Relationship among plasma vitamin B12 and folic acid levels and coronary artery disease
Background: Hyperhomocysteinemia is a new risk factor for cardiovascular disease. It is a sensitive marker of the vitamin B12 and folate insufficiency. Folate and vitamin B12 may be a protective effect on cardiovascular disease. According to limited data about role of vitamin B12 and folate in coron...
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| Format: | Article |
| Language: | English |
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Bushehr University of Medical Sciences
2012-04-01
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| Series: | Iranian South Medical Journal |
| Subjects: | |
| Online Access: | http://ismj.bpums.ac.ir/browse.php?a_code=A-10-3-251&slc_lang=en&sid=1 |
| _version_ | 1818964440574328832 |
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| author | Masoomeh Tohidhi Mohammad Hossein Dabbagh manesh Javad Kajouri Masoomeh Khedri |
| author_facet | Masoomeh Tohidhi Mohammad Hossein Dabbagh manesh Javad Kajouri Masoomeh Khedri |
| author_sort | Masoomeh Tohidhi |
| collection | DOAJ |
| description | Background: Hyperhomocysteinemia is a new risk factor for cardiovascular disease. It is a sensitive marker of the vitamin B12 and folate insufficiency. Folate and vitamin B12 may be a protective effect on cardiovascular disease. According to limited data about role of vitamin B12 and folate in coronary artery disease (CAD), we conducted this study to measure these factors in patients with coronary artery disease and in control subjects. Methods: This case-control study was performed on 139 subjects who underwent coronary angiography in Shiraz. Plasma vitamin B12 and folate level were measured and compared between patients with CAD and control subjects. Results: 139 individuals with a mean age 56.99±11.93 were enrolled in this study. 31.2% of them had a normal coronary angiography. Mean plasma level of folate in patients with CAD was lower than control subjects (4.46±1.28 ng/ml versus 5.00±1.81 ng/ml, P = 0.04). Also mean plasma level of vitamin B12 in patients CAD and control subjects were 451.43±138.90 and 503.60±199.35 pg/ml respectively. Although mean level of vitamin B12 in patients with CAD was lower than control group, but it was not statistically significant (P = 0.07). Conclusion: Mean plasma level of vitamin B12 and folate were lower in patients with CAD than control group. It seems that supplementation with this vitamins may be useful in patients with CAD. |
| first_indexed | 2024-12-20T13:01:09Z |
| format | Article |
| id | doaj.art-10ab797521a241fb849edd1f65ddd48e |
| institution | Directory Open Access Journal |
| issn | 1735-4374 1735-6954 |
| language | English |
| last_indexed | 2024-12-20T13:01:09Z |
| publishDate | 2012-04-01 |
| publisher | Bushehr University of Medical Sciences |
| record_format | Article |
| series | Iranian South Medical Journal |
| spelling | doaj.art-10ab797521a241fb849edd1f65ddd48e2022-12-21T19:39:54ZengBushehr University of Medical SciencesIranian South Medical Journal1735-43741735-69542012-04-011514350Relationship among plasma vitamin B12 and folic acid levels and coronary artery diseaseMasoomeh Tohidhi0Mohammad Hossein Dabbagh manesh1Javad Kajouri2Masoomeh Khedri3 Department of Endocrinology & Metabolism Research Center, Namazi Hospital, Shiraz University of Medical sciences, Fars, IRAN School of Medicine, Shiraz University of Medical sciences, Fars, IRAN School of Medicine, Ahvaz University of Medical sciences, Khoozestan, IRAN Background: Hyperhomocysteinemia is a new risk factor for cardiovascular disease. It is a sensitive marker of the vitamin B12 and folate insufficiency. Folate and vitamin B12 may be a protective effect on cardiovascular disease. According to limited data about role of vitamin B12 and folate in coronary artery disease (CAD), we conducted this study to measure these factors in patients with coronary artery disease and in control subjects. Methods: This case-control study was performed on 139 subjects who underwent coronary angiography in Shiraz. Plasma vitamin B12 and folate level were measured and compared between patients with CAD and control subjects. Results: 139 individuals with a mean age 56.99±11.93 were enrolled in this study. 31.2% of them had a normal coronary angiography. Mean plasma level of folate in patients with CAD was lower than control subjects (4.46±1.28 ng/ml versus 5.00±1.81 ng/ml, P = 0.04). Also mean plasma level of vitamin B12 in patients CAD and control subjects were 451.43±138.90 and 503.60±199.35 pg/ml respectively. Although mean level of vitamin B12 in patients with CAD was lower than control group, but it was not statistically significant (P = 0.07). Conclusion: Mean plasma level of vitamin B12 and folate were lower in patients with CAD than control group. It seems that supplementation with this vitamins may be useful in patients with CAD.http://ismj.bpums.ac.ir/browse.php?a_code=A-10-3-251&slc_lang=en&sid=1vitamin B12 folate coronary artery disease (CAD) homocystein |
| spellingShingle | Masoomeh Tohidhi Mohammad Hossein Dabbagh manesh Javad Kajouri Masoomeh Khedri Relationship among plasma vitamin B12 and folic acid levels and coronary artery disease Iranian South Medical Journal vitamin B12 folate coronary artery disease (CAD) homocystein |
| title | Relationship among plasma vitamin B12 and folic acid levels and coronary artery disease |
| title_full | Relationship among plasma vitamin B12 and folic acid levels and coronary artery disease |
| title_fullStr | Relationship among plasma vitamin B12 and folic acid levels and coronary artery disease |
| title_full_unstemmed | Relationship among plasma vitamin B12 and folic acid levels and coronary artery disease |
| title_short | Relationship among plasma vitamin B12 and folic acid levels and coronary artery disease |
| title_sort | relationship among plasma vitamin b12 and folic acid levels and coronary artery disease |
| topic | vitamin B12 folate coronary artery disease (CAD) homocystein |
| url | http://ismj.bpums.ac.ir/browse.php?a_code=A-10-3-251&slc_lang=en&sid=1 |
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