by increasing binding of the NeuroD1 transcription factor to the HGDILnc1 promoter. Raised HGDILnc1 acted as a suppressor of α-Enolase 1 (ENO1) small ubiquitin-like modifier modification (SUMOylation)-triggered ubiquitination, and an activator of transcription of Aldolase C (ALDOC) via upregulation of Histone H2B lysine 16 acetylation (H2BK16ac) level in the promoter of ALDOC, and consequently promoting glycolysis and angiogenesis. Moreover, HGDILnc1 was clinically positively correlated with Neurogenic differentiation 1 (NeuroD1), ENO1, and ALDOC in SBVM tissues, and could function as a biomarker for SBVM diagnosis and therapy. These findings suggest that hypoxia and low-glucose environments were present in SBVM tissues, and co-augmented angiogenesis. Hypoxia and low-glucose environments co-induced HGDILnc1, which is higher expressed in SBVM tissue compared with normal tissue, could promoted glycolysis and angiogenesis. |
| first_indexed | 2024-04-24T23:10:03Z |
| format | Article |
| id | doaj.art-10a7e9d53f2b4c47b1e709c7b58dcc52 |
| institution | Directory Open Access Journal |
| issn | 2058-7716 |
| language | English |
| last_indexed | 2024-04-24T23:10:03Z |
| publishDate | 2024-03-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death Discovery |
| spelling | doaj.art-10a7e9d53f2b4c47b1e709c7b58dcc522024-03-17T12:14:37ZengNature Publishing GroupCell Death Discovery2058-77162024-03-0110111410.1038/s41420-024-01903-wHypoxia and low-glucose environments co-induced HGDILnc1 promote glycolysis and angiogenesisQing-Wei Zhang0Xiao-Lu Lin1Zi-Hao Dai2Ran Zhao3Yi-Chao Hou4Qian Liang5Yan Zhang6Zhi-Zheng Ge7Division of Gastroenterology and Hepatology, NHC Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive DiseaseDepartment of Digestive Endoscopy Center, Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical UniversityDivision of Gastroenterology and Hepatology, NHC Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive DiseaseDepartment of Gastroenterology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical SciencesDepartment of Gastroenterology, Shanghai Nineth People’s Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Gastroenterology, Tongji Institute of Digestive Diseases, Tongji Hospital, School of Medicine, Tongji UniversityDivision of Gastroenterology and Hepatology, NHC Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive DiseaseDivision of Gastroenterology and Hepatology, NHC Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive DiseaseAbstract Small bowel vascular malformation disease (SBVM) commonly causes obscure gastrointestinal bleeding (OGIB). However, the pathogenetic mechanism and the role of lncRNAs in SBVM remain largely unknown. Here, we found that hypoxia and low-glucose environments co-augment angiogenesis and existed in SBVM. Mechanistically, hypoxia and low-glucose environments supported angiogenesis via activation of hypoxia and glucose deprivation-induced lncRNA (HGDILnc1) transcription by increasing binding of the NeuroD1 transcription factor to the HGDILnc1 promoter. Raised HGDILnc1 acted as a suppressor of α-Enolase 1 (ENO1) small ubiquitin-like modifier modification (SUMOylation)-triggered ubiquitination, and an activator of transcription of Aldolase C (ALDOC) via upregulation of Histone H2B lysine 16 acetylation (H2BK16ac) level in the promoter of ALDOC, and consequently promoting glycolysis and angiogenesis. Moreover, HGDILnc1 was clinically positively correlated with Neurogenic differentiation 1 (NeuroD1), ENO1, and ALDOC in SBVM tissues, and could function as a biomarker for SBVM diagnosis and therapy. These findings suggest that hypoxia and low-glucose environments were present in SBVM tissues, and co-augmented angiogenesis. Hypoxia and low-glucose environments co-induced HGDILnc1, which is higher expressed in SBVM tissue compared with normal tissue, could promoted glycolysis and angiogenesis.https://doi.org/10.1038/s41420-024-01903-w |
| spellingShingle | Qing-Wei Zhang Xiao-Lu Lin Zi-Hao Dai Ran Zhao Yi-Chao Hou Qian Liang Yan Zhang Zhi-Zheng Ge Hypoxia and low-glucose environments co-induced HGDILnc1 promote glycolysis and angiogenesis Cell Death Discovery |
| title | Hypoxia and low-glucose environments co-induced HGDILnc1 promote glycolysis and angiogenesis |
| title_full | Hypoxia and low-glucose environments co-induced HGDILnc1 promote glycolysis and angiogenesis |
| title_fullStr | Hypoxia and low-glucose environments co-induced HGDILnc1 promote glycolysis and angiogenesis |
| title_full_unstemmed | Hypoxia and low-glucose environments co-induced HGDILnc1 promote glycolysis and angiogenesis |
| title_short | Hypoxia and low-glucose environments co-induced HGDILnc1 promote glycolysis and angiogenesis |
| title_sort | hypoxia and low glucose environments co induced hgdilnc1 promote glycolysis and angiogenesis |
| url | https://doi.org/10.1038/s41420-024-01903-w |
| work_keys_str_mv | AT qingweizhang hypoxiaandlowglucoseenvironmentscoinducedhgdilnc1promoteglycolysisandangiogenesis AT xiaolulin hypoxiaandlowglucoseenvironmentscoinducedhgdilnc1promoteglycolysisandangiogenesis AT zihaodai hypoxiaandlowglucoseenvironmentscoinducedhgdilnc1promoteglycolysisandangiogenesis AT ranzhao hypoxiaandlowglucoseenvironmentscoinducedhgdilnc1promoteglycolysisandangiogenesis AT yichaohou hypoxiaandlowglucoseenvironmentscoinducedhgdilnc1promoteglycolysisandangiogenesis AT qianliang hypoxiaandlowglucoseenvironmentscoinducedhgdilnc1promoteglycolysisandangiogenesis AT yanzhang hypoxiaandlowglucoseenvironmentscoinducedhgdilnc1promoteglycolysisandangiogenesis AT zhizhengge hypoxiaandlowglucoseenvironmentscoinducedhgdilnc1promoteglycolysisandangiogenesis |