Sleep Polygenic Risk Score Is Associated with Cognitive Changes over Time
Sleep problems have been associated with cognition, both cross-sectionally and longitudinally. Specific genes have been also associated with both sleep regulation and cognition. In a large group of older non-demented adults, we aimed to (a) validate the association between Sleep Polygenic Risk Score...
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MDPI AG
2021-12-01
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| Online Access: | https://www.mdpi.com/2073-4425/13/1/63 |
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| author | Angeliki Tsapanou Niki Mourtzi Sokratis Charisis Alex Hatzimanolis Eva Ntanasi Mary H. Kosmidis Mary Yannakoulia Georgios Hadjigeorgiou Efthimios Dardiotis Paraskevi Sakka Yaakov Stern Nikolaos Scarmeas |
| author_facet | Angeliki Tsapanou Niki Mourtzi Sokratis Charisis Alex Hatzimanolis Eva Ntanasi Mary H. Kosmidis Mary Yannakoulia Georgios Hadjigeorgiou Efthimios Dardiotis Paraskevi Sakka Yaakov Stern Nikolaos Scarmeas |
| author_sort | Angeliki Tsapanou |
| collection | DOAJ |
| description | Sleep problems have been associated with cognition, both cross-sectionally and longitudinally. Specific genes have been also associated with both sleep regulation and cognition. In a large group of older non-demented adults, we aimed to (a) validate the association between Sleep Polygenic Risk Score (Sleep PRS) and self-reported sleep duration, and (b) examine the association between Sleep PRS and cognitive changes in a three-year follow-up. Participants were drawn from the Hellenic Longitudinal Investigation of Aging and Diet (HELIAD). A structured, in-person interview, consisting of a medical history report and physical examination, was conducted for each participant during each of the visits (baseline and first follow-up). In total, 1376 participants were included, having all demographic, genetic, and cognitive data, out of which, 688 had at least one follow-up visit. In addition, an extensive neuropsychological assessment examining five cognitive domains (memory, visuo-spatial ability, attention/speed of processing, executive function, and language) was administered. A PRS for sleep duration was created based on previously published, genome-wide association study meta-analysis results. In order to assess the relationship between the Sleep PRS and the rate of cognitive change, we used generalized estimating equations analyses. Age, sex, education, <i>ApolipoproteinE-ε4</i> genotype status, and specific principal components were used as covariates. On a further analysis, sleep medication was used as a further covariate. Results validated the association between Sleep PRS and self-reported sleep duration (B = 1.173, E-6, <i>p</i> = 0.001). Further, in the longitudinal analyses, significant associations were indicated between increased Sleep PRS and decreased visuo-spatial ability trajectories, in both the unadjusted (B = −1305.220, <i>p</i> = 0.018) and the adjusted for the covariates model (B = −1273.59, <i>p</i> = 0.031). Similarly, after adding sleep medication as a covariate (B = −1372.46, <i>p</i> = 0.019), none of the associations between Sleep PRS and the remaining cognitive domains were significant. PRS indicating longer sleep duration was associated with differential rates of cognitive decline over time in a group of non-demented older adults. Common genetic variants may influence the association between sleep duration and healthy aging/cognitive health. |
| first_indexed | 2024-03-10T01:25:29Z |
| format | Article |
| id | doaj.art-10b6d0430f5642c5a2129875e7d927a2 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-10T01:25:29Z |
| publishDate | 2021-12-01 |
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| series | Genes |
| spelling | doaj.art-10b6d0430f5642c5a2129875e7d927a22023-11-23T13:51:44ZengMDPI AGGenes2073-44252021-12-011316310.3390/genes13010063Sleep Polygenic Risk Score Is Associated with Cognitive Changes over TimeAngeliki Tsapanou0Niki Mourtzi1Sokratis Charisis2Alex Hatzimanolis3Eva Ntanasi4Mary H. Kosmidis5Mary Yannakoulia6Georgios Hadjigeorgiou7Efthimios Dardiotis8Paraskevi Sakka9Yaakov Stern10Nikolaos Scarmeas11Columbia University Irving Medical Center, Cognitive Neuroscience Division, New York, NY 10032, USA1st Neurology Clinic, Department of Social Medicine, Psychiatry and Neurology, Eginition Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece1st Neurology Clinic, Department of Social