Allele Frequencies and Forensic Data of 25 STR Markers for Individuals in Northeast Brazil
Identifying DNA markers such as Short Tandem Repeats (STR) can be used to investigate genetic diversity based on levels of heterozygosity within and between populations. Allele frequencies and forensic data for STRs were obtained from a sample of 384 unrelated individuals living in Bahia, Northeaste...
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| Format: | Article |
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MDPI AG
2023-05-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/14/6/1185 |
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| author | Natalia Bahia Pinheiro dos Santos Márcio Fabrício Falcão de Paula Filho Abigail Marcelino dos Santos Silva Enio Paulo Teló José Bandeira do Nascimento Junior Valdir de Queiroz Balbino Iukary Oliveira Takenami Isaac Farias Cansanção |
| author_facet | Natalia Bahia Pinheiro dos Santos Márcio Fabrício Falcão de Paula Filho Abigail Marcelino dos Santos Silva Enio Paulo Teló José Bandeira do Nascimento Junior Valdir de Queiroz Balbino Iukary Oliveira Takenami Isaac Farias Cansanção |
| author_sort | Natalia Bahia Pinheiro dos Santos |
| collection | DOAJ |
| description | Identifying DNA markers such as Short Tandem Repeats (STR) can be used to investigate genetic diversity based on levels of heterozygosity within and between populations. Allele frequencies and forensic data for STRs were obtained from a sample of 384 unrelated individuals living in Bahia, Northeastern Brazil. Thus, the present study aimed to identify the allele frequency distribution, in addition to the forensic and genetic data, of 25 STR loci in the population of Bahia. Buccal swabs or fingertip punctures were utilized to amplify and detect 25 DNA markers. The most polymorphic loci were SE33 (43), D21S11, and FGA (21). The least polymorphic were TH01 (6), TPOX, and D3S1358 (7). Forensic and statistical data were obtained through data analysis, which revealed a large genetic diversity, with an average value of 0.813 for the analyzed population. The present study was more robust than previous STR marker studies and will contribute to future research on population genetics in Brazil and worldwide. The results of this study allowed the establishment of haplotypes found in the forensic samples of Bahia State to serve as a reference in the elucidation of criminal cases and paternity tests, as well as population and evolutionary investigations. |
| first_indexed | 2024-03-11T02:25:04Z |
| format | Article |
| id | doaj.art-10b3bdb44f834fc8a16769d1b8c21297 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-11T02:25:04Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-10b3bdb44f834fc8a16769d1b8c212972023-11-18T10:33:59ZengMDPI AGGenes2073-44252023-05-01146118510.3390/genes14061185Allele Frequencies and Forensic Data of 25 STR Markers for Individuals in Northeast BrazilNatalia Bahia Pinheiro dos Santos0Márcio Fabrício Falcão de Paula Filho1Abigail Marcelino dos Santos Silva2Enio Paulo Teló3José Bandeira do Nascimento Junior4Valdir de Queiroz Balbino5Iukary Oliveira Takenami6Isaac Farias Cansanção7Escola de Ciências da Saúde, Universidade Salvador, Salvador 41720-200, BA, BrazilMedicine Collegiate, Campus Paulo Afonso, Federal University of San Francisco Valley (UNIVASF), Amizade Avenue, 1900, Paulo Afonso 48605-780, BA, BrazilLaboratory of Bioinformatics and Evolutionary Biology, Department of Genetics, Federal University of Pernambuco, Recife 50740-580, PE, BrazilLaboratório de Investigação do Vínculo Genético, Centro de Diagnóstico do GACC (CDG), Grupo de Apoio à Criança com Câncer (GACC), Salvador 41250-010, BA, BrazilLaboratory of Bioinformatics and Evolutionary Biology, Department of Genetics, Federal University of Pernambuco, Recife 50740-580, PE, BrazilLaboratory of Bioinformatics and Evolutionary Biology, Department of Genetics, Federal University of Pernambuco, Recife 50740-580, PE, BrazilMedicine Collegiate, Campus Paulo Afonso, Federal University of San Francisco Valley (UNIVASF), Amizade Avenue, 1900, Paulo Afonso 48605-780, BA, BrazilMedicine Collegiate, Campus Paulo Afonso, Federal University of San Francisco Valley (UNIVASF), Amizade Avenue, 1900, Paulo Afonso 48605-780, BA, BrazilIdentifying DNA markers such as Short Tandem Repeats (STR) can be used to investigate genetic diversity based on levels of heterozygosity within and between populations. Allele frequencies and forensic data for STRs were obtained from a sample of 384 unrelated individuals living in Bahia, Northeastern Brazil. Thus, the present study aimed to identify the allele frequency distribution, in addition to the forensic and genetic data, of 25 STR loci in the population of Bahia. Buccal swabs or fingertip punctures were utilized to amplify and detect 25 DNA markers. The most polymorphic loci were SE33 (43), D21S11, and FGA (21). The least polymorphic were TH01 (6), TPOX, and D3S1358 (7). Forensic and statistical data were obtained through data analysis, which revealed a large genetic diversity, with an average value of 0.813 for the analyzed population. The present study was more robust than previous STR marker studies and will contribute to future research on population genetics in Brazil and worldwide. The results of this study allowed the establishment of haplotypes found in the forensic samples of Bahia State to serve as a reference in the elucidation of criminal cases and paternity tests, as well as population and evolutionary investigations.https://www.mdpi.com/2073-4425/14/6/1185medical and population geneticsstatistical genetics and genomicsshort tandem repeatsallele frequenciesBrazilian population |
| spellingShingle | Natalia Bahia Pinheiro dos Santos Márcio Fabrício Falcão de Paula Filho Abigail Marcelino dos Santos Silva Enio Paulo Teló José Bandeira do Nascimento Junior Valdir de Queiroz Balbino Iukary Oliveira Takenami Isaac Farias Cansanção Allele Frequencies and Forensic Data of 25 STR Markers for Individuals in Northeast Brazil Genes medical and population genetics statistical genetics and genomics short tandem repeats allele frequencies Brazilian population |
| title | Allele Frequencies and Forensic Data of 25 STR Markers for Individuals in Northeast Brazil |
| title_full | Allele Frequencies and Forensic Data of 25 STR Markers for Individuals in Northeast Brazil |
| title_fullStr | Allele Frequencies and Forensic Data of 25 STR Markers for Individuals in Northeast Brazil |
| title_full_unstemmed | Allele Frequencies and Forensic Data of 25 STR Markers for Individuals in Northeast Brazil |
| title_short | Allele Frequencies and Forensic Data of 25 STR Markers for Individuals in Northeast Brazil |
| title_sort | allele frequencies and forensic data of 25 str markers for individuals in northeast brazil |
| topic | medical and population genetics statistical genetics and genomics short tandem repeats allele frequencies Brazilian population |
| url | https://www.mdpi.com/2073-4425/14/6/1185 |
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