Brain functional changes in patients with Crohn's disease: A resting‐state fMRI study
Abstract Background Crohn's disease (CD) is a chronic recurrent intestinal inflammatory disease, often accompanied by poor adaptation and excessive stress response. However, the potential neurological mechanisms of these symptoms have not yet been studied in‐depth. Objective To investigate alte...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-08-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.2243 |
| _version_ | 1827877361118347264 |
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| author | Lu Li Jie Ma Jian‐Guang Xu Yan‐Ling Zheng Qian Xie Lan Rong Zong‐Hui Liang |
| author_facet | Lu Li Jie Ma Jian‐Guang Xu Yan‐Ling Zheng Qian Xie Lan Rong Zong‐Hui Liang |
| author_sort | Lu Li |
| collection | DOAJ |
| description | Abstract Background Crohn's disease (CD) is a chronic recurrent intestinal inflammatory disease, often accompanied by poor adaptation and excessive stress response. However, the potential neurological mechanisms of these symptoms have not yet been studied in‐depth. Objective To investigate alterations in brain activity in patients with Crohn's disease and study the relationship between altered regions and clinical indices. Methods A total of 15 CD patients and 26 matched healthy controls were recruited. All participants underwent fMRI scans. The amplitude of low‐frequency fluctuations (ALFF) and regional homogeneity (ReHo) assessed differences in spontaneous regional brain activity. Differences between the groups were selected as seeds for functional connectivity (FC) analyses. Correlations between disease duration and ALFF/ReHo/FC values in abnormal regions were analyzed. Results Patients with CD had significantly higher ALFF values in the left superior frontal gyrus, anterior cingulate cortex, and supplementary motor area, and lower values in the left hippocampus. They also had higher ReHo values in the left anterior cingulate cortex, supplementary motor area, putamen, and the bilateral superior frontal gyri. FC strength in the left precentral and middle temporal gyri was found to be increased when the left superior frontal gyrus was used as the seed point. FC strength was also observed to be increased in the left postcentral, middle frontal gyri, inferior frontal orbital cortex, and right rolandic operculum when the left anterior cingulate cortex was used as the seed point. Conclusion CD demonstrated abnormal neural activity and FC in various regions primarily associated with emotional, pain and cognitive‐related functions, which provides more information to further understand the neural mechanisms of the disease. |
| first_indexed | 2024-03-12T17:36:18Z |
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| id | doaj.art-10a9cc0dc7b74a1bb5e5ab93d3bd543a |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-03-12T17:36:18Z |
| publishDate | 2021-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-10a9cc0dc7b74a1bb5e5ab93d3bd543a2023-08-04T10:56:25ZengWileyBrain and Behavior2162-32792021-08-01118n/an/a10.1002/brb3.2243Brain functional changes in patients with Crohn's disease: A resting‐state fMRI studyLu Li0Jie Ma1Jian‐Guang Xu2Yan‐Ling Zheng3Qian Xie4Lan Rong5Zong‐Hui Liang6Department of Radiology, Jing'an District Centre Hospital of Shanghai Fudan University Shanghai ChinaSchool of Rehabilitation Science Shanghai University of Traditional Chinese Medicine Shanghai ChinaSchool of Rehabilitation Science Shanghai University of Traditional Chinese Medicine Shanghai ChinaDepartment of Radiology, Jing'an District Centre Hospital of Shanghai Fudan University Shanghai ChinaDepartment of Radiology, Jing'an District Centre Hospital of Shanghai Fudan University Shanghai ChinaDepartment of Gastroenterology, Huashan Hospital Fudan University Shanghai ChinaDepartment of Radiology, Jing'an District Centre Hospital of Shanghai Fudan University Shanghai ChinaAbstract Background Crohn's disease (CD) is a chronic recurrent intestinal inflammatory disease, often accompanied by poor adaptation and excessive stress response. However, the potential neurological mechanisms of these symptoms have not yet been studied in‐depth. Objective To investigate alterations in brain activity in patients with Crohn's disease and study the relationship between altered regions and clinical indices. Methods A total of 15 CD patients and 26 matched healthy controls were recruited. All participants underwent fMRI scans. The amplitude of low‐frequency fluctuations (ALFF) and regional homogeneity (ReHo) assessed differences in spontaneous regional brain activity. Differences between the groups were selected as seeds for functional connectivity (FC) analyses. Correlations between disease duration and ALFF/ReHo/FC values in abnormal regions were analyzed. Results Patients with CD had significantly higher ALFF values in the left superior frontal gyrus, anterior cingulate cortex, and supplementary motor area, and lower values in the left hippocampus. They also had higher ReHo values in the left anterior cingulate cortex, supplementary motor area, putamen, and the bilateral superior frontal gyri. FC strength in the left precentral and middle temporal gyri was found to be increased when the left superior frontal gyrus was used as the seed point. FC strength was also observed to be increased in the left postcentral, middle frontal gyri, inferior frontal orbital cortex, and right rolandic operculum when the left anterior cingulate cortex was used as the seed point. Conclusion CD demonstrated abnormal neural activity and FC in various regions primarily associated with emotional, pain and cognitive‐related functions, which provides more information to further understand the neural mechanisms of the disease.https://doi.org/10.1002/brb3.2243amplitude of low‐frequency fluctuationsCrohn's diseasefunctional connectivityfunctional MRIregional homogeneity |
| spellingShingle | Lu Li Jie Ma Jian‐Guang Xu Yan‐Ling Zheng Qian Xie Lan Rong Zong‐Hui Liang Brain functional changes in patients with Crohn's disease: A resting‐state fMRI study Brain and Behavior amplitude of low‐frequency fluctuations Crohn's disease functional connectivity functional MRI regional homogeneity |
| title | Brain functional changes in patients with Crohn's disease: A resting‐state fMRI study |
| title_full | Brain functional changes in patients with Crohn's disease: A resting‐state fMRI study |
| title_fullStr | Brain functional changes in patients with Crohn's disease: A resting‐state fMRI study |
| title_full_unstemmed | Brain functional changes in patients with Crohn's disease: A resting‐state fMRI study |
| title_short | Brain functional changes in patients with Crohn's disease: A resting‐state fMRI study |
| title_sort | brain functional changes in patients with crohn s disease a resting state fmri study |
| topic | amplitude of low‐frequency fluctuations Crohn's disease functional connectivity functional MRI regional homogeneity |
| url | https://doi.org/10.1002/brb3.2243 |
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