A MicroRNA Cluster in the DLK1-DIO3 Imprinted Region on Chromosome 14q32.2 Is Dysregulated in Metastatic Hepatoblastomas

A MicroRNA Cluster in the DLK1-DIO3 Imprinted Region on Chromosome 14q32.2 Is Dysregulated in Metastatic Hepatoblastomas

Hepatoblastoma (HB) is the most common malignant liver neoplasm in children. Despite progress in HB therapy, outcomes for patients with metastatic disease remain poor. Dysregulation of miRNA expression is one of the potential epigenetic mechanisms associated with pathogenesis of HB. However, miRNA p...

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Bibliographic Details
Main Authors: Shohei Honda, Aniruddha Chatterjee, Anna L. Leichter, Hisayuki Miyagi, Masashi Minato, Sunao Fujiyoshi, Momoko Ara, Norihiko Kitagawa, Mio Tanaka, Yukichi Tanaka, Masato Shinkai, Kanako C. Hatanaka, Akinobu Taketomi, Michael R. Eccles
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Oncology
Subjects:
epigenetics
small nucleolar RNAs
microRNAs
hepatoblastoma
14q32-encoded imprinted cluster genes
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.513601/full

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