Medicine, Psychiatry and Neurology, Eginition Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece1st Neurology Clinic, Department of Social Medicine, Psychiatry and Neurology, Eginition Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece1st Neurology Clinic, Department of Social Medicine, Psychiatry and Neurology, Eginition Hospital, National and Kapodistrian University of Athens, 11528 Athens, GreeceLaboratory of Cognitive Neuroscience, School of Psychology, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceDepartment of Nutrition and Dietetics, Harokopio University, 17671 Athens, GreeceSchool of Medicine, University of Thessaly, 41334 Larissa, GreeceSchool of Medicine, University of Thessaly, 41334 Larissa, GreeceAthens Alzheimer’s Association, 11636 Athens, GreeceColumbia University Irving Medical Center, Cognitive Neuroscience Division, New York, NY 10032, USALaboratory of Cognitive Neuroscience, School of Psychology, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceSleep problems have been associated with cognition, both cross-sectionally and longitudinally. Specific genes have been also associated with both sleep regulation and cognition. In a large group of older non-demented adults, we aimed to (a) validate the association between Sleep Polygenic Risk Score (Sleep PRS) and self-reported sleep duration, and (b) examine the association between Sleep PRS and cognitive changes in a three-year follow-up. Participants were drawn from the Hellenic Longitudinal Investigation of Aging and Diet (HELIAD). A structured, in-person interview, consisting of a medical history report and physical examination, was conducted for each participant during each of the visits (baseline and first follow-up). In total, 1376 participants were included, having all demographic, genetic, and cognitive data, out of which, 688 had at least one follow-up visit. In addition, an extensive neuropsychological assessment examining five cognitive domains (memory, visuo-spatial ability, attention/speed of processing, executive function, and language) was administered. A PRS for sleep duration was created based on previously published, genome-wide association study meta-analysis results. In order to assess the relationship between the Sleep PRS and the rate of cognitive change, we used generalized estimating equations analyses. Age, sex, education, <i>ApolipoproteinE-ε4</i> genotype status, and specific principal components were used as covariates. On a further analysis, sleep medication was used as a further covariate. Results validated the association between Sleep PRS and self-reported sleep duration (B = 1.173, E-6, <i>p</i> = 0.001). Further, in the longitudinal analyses, significant associations were indicated between increased Sleep PRS and decreased visuo-spatial ability trajectories, in both the unadjusted (B = −1305.220, <i>p</i> = 0.018) and the adjusted for the covariates model (B = −1273.59, <i>p</i> = 0.031). Similarly, after adding sleep medication as a covariate (B = −1372.46, <i>p</i> = 0.019), none of the associations between Sleep PRS and the remaining cognitive domains were significant. PRS indicating longer sleep duration was associated with differential rates of cognitive decline over time in a group of non-demented older adults. Common genetic variants may influence the association between sleep duration and healthy aging/cognitive health.https://www.mdpi.com/2073-4425/13/1/63sleeppolygenic risk scorecognition |
| spellingShingle | Angeliki Tsapanou Niki Mourtzi Sokratis Charisis Alex Hatzimanolis Eva Ntanasi Mary H. Kosmidis Mary Yannakoulia Georgios Hadjigeorgiou Efthimios Dardiotis Paraskevi Sakka Yaakov Stern Nikolaos Scarmeas Sleep Polygenic Risk Score Is Associated with Cognitive Changes over Time Genes sleep polygenic risk score cognition |
| title | Sleep Polygenic Risk Score Is Associated with Cognitive Changes over Time |
| title_full | Sleep Polygenic Risk Score Is Associated with Cognitive Changes over Time |
| title_fullStr | Sleep Polygenic Risk Score Is Associated with Cognitive Changes over Time |
| title_full_unstemmed | Sleep Polygenic Risk Score Is Associated with Cognitive Changes over Time |
| title_short | Sleep Polygenic Risk Score Is Associated with Cognitive Changes over Time |
| title_sort | sleep polygenic risk score is associated with cognitive changes over time |
| topic | sleep polygenic risk score cognition |
| url | https://www.mdpi.com/2073-4425/13/1/63 |
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