Choreography of the centrosome
More than a century ago, the centrosome was discovered and described as “the true division organ of the cell”. Electron microscopy revealed that a centrosome is an amorphous structure or pericentriolar protein matrix that surrounds a pair of well-organized centrioles. Today, the importance of the ce...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844020300839 |
| _version_ | 1818962479004254208 |
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| author | Maria Alvarado-Kristensson |
| author_facet | Maria Alvarado-Kristensson |
| author_sort | Maria Alvarado-Kristensson |
| collection | DOAJ |
| description | More than a century ago, the centrosome was discovered and described as “the true division organ of the cell”. Electron microscopy revealed that a centrosome is an amorphous structure or pericentriolar protein matrix that surrounds a pair of well-organized centrioles. Today, the importance of the centrosome as a microtubule-organizing center and coordinator of the mitotic spindle is questioned, because centrioles are absent in up to half of all known eukaryotic species, and various mechanisms for acentrosomal microtubule nucleation have been described. This review recapitulates the known functions of centrosome movements in cellular homeostasis and discusses knowledge gaps in this field. |
| first_indexed | 2024-12-20T12:29:58Z |
| format | Article |
| id | doaj.art-10bc3374f1ad48acbf5bbc229862d195 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-12-20T12:29:58Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-10bc3374f1ad48acbf5bbc229862d1952022-12-21T19:40:45ZengElsevierHeliyon2405-84402020-01-0161e03238Choreography of the centrosomeMaria Alvarado-Kristensson0Molecular Pathology, Department of Translational Medicine, Lund University, Skåne University Hospital, Malmö, SE-20502, SwedenMore than a century ago, the centrosome was discovered and described as “the true division organ of the cell”. Electron microscopy revealed that a centrosome is an amorphous structure or pericentriolar protein matrix that surrounds a pair of well-organized centrioles. Today, the importance of the centrosome as a microtubule-organizing center and coordinator of the mitotic spindle is questioned, because centrioles are absent in up to half of all known eukaryotic species, and various mechanisms for acentrosomal microtubule nucleation have been described. This review recapitulates the known functions of centrosome movements in cellular homeostasis and discusses knowledge gaps in this field.http://www.sciencedirect.com/science/article/pii/S2405844020300839Biological sciencesCell biologyCytoskeletonDevelopmental biologyMembraneMolecular biology |
| spellingShingle | Maria Alvarado-Kristensson Choreography of the centrosome Heliyon Biological sciences Cell biology Cytoskeleton Developmental biology Membrane Molecular biology |
| title | Choreography of the centrosome |
| title_full | Choreography of the centrosome |
| title_fullStr | Choreography of the centrosome |
| title_full_unstemmed | Choreography of the centrosome |
| title_short | Choreography of the centrosome |
| title_sort | choreography of the centrosome |
| topic | Biological sciences Cell biology Cytoskeleton Developmental biology Membrane Molecular biology |
| url | http://www.sciencedirect.com/science/article/pii/S2405844020300839 |
| work_keys_str_mv | AT mariaalvaradokristensson choreographyofthecentrosome |