Scratching the Surface—An Overview of the Roles of Cell Surface GRP78 in Cancer

Scratching the Surface—An Overview of the Roles of Cell Surface GRP78 in Cancer

The 78 kDa glucose-regulated protein (GRP78) is considered an endoplasmic reticulum (ER)-resident molecular chaperone that plays a crucial role in protein folding homeostasis by regulating the unfolded protein response (UPR) and inducing numerous proapoptotic and autophagic pathways within the eukar...

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Bibliographic Details
Main Authors: Jack Chen, Edward G. Lynn, Tamana R. Yousof, Hitesh Sharma, Melissa E. MacDonald, Jae Hyun Byun, Bobby Shayegan, Richard C. Austin
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Biomedicines
Subjects:
GRP78
cancer
autoantibody
Online Access:https://www.mdpi.com/2227-9059/10/5/1098

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