Landscape of CDKN1B Mutations in Luminal Breast Cancer and Other Hormone-Driven Human Tumors

Landscape of CDKN1B Mutations in Luminal Breast Cancer and Other Hormone-Driven Human Tumors

The CDKN1B gene encodes for the p27Kip1 protein, firstly characterized as a cyclin dependent kinase (CDK)-inhibitor. Germline CDKN1B pathogenic variants have been described in hereditary tumors, such as multiple endocrine neoplasia (MEN)-like syndromes and familial prostate cancer. Despite its centr...

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Bibliographic Details
Main Authors: Martina Cusan, Giorgia Mungo, Mara De Marco Zompit, Ilenia Segatto, Barbara Belletti, Gustavo Baldassarre
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Endocrinology
Subjects:
p27Kip1 protein
CDKN1B gene
somatic mutation
germinal mutation
driver mutation
passenger mutation
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2018.00393/full

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https://www.frontiersin.org/article/10.3389/fendo.2018.00393/full

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