A Unique Case of IGF-2 Induced Hypoglycemia Associated with Hepatocellular Carcinoma
Tumor-induced hypoglycemia (TIH) associated with hepatocellular carcinoma (HCC) results from tumor production of insulin-like growth factor 2 (IGF-2), resulting in recurrent hypoglycemia. Serum levels of insulin-like growth factor 1 (IGF-1), insulin-like growth factor 2 (IGF-2), or pro-insulin-like...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2019-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2019/4601484 |
| _version_ | 1798045360230236160 |
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| author | Prachi Rana Brian Kim |
| author_facet | Prachi Rana Brian Kim |
| author_sort | Prachi Rana |
| collection | DOAJ |
| description | Tumor-induced hypoglycemia (TIH) associated with hepatocellular carcinoma (HCC) results from tumor production of insulin-like growth factor 2 (IGF-2), resulting in recurrent hypoglycemia. Serum levels of insulin-like growth factor 1 (IGF-1), insulin-like growth factor 2 (IGF-2), or pro-insulin-like growth factor 2 (pro-IGF-2) are required for the diagnosis. However, due to the limited availability of testing in many laboratories, this condition is often overlooked. As this condition is often overlooked, prompt recognition and implementation of tumor directed therapies and/or systemic therapies can help mitigate the consequences of hypoglycemia. We present a 38-year-old man with advanced multifocal HCC who presented with abdominal pain and was found to have recurrent symptomatic hypoglycemia. Evaluation revealed elevated levels of IGF-2, suggesting a diagnosis of HCC with production of IGF-2. |
| first_indexed | 2024-04-11T23:19:31Z |
| format | Article |
| id | doaj.art-10abfc0b658a417f8402bc34ba6dfba9 |
| institution | Directory Open Access Journal |
| issn | 2090-6501 2090-651X |
| language | English |
| last_indexed | 2024-04-11T23:19:31Z |
| publishDate | 2019-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj.art-10abfc0b658a417f8402bc34ba6dfba92022-12-22T03:57:30ZengHindawi LimitedCase Reports in Endocrinology2090-65012090-651X2019-01-01201910.1155/2019/46014844601484A Unique Case of IGF-2 Induced Hypoglycemia Associated with Hepatocellular CarcinomaPrachi Rana0Brian Kim1Department of Internal Medicine, Los Angeles County Hospital/University of Southern California, USADepartment of Gastroenterology and Liver Diseases, Los Angeles County Hospital/University of Southern California, USATumor-induced hypoglycemia (TIH) associated with hepatocellular carcinoma (HCC) results from tumor production of insulin-like growth factor 2 (IGF-2), resulting in recurrent hypoglycemia. Serum levels of insulin-like growth factor 1 (IGF-1), insulin-like growth factor 2 (IGF-2), or pro-insulin-like growth factor 2 (pro-IGF-2) are required for the diagnosis. However, due to the limited availability of testing in many laboratories, this condition is often overlooked. As this condition is often overlooked, prompt recognition and implementation of tumor directed therapies and/or systemic therapies can help mitigate the consequences of hypoglycemia. We present a 38-year-old man with advanced multifocal HCC who presented with abdominal pain and was found to have recurrent symptomatic hypoglycemia. Evaluation revealed elevated levels of IGF-2, suggesting a diagnosis of HCC with production of IGF-2.http://dx.doi.org/10.1155/2019/4601484 |
| spellingShingle | Prachi Rana Brian Kim A Unique Case of IGF-2 Induced Hypoglycemia Associated with Hepatocellular Carcinoma Case Reports in Endocrinology |
| title | A Unique Case of IGF-2 Induced Hypoglycemia Associated with Hepatocellular Carcinoma |
| title_full | A Unique Case of IGF-2 Induced Hypoglycemia Associated with Hepatocellular Carcinoma |
| title_fullStr | A Unique Case of IGF-2 Induced Hypoglycemia Associated with Hepatocellular Carcinoma |
| title_full_unstemmed | A Unique Case of IGF-2 Induced Hypoglycemia Associated with Hepatocellular Carcinoma |
| title_short | A Unique Case of IGF-2 Induced Hypoglycemia Associated with Hepatocellular Carcinoma |
| title_sort | unique case of igf 2 induced hypoglycemia associated with hepatocellular carcinoma |
| url | http://dx.doi.org/10.1155/2019/4601484 |
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