Exosomal microRNAs in diabetic heart disease
Abstract Diabetes is a metabolic disorder that affects millions of people worldwide. Diabetic heart disease (DHD) comprises coronary artery disease, heart failure, cardiac autonomic neuropathy, peripheral arterial disease, and diabetic cardiomyopathy. The onset and progression of DHD have been attri...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2022-07-01
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| Series: | Cardiovascular Diabetology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12933-022-01544-2 |
| _version_ | 1818234107390328832 |
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| author | Dhananjie Chandrasekera Rajesh Katare |
| author_facet | Dhananjie Chandrasekera Rajesh Katare |
| author_sort | Dhananjie Chandrasekera |
| collection | DOAJ |
| description | Abstract Diabetes is a metabolic disorder that affects millions of people worldwide. Diabetic heart disease (DHD) comprises coronary artery disease, heart failure, cardiac autonomic neuropathy, peripheral arterial disease, and diabetic cardiomyopathy. The onset and progression of DHD have been attributed to molecular alterations in response to hyperglycemia in diabetes. In this context, microRNAs (miRNAs) have been demonstrated to have a significant role in the development and progression of DHD. In addition to their effects on the host cells, miRNAs can be released into circulation after encapsulation within the exosomes. Exosomes are extracellular nanovesicles ranging from 30 to 180 nm in diameter secreted by all cell types. They carry diverse cargos that are altered in response to various conditions in their parent cells. Exosomal miRNAs have been extensively studied in recent years due to their role and therapeutic potential in DHD. This review will first provide an overview of exosomes, their biogenesis and function, followed by the role of exosomes in cardiovascular disease and then focuses on the known role of exosomes and associated miRNAs in DHD. |
| first_indexed | 2024-12-12T11:32:49Z |
| format | Article |
| id | doaj.art-10a9c23eb1634e3ebe7c22998e214add |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-12-12T11:32:49Z |
| publishDate | 2022-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-10a9c23eb1634e3ebe7c22998e214add2022-12-22T00:25:43ZengBMCCardiovascular Diabetology1475-28402022-07-0121111810.1186/s12933-022-01544-2Exosomal microRNAs in diabetic heart diseaseDhananjie Chandrasekera0Rajesh Katare1Department of Physiology, School of Biomedical Sciences, HeartOtago, University of OtagoDepartment of Physiology, School of Biomedical Sciences, HeartOtago, University of OtagoAbstract Diabetes is a metabolic disorder that affects millions of people worldwide. Diabetic heart disease (DHD) comprises coronary artery disease, heart failure, cardiac autonomic neuropathy, peripheral arterial disease, and diabetic cardiomyopathy. The onset and progression of DHD have been attributed to molecular alterations in response to hyperglycemia in diabetes. In this context, microRNAs (miRNAs) have been demonstrated to have a significant role in the development and progression of DHD. In addition to their effects on the host cells, miRNAs can be released into circulation after encapsulation within the exosomes. Exosomes are extracellular nanovesicles ranging from 30 to 180 nm in diameter secreted by all cell types. They carry diverse cargos that are altered in response to various conditions in their parent cells. Exosomal miRNAs have been extensively studied in recent years due to their role and therapeutic potential in DHD. This review will first provide an overview of exosomes, their biogenesis and function, followed by the role of exosomes in cardiovascular disease and then focuses on the known role of exosomes and associated miRNAs in DHD.https://doi.org/10.1186/s12933-022-01544-2Diabetic heart diseaseExosomesmicroRNAsBiomarkersAngiogenesisAtherosclerosis |
| spellingShingle | Dhananjie Chandrasekera Rajesh Katare Exosomal microRNAs in diabetic heart disease Cardiovascular Diabetology Diabetic heart disease Exosomes microRNAs Biomarkers Angiogenesis Atherosclerosis |
| title | Exosomal microRNAs in diabetic heart disease |
| title_full | Exosomal microRNAs in diabetic heart disease |
| title_fullStr | Exosomal microRNAs in diabetic heart disease |
| title_full_unstemmed | Exosomal microRNAs in diabetic heart disease |
| title_short | Exosomal microRNAs in diabetic heart disease |
| title_sort | exosomal micrornas in diabetic heart disease |
| topic | Diabetic heart disease Exosomes microRNAs Biomarkers Angiogenesis Atherosclerosis |
| url | https://doi.org/10.1186/s12933-022-01544-2 |
| work_keys_str_mv | AT dhananjiechandrasekera exosomalmicrornasindiabeticheartdisease AT rajeshkatare exosomalmicrornasindiabeticheartdisease |