Compensation for PKMζ in long-term potentiation and spatial long-term memory in mutant mice

Compensation for PKMζ in long-term potentiation and spatial long-term memory in mutant mice

PKMζ is a persistently active PKC isoform proposed to maintain late-LTP and long-term memory. But late-LTP and memory are maintained without PKMζ in PKMζ-null mice. Two hypotheses can account for these findings. First, PKMζ is unimportant for LTP or memory. Second, PKMζ is essential for late-LTP and...

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Bibliographic Details
Main Authors: Panayiotis Tsokas, Changchi Hsieh, Yudong Yao, Edith Lesburguères, Emma Jane Claire Wallace, Andrew Tcherepanov, Desingarao Jothianandan, Benjamin Rush Hartley, Ling Pan, Bruno Rivard, Robert V Farese, Mini P Sajan, Peter John Bergold, Alejandro Iván Hernández, James E Cottrell, Harel Z Shouval, André Antonio Fenton, Todd Charlton Sacktor
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-05-01
Series:eLife
Subjects:
atypical PKC
memory
PKM-zeta
LTP
PKMzeta
PKCiota/lambda
Online Access:https://elifesciences.org/articles/14846

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