Neutrophil stimulation with citrullinated histone H4 slows down calcium influx and reduces NET formation compared with native histone H4.
Peptidylarginine deiminase 4 (PAD4) catalyzes posttranslational modification of many target proteins through converting protein arginine or mono-methylarginine to citrulline. Neutrophil extracellular trap (NET) formation is the most dramatic manifestation of PAD4-mediated hypercitrullination reactio...
| Główni autorzy: | , , |
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| Format: | Artykuł |
| Język: | English |
| Wydane: |
Public Library of Science (PLoS)
2021-01-01
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| Seria: | PLoS ONE |
| Dostęp online: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0251726&type=printable |