Inulin and Fibersol-2 Combined Have Hypolipidemic Effects on High Cholesterol Diet-Induced Hyperlipidemia in Hamsters
The resistant carbohydrates, inulin, and Fibersol-2, belong to soluble dietary fibers and are considered important prebiotics that maintain biological functions, including glucose homeostasis, lipid regulation, colon disease prevention, and prebiotics characteristics. However, few studies have inves...
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| Format: | Article |
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MDPI AG
2016-03-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/21/3/313 |
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| author | Wen-Ching Huang Che-Li Lin Yi-Ju Hsu Yen-Shuo Chiu Yi-Ming Chen Ming-Fang Wu Chi-Chang Huang Ming-Fu Wang |
| author_facet | Wen-Ching Huang Che-Li Lin Yi-Ju Hsu Yen-Shuo Chiu Yi-Ming Chen Ming-Fang Wu Chi-Chang Huang Ming-Fu Wang |
| author_sort | Wen-Ching Huang |
| collection | DOAJ |
| description | The resistant carbohydrates, inulin, and Fibersol-2, belong to soluble dietary fibers and are considered important prebiotics that maintain biological functions, including glucose homeostasis, lipid regulation, colon disease prevention, and prebiotics characteristics. However, few studies have investigated Fibersol-2 alone or in combination with inulin to assess a pooled effect on modulation of hyperlipidemia. We aimed to investigate the effects of this combined supplement (defined as InF) on hamsters fed a 0.2% cholesterol and 10% lard diet (i.e., high-cholesterol diet, HCD) to induce hyperlipidemia. A total of 40 male hamsters were randomly assigned to five groups (n = 8 per group) for treatment: standard diet, vehicle (control); or vehicle or InF supplementation by oral gavage at 0, 864, 1727, or 2591 mg/kg/day for eight weeks, designated HCD, InF-1X, InF-2X, and InF-3X groups, respectively. The hypolipidemic efficacy and safety of InF supplementation was assessed by serum lipid indexes, hepatic and fecal lipid content, and histology. InF supplementation significantly improved serum levels of triacylglycerol (TG) and low-density lipoprotein cholesterol (LDL-C) and the ratio of LDL-C/HDL-C after two-week treatment, and reduced serum total cholesterol (TC) levels after four-week administration. After eight-week supplementation, InF supplementation dose-dependently improved serum levels of TC, TG, HDL-C, and LDL-C; LDL-C/HDL-C ratio; and hepatic TC and TG levels. It inhibited TC absorption by feces elimination. Our study provides experiment-based evidence to support that this prebiotics remedy may be useful in preventing or treating hyperlipidemia. |
| first_indexed | 2024-12-20T15:03:09Z |
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| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-20T15:03:09Z |
| publishDate | 2016-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-10b753fac77a4459b419dc11dc0bbaad2022-12-21T19:36:35ZengMDPI AGMolecules1420-30492016-03-0121331310.3390/molecules21030313molecules21030313Inulin and Fibersol-2 Combined Have Hypolipidemic Effects on High Cholesterol Diet-Induced Hyperlipidemia in HamstersWen-Ching Huang0Che-Li Lin1Yi-Ju Hsu2Yen-Shuo Chiu3Yi-Ming Chen4Ming-Fang Wu5Chi-Chang Huang6Ming-Fu Wang7Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan City 33301, TaiwanGraduate Institute of Sports Science, National Taiwan Sport University, Taoyuan City 33301, TaiwanGraduate Institute of Sports Science, National Taiwan Sport University, Taoyuan City 33301, TaiwanGraduate Institute of Sports Science, National Taiwan Sport University, Taoyuan City 33301, TaiwanGraduate Institute of Sports Science, National Taiwan Sport University, Taoyuan City 33301, TaiwanZ-Plus Biotechnology Co., Ltd., Hami St., Datong Dist., Taipei City 10367, TaiwanGraduate Institute of Sports Science, National Taiwan Sport University, Taoyuan City 33301, TaiwanDepartment of Food and Nutrition, Providence University, Taichung City 43301, TaiwanThe resistant carbohydrates, inulin, and Fibersol-2, belong to soluble dietary fibers and are considered important prebiotics that maintain biological functions, including glucose homeostasis, lipid regulation, colon disease prevention, and prebiotics characteristics. However, few studies have investigated Fibersol-2 alone or in combination with inulin to assess a pooled effect on modulation of hyperlipidemia. We aimed to investigate the effects of this combined supplement (defined as InF) on hamsters fed a 0.2% cholesterol and 10% lard diet (i.e., high-cholesterol diet, HCD) to induce hyperlipidemia. A total of 40 male hamsters were randomly assigned to five groups (n = 8 per group) for treatment: standard diet, vehicle (control); or vehicle or InF supplementation by oral gavage at 0, 864, 1727, or 2591 mg/kg/day for eight weeks, designated HCD, InF-1X, InF-2X, and InF-3X groups, respectively. The hypolipidemic efficacy and safety of InF supplementation was assessed by serum lipid indexes, hepatic and fecal lipid content, and histology. InF supplementation significantly improved serum levels of triacylglycerol (TG) and low-density lipoprotein cholesterol (LDL-C) and the ratio of LDL-C/HDL-C after two-week treatment, and reduced serum total cholesterol (TC) levels after four-week administration. After eight-week supplementation, InF supplementation dose-dependently improved serum levels of TC, TG, HDL-C, and LDL-C; LDL-C/HDL-C ratio; and hepatic TC and TG levels. It inhibited TC absorption by feces elimination. Our study provides experiment-based evidence to support that this prebiotics remedy may be useful in preventing or treating hyperlipidemia.http://www.mdpi.com/1420-3049/21/3/313hypolipidemicinulinresistant maltodextrinhigh-cholesterol dietlipid-profiles |
| spellingShingle | Wen-Ching Huang Che-Li Lin Yi-Ju Hsu Yen-Shuo Chiu Yi-Ming Chen Ming-Fang Wu Chi-Chang Huang Ming-Fu Wang Inulin and Fibersol-2 Combined Have Hypolipidemic Effects on High Cholesterol Diet-Induced Hyperlipidemia in Hamsters Molecules hypolipidemic inulin resistant maltodextrin high-cholesterol diet lipid-profiles |
| title | Inulin and Fibersol-2 Combined Have Hypolipidemic Effects on High Cholesterol Diet-Induced Hyperlipidemia in Hamsters |
| title_full | Inulin and Fibersol-2 Combined Have Hypolipidemic Effects on High Cholesterol Diet-Induced Hyperlipidemia in Hamsters |
| title_fullStr | Inulin and Fibersol-2 Combined Have Hypolipidemic Effects on High Cholesterol Diet-Induced Hyperlipidemia in Hamsters |
| title_full_unstemmed | Inulin and Fibersol-2 Combined Have Hypolipidemic Effects on High Cholesterol Diet-Induced Hyperlipidemia in Hamsters |
| title_short | Inulin and Fibersol-2 Combined Have Hypolipidemic Effects on High Cholesterol Diet-Induced Hyperlipidemia in Hamsters |
| title_sort | inulin and fibersol 2 combined have hypolipidemic effects on high cholesterol diet induced hyperlipidemia in hamsters |
| topic | hypolipidemic inulin resistant maltodextrin high-cholesterol diet lipid-profiles |
| url | http://www.mdpi.com/1420-3049/21/3/313 |
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