Low MSP-1 haplotype diversity in the West Palearctic population of the avian malaria parasite Plasmodium relictum
Abstract Background Although avian Plasmodium species are widespread and common across the globe, limited data exist on how genetically variable their populations are. Here, the hypothesis that the avian blood parasite Plasmodium relictum exhibits very low genetic diversity in its Western Palearctic...
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| Format: | Article |
| Language: | English |
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BMC
2021-06-01
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| Series: | Malaria Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12936-021-03799-8 |
| _version_ | 1819088825877528576 |
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| author | Olof Hellgren Victor Kelbskopf Vincenzo A. Ellis Arif Ciloglu Mélanie Duc Xi Huang Ricardo J. Lopes Vanessa A. Mata Sargis A. Aghayan Abdullah Inci Sergei V. Drovetski |
| author_facet | Olof Hellgren Victor Kelbskopf Vincenzo A. Ellis Arif Ciloglu Mélanie Duc Xi Huang Ricardo J. Lopes Vanessa A. Mata Sargis A. Aghayan Abdullah Inci Sergei V. Drovetski |
| author_sort | Olof Hellgren |
| collection | DOAJ |
| description | Abstract Background Although avian Plasmodium species are widespread and common across the globe, limited data exist on how genetically variable their populations are. Here, the hypothesis that the avian blood parasite Plasmodium relictum exhibits very low genetic diversity in its Western Palearctic transmission area (from Morocco to Sweden in the north and Transcaucasia in the east) was tested. Methods The genetic diversity of Plasmodium relictum was investigated by sequencing a portion (block 14) of the fast-evolving merozoite surface protein 1 (MSP1) gene in 75 different P. relictum infections from 36 host species. Furthermore, the full-length MSP1 sequences representing the common block 14 allele was sequenced in order to investigate if additional variation could be found outside block 14. Results The majority (72 of 75) of the sequenced infections shared the same MSP1 allele. This common allele has previously been found to be the dominant allele transmitted in Europe. Conclusion The results corroborate earlier findings derived from a limited dataset that the globally transmitted malaria parasite P. relictum exhibits very low genetic diversity in its Western Palearctic transmission area. This is likely the result of a recent introduction event or a selective sweep. |
| first_indexed | 2024-12-21T21:58:12Z |
| format | Article |
| id | doaj.art-10b3e94cd807400da45c535f9ce3ad63 |
| institution | Directory Open Access Journal |
| issn | 1475-2875 |
| language | English |
| last_indexed | 2024-12-21T21:58:12Z |
| publishDate | 2021-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Malaria Journal |
| spelling | doaj.art-10b3e94cd807400da45c535f9ce3ad632022-12-21T18:48:54ZengBMCMalaria Journal1475-28752021-06-012011910.1186/s12936-021-03799-8Low MSP-1 haplotype diversity in the West Palearctic population of the avian malaria parasite Plasmodium relictumOlof Hellgren0Victor Kelbskopf1Vincenzo A. Ellis2Arif Ciloglu3Mélanie Duc4Xi Huang5Ricardo J. Lopes6Vanessa A. Mata7Sargis A. Aghayan8Abdullah Inci9Sergei V. Drovetski10Department of Biology, Lund UniversityDepartment of Biology, Lund UniversityDepartment of Biology, Lund UniversityDepartment of Biology, Lund UniversityDepartment of Biology, Lund UniversityDepartment of Biology, Lund UniversityCIBIO, Centro de Investigação Em Biodiversidade E Recursos Genéticos, InBIO Laboratório Associado, Universidade Do PortoCIBIO, Centro de Investigação Em Biodiversidade E Recursos Genéticos, InBIO Laboratório Associado, Universidade Do PortoYerevan State UniversityDepartment of Parasitology, Faculty of Veterinary Medicine, Erciyes UniversityUS Geological Survey, Eastern Ecological Research Center at Patuxent Research RefugeAbstract Background Although avian Plasmodium species are widespread and common across the globe, limited data exist on how genetically variable their populations are. Here, the hypothesis that the avian blood parasite Plasmodium relictum exhibits very low genetic diversity in its Western Palearctic transmission area (from Morocco to Sweden in the north and Transcaucasia in the east) was tested. Methods The genetic diversity of Plasmodium relictum was investigated by sequencing a portion (block 14) of the fast-evolving merozoite surface protein 1 (MSP1) gene in 75 different P. relictum infections from 36 host species. Furthermore, the full-length MSP1 sequences representing the common block 14 allele was sequenced in order to investigate if additional variation could be found outside block 14. Results The majority (72 of 75) of the sequenced infections shared the same MSP1 allele. This common allele has previously been found to be the dominant allele transmitted in Europe. Conclusion The results corroborate earlier findings derived from a limited dataset that the globally transmitted malaria parasite P. relictum exhibits very low genetic diversity in its Western Palearctic transmission area. This is likely the result of a recent introduction event or a selective sweep.https://doi.org/10.1186/s12936-021-03799-8Avian malariaHaemosporidaHost specificityMerozoite surface protein 1Parasite population structurePlasmodium relictum |
| spellingShingle | Olof Hellgren Victor Kelbskopf Vincenzo A. Ellis Arif Ciloglu Mélanie Duc Xi Huang Ricardo J. Lopes Vanessa A. Mata Sargis A. Aghayan Abdullah Inci Sergei V. Drovetski Low MSP-1 haplotype diversity in the West Palearctic population of the avian malaria parasite Plasmodium relictum Malaria Journal Avian malaria Haemosporida Host specificity Merozoite surface protein 1 Parasite population structure Plasmodium relictum |
| title | Low MSP-1 haplotype diversity in the West Palearctic population of the avian malaria parasite Plasmodium relictum |
| title_full | Low MSP-1 haplotype diversity in the West Palearctic population of the avian malaria parasite Plasmodium relictum |
| title_fullStr | Low MSP-1 haplotype diversity in the West Palearctic population of the avian malaria parasite Plasmodium relictum |
| title_full_unstemmed | Low MSP-1 haplotype diversity in the West Palearctic population of the avian malaria parasite Plasmodium relictum |
| title_short | Low MSP-1 haplotype diversity in the West Palearctic population of the avian malaria parasite Plasmodium relictum |
| title_sort | low msp 1 haplotype diversity in the west palearctic population of the avian malaria parasite plasmodium relictum |
| topic | Avian malaria Haemosporida Host specificity Merozoite surface protein 1 Parasite population structure Plasmodium relictum |
| url | https://doi.org/10.1186/s12936-021-03799-8 |
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