Associations between dog keeping and indoor dust microbiota
Abstract Living with dogs appears to protect against allergic diseases and airway infections, an effect possibly linked with immunomodulation by microbial exposures associated with dogs. The aim of this study was to characterize the influence of dog ownership on house dust microbiota composition. Th...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-84790-w |
| _version_ | 1818735844939268096 |
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| author | Jenni M. Mäki Pirkka V. Kirjavainen Martin Täubel Eija Piippo-Savolainen Katri Backman Anne Hyvärinen Pauli Tuoresmäki Balamuralikrishna Jayaprakash Joachim Heinrich Gunda Herberth Marie Standl Juha Pekkanen Anne M. Karvonen |
| author_facet | Jenni M. Mäki Pirkka V. Kirjavainen Martin Täubel Eija Piippo-Savolainen Katri Backman Anne Hyvärinen Pauli Tuoresmäki Balamuralikrishna Jayaprakash Joachim Heinrich Gunda Herberth Marie Standl Juha Pekkanen Anne M. Karvonen |
| author_sort | Jenni M. Mäki |
| collection | DOAJ |
| description | Abstract Living with dogs appears to protect against allergic diseases and airway infections, an effect possibly linked with immunomodulation by microbial exposures associated with dogs. The aim of this study was to characterize the influence of dog ownership on house dust microbiota composition. The bacterial and fungal microbiota was characterized with Illumina MiSeq sequencing from floor dust samples collected from homes in a Finnish rural-suburban (LUKAS2, N = 182) birth cohort, and the results were replicated in a German urban (LISA, N = 284) birth cohort. Human associated bacteria variable was created by summing up the relative abundances of five bacterial taxa. Bacterial richness, Shannon index and the relative abundances of seven bacterial genera, mostly within the phyla Proteobacteria and Firmicutes, were significantly higher in the dog than in the non-dog homes, whereas the relative abundance of human associated bacteria was lower. The results were largely replicated in LISA. Fungal microbiota richness and abundance of Leucosporidiella genus were higher in dog homes in LUKAS2 and the latter association replicated in LISA. Our study confirms that dog ownership is reproducibly associated with increased bacterial richness and diversity in house dust and identifies specific dog ownership-associated genera. Dogs appeared to have more limited influence on the fungal than bacterial indoor microbiota. |
| first_indexed | 2024-12-18T00:27:43Z |
| format | Article |
| id | doaj.art-10acb69b3c4d412b8741086c7218aa4f |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-18T00:27:43Z |
| publishDate | 2021-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-10acb69b3c4d412b8741086c7218aa4f2022-12-21T21:27:12ZengNature PortfolioScientific Reports2045-23222021-03-0111111110.1038/s41598-021-84790-wAssociations between dog keeping and indoor dust microbiotaJenni M. Mäki0Pirkka V. Kirjavainen1Martin Täubel2Eija Piippo-Savolainen3Katri Backman4Anne Hyvärinen5Pauli Tuoresmäki6Balamuralikrishna Jayaprakash7Joachim Heinrich8Gunda Herberth9Marie Standl10Juha Pekkanen11Anne M. Karvonen12Department of Health Security, Finnish Institute for Health and WelfareDepartment of Health Security, Finnish Institute for Health and WelfareDepartment of Health Security, Finnish Institute for Health and WelfareDepartment of Paediatrics, Kuopio University HospitalDepartment of Paediatrics, Kuopio University HospitalDepartment of Health Security, Finnish Institute for Health and WelfareDepartment of Health Security, Finnish Institute for Health and WelfareDepartment of Health Security, Finnish Institute for Health and WelfareInstitute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental HealthDepartment of Environmental Immunology/Core Facility Studies, Helmholtz Centre for Environmental Research – UFZInstitute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental HealthDepartment of Health Security, Finnish Institute for Health and WelfareDepartment of Health Security, Finnish Institute for Health and WelfareAbstract Living with dogs appears to protect against allergic diseases and airway infections, an effect possibly linked with immunomodulation by microbial exposures associated with dogs. The aim of this study was to characterize the influence of dog ownership on house dust microbiota composition. The bacterial and fungal microbiota was characterized with Illumina MiSeq sequencing from floor dust samples collected from homes in a Finnish rural-suburban (LUKAS2, N = 182) birth cohort, and the results were replicated in a German urban (LISA, N = 284) birth cohort. Human associated bacteria variable was created by summing up the relative abundances of five bacterial taxa. Bacterial richness, Shannon index and the relative abundances of seven bacterial genera, mostly within the phyla Proteobacteria and Firmicutes, were significantly higher in the dog than in the non-dog homes, whereas the relative abundance of human associated bacteria was lower. The results were largely replicated in LISA. Fungal microbiota richness and abundance of Leucosporidiella genus were higher in dog homes in LUKAS2 and the latter association replicated in LISA. Our study confirms that dog ownership is reproducibly associated with increased bacterial richness and diversity in house dust and identifies specific dog ownership-associated genera. Dogs appeared to have more limited influence on the fungal than bacterial indoor microbiota.https://doi.org/10.1038/s41598-021-84790-w |
| spellingShingle | Jenni M. Mäki Pirkka V. Kirjavainen Martin Täubel Eija Piippo-Savolainen Katri Backman Anne Hyvärinen Pauli Tuoresmäki Balamuralikrishna Jayaprakash Joachim Heinrich Gunda Herberth Marie Standl Juha Pekkanen Anne M. Karvonen Associations between dog keeping and indoor dust microbiota Scientific Reports |
| title | Associations between dog keeping and indoor dust microbiota |
| title_full | Associations between dog keeping and indoor dust microbiota |
| title_fullStr | Associations between dog keeping and indoor dust microbiota |
| title_full_unstemmed | Associations between dog keeping and indoor dust microbiota |
| title_short | Associations between dog keeping and indoor dust microbiota |
| title_sort | associations between dog keeping and indoor dust microbiota |
| url | https://doi.org/10.1038/s41598-021-84790-w |
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