LPS Promotes Vascular Smooth Muscle Cells Proliferation Through the TLR4/Rac1/Akt Signalling Pathway

LPS Promotes Vascular Smooth Muscle Cells Proliferation Through the TLR4/Rac1/Akt Signalling Pathway

Background/Aims: Lipopolysaccharide (LPS) is a potent activator of vascular smooth muscle cells (VSMCs) proliferation, but the underlying mechanism remains unknown. In this study, we knocked down Toll-like receptor 4 (TLR4) and Ras-related C3 botulinum toxin substrate 1 (Rac1) expression using small...

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Bibliographic Details
Main Authors: Qianran Yin, Dehua Jiang, Lei Li, Yu Yang, Pei wu, Yuanyuan Luo, Rongli Yang, Dongye Li
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-12-01
Series:Cellular Physiology and Biochemistry
Subjects:
Lps
Vascular smooth muscle cells
Proliferation
Phenotypic modulation
Signalling pathways
Online Access:https://www.karger.com/Article/FullText/486024

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