Liposomal form of desferal as an effective chlamidial agent
Des f eral is a free iron ions blocker used for heart attacks and strokes treatment for more than 30 years. In several in vitro studies it was also shown that desferal concentrations of 15–100 mM cause shortage of iron in Chlamydia pneumoniae and Chlamydia trachomatis, affecting these bacteria growt...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
MIREA - Russian Technological University
2012-12-01
|
| Series: | Тонкие химические технологии |
| Subjects: | |
| Online Access: | https://www.finechem-mirea.ru/jour/article/view/669 |
| _version_ | 1797882088348712960 |
|---|---|
| author | N. V. Rukosueva D. A. Zakharova D. A. Bezrykov A. P. Kaplun V. I. Shvets N. A. Zigangirova |
| author_facet | N. V. Rukosueva D. A. Zakharova D. A. Bezrykov A. P. Kaplun V. I. Shvets N. A. Zigangirova |
| author_sort | N. V. Rukosueva |
| collection | DOAJ |
| description | Des f eral is a free iron ions blocker used for heart attacks and strokes treatment for more than 30 years. In several in vitro studies it was also shown that desferal concentrations of 15–100 mM cause shortage of iron in Chlamydia pneumoniae and Chlamydia trachomatis, affecting these bacteria growth and development. The main problems of this compound for treatment of chlamydia are its toxicity and low ability to pass through the cell membrane. In this research the in vitro toxicity and activity of desferal encapsulated in soybean phosphatidyl - choline liposomes were studied. It was demonstrated that the liposomal form of the chelator is less toxic and more active as compared to its solution. |
| first_indexed | 2024-04-10T03:30:29Z |
| format | Article |
| id | doaj.art-10b0359431614e5288afcf3ce54c0bd2 |
| institution | Directory Open Access Journal |
| issn | 2410-6593 2686-7575 |
| language | Russian |
| last_indexed | 2024-04-10T03:30:29Z |
| publishDate | 2012-12-01 |
| publisher | MIREA - Russian Technological University |
| record_format | Article |
| series | Тонкие химические технологии |
| spelling | doaj.art-10b0359431614e5288afcf3ce54c0bd22023-03-13T07:25:33ZrusMIREA - Russian Technological UniversityТонкие химические технологии2410-65932686-75752012-12-01762226663Liposomal form of desferal as an effective chlamidial agentN. V. Rukosueva0D. A. Zakharova1D. A. Bezrykov2A. P. Kaplun3V. I. Shvets4N. A. Zigangirova5M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571ГУ НИИ эпидемиологии и микробиологии им. Н.Ф. Гамалеи РАМНDes f eral is a free iron ions blocker used for heart attacks and strokes treatment for more than 30 years. In several in vitro studies it was also shown that desferal concentrations of 15–100 mM cause shortage of iron in Chlamydia pneumoniae and Chlamydia trachomatis, affecting these bacteria growth and development. The main problems of this compound for treatment of chlamydia are its toxicity and low ability to pass through the cell membrane. In this research the in vitro toxicity and activity of desferal encapsulated in soybean phosphatidyl - choline liposomes were studied. It was demonstrated that the liposomal form of the chelator is less toxic and more active as compared to its solution.https://www.finechem-mirea.ru/jour/article/view/669chlamydiosis, desferal, liposomes, cytotoxicity. |
| spellingShingle | N. V. Rukosueva D. A. Zakharova D. A. Bezrykov A. P. Kaplun V. I. Shvets N. A. Zigangirova Liposomal form of desferal as an effective chlamidial agent Тонкие химические технологии chlamydiosis, desferal, liposomes, cytotoxicity. |
| title | Liposomal form of desferal as an effective chlamidial agent |
| title_full | Liposomal form of desferal as an effective chlamidial agent |
| title_fullStr | Liposomal form of desferal as an effective chlamidial agent |
| title_full_unstemmed | Liposomal form of desferal as an effective chlamidial agent |
| title_short | Liposomal form of desferal as an effective chlamidial agent |
| title_sort | liposomal form of desferal as an effective chlamidial agent |
| topic | chlamydiosis, desferal, liposomes, cytotoxicity. |
| url | https://www.finechem-mirea.ru/jour/article/view/669 |
| work_keys_str_mv | AT nvrukosueva liposomalformofdesferalasaneffectivechlamidialagent AT dazakharova liposomalformofdesferalasaneffectivechlamidialagent AT dabezrykov liposomalformofdesferalasaneffectivechlamidialagent AT apkaplun liposomalformofdesferalasaneffectivechlamidialagent AT vishvets liposomalformofdesferalasaneffectivechlamidialagent AT nazigangirova liposomalformofdesferalasaneffectivechlamidialagent